Kodi njira iyi ya Novel MEND the Alzheimer's Mind?
Kafukufuku wina akuyendetsa njira ya MEND monga njira yothetsera, komanso kusintha, zizindikiro za matenda a Alzheimer's.
Matenda a Alzheimer's is a condition that affects about 5.3 million Americans. Zizindikiro zake zimaphatikizapo kukumbukira kukumbukira, kusokonezeka, kusokonezeka maganizo , ndi kulankhulana. Kuchokera kumalo osasunthika, chiwongolero cha Alzheimers chimathera kuwonongeka kwa ubongo ndi thupi, komanso pomaliza imfa.
Mwamwayi, mankhwala ena atsopano ochizira matenda a Alzheimers ayesedwa kwa zaka khumi zapitazi ndipo pakalipano alephera kupanga kusiyana kwakukulu m'mayesero awo. Ndipotu, Alzheimer's Association imalongosola kuti matenda a Alzheimer ndi amodzi mwa zifukwa khumi zokha zomwe zimayambitsa imfa popanda mankhwala kapena mankhwala ochiritsira. Mankhwala ochepa chabe amavomerezedwa ndi Food and Drug Administration (FDA) kuti athetse matenda a Alzheimers, ndipo mphamvu zawo sizingatheke.
Komabe, mu kafukufuku wofalitsidwa mu June 2016, gulu la ochita kafukufuku lipoti kuti mwina lingasinthe. Phunziroli limalongosola kusintha kwakukulu-kufika poti olembawo adatcha "kusintha" kwa zizindikiro-mwa anthu amene kale anapezeka kuti ali ndi vuto la Alzheimer kapena lodziŵa pang'ono . (Kufooka kwachidziwitso pang'ono ndizochitika pamene kugwa kwa kulingalira ndi kukumbukira kwapezeka.
Zowonjezera chiopsezo chakuti Alzheimers adzakulitsa.) Komanso, ochita kafukufuku adawonetsa kuti kusinthaku kwadzidzidzi kwakhalabe kolimba pamene otsogolera akupitiriza kutsatira njira ya MEND.
Kodi MEND N'chifukwa Chiyani Zingagwire Ntchito?
MEND ndi chidule chomwe chimapangitsa kuti kagwiritsidwe kake kagwiritsidwe ntchito kamene kachulukidwe.
Cholinga cha njira ya MEND ndi kuyang'ana pazinthu zambiri za thanzi la munthu, osati kufunafuna mankhwala ozizwitsa omwe amaloza malo amodzi okha, monga mapuloteni a betyloid omwe amamanga ndi kupanga mapulaneti mu ubongo wa anthu omwe ali ndi Alzheimer's .
Ofufuza a MEND amayerekezera njira zawo ndi zina za matenda aakulu monga khansa, HIV / AIDS, ndi matenda a mtima. Kuchita bwino pamatendawa kumaphatikizapo kukula kwa njira yogulitsa zakudya zomwe zimaphatikizapo mankhwala osakaniza mankhwala omwe amadziwika payekha malinga ndi momwe munthu aliyense alili.
Mofananamo, pamene tiyang'ana zomwe zimayambitsa matenda a Alzheimer , ofufuza ambiri amaganiza kuti n'zosatheka kuti pali chinthu chimodzi chomwe chili ndi udindo. Zowonjezereka, zifukwa zambiri zimathandizira kuti chitukuko cha Alzheimer ndi mitundu ina ya dementia .
Kuphatikiza zifukwa zingapo kumakhala kosavuta komanso pamene tikuyang'ana momwe njira zosiyanasiyana (monga kudya , zolimbitsa thupi , ndi kuganiza zamaganizo ) zasonyeza kuti pali zochepa zomwe zimawathandiza kuthetsa malingaliro . Ngati njira zosiyanazi ziphatikizidwa, ndizotheka kuti njira yochulukirapo yothandizira chilakolako cha Alzheimers idzapindulidwe chifukwa njira iliyonse ingakwaniritse mbali yosiyana siyana ya zomwe zimayambitsa, kapena zimapangitsa kuti chidziwitso chitheke.
Zina mwa madera omwe MEND akuyesa ndi zolinga zikuphatikizapo:
- Mankhwala a homocysteine
- Vitamini B12
- Kugona
- Zakudya
- Magazi a shuga
- Zochita zolimbitsa thupi
- Kudziwa ndi kuchiza matenda obisala
- Kusokonezeka maganizo
Kafukufuku Wophunzira
Ophunzira khumi anali nawo mu phunziroli. Kumayambiriro kwa phunzirolo, aliyense wa iwo anadziŵa kuti ali ndi vuto la Alzheimer's or mildness of mind. Matendawa adayesedwa ndi mayesero osiyanasiyana kuphatikizapo mazira a hippocampal , MRIs , PET scans, test Stroop , homocysteine level, test test span, test test memory , MMSE , mbiri ya kuchepetsa kukumbukira kukumbukira, ndi vuto lofufuza mawu .
Ophunzirawo adayesedwa kuti adziwe ngati anali APOE4 ogulitsa zamoyo. Mafupa a APOE4 amachititsa kuti munthu athe kukhala ndi matenda a Alzheimer, koma sizikuwatsimikiziranso.
Mmodzi mwa anthu khumi omwe anali nawo mu phunziroli anaphatikizidwa mu dongosolo lachidziwitso la mankhwala lomwe limakhudza magawo angapo malinga ndi zotsatira za mayeso. Zina mwazitsogozo zawo zinali kuphatikizapo kuchuluka kwa tulo pa usiku, kutenga melatonin (kuwonjezera masoka ) kuti apange tulo tokha, kupititsa patsogolo zakudya zawo kuti athetse shuga , gluten, nyama ndi mbewu zosavuta, ndi kuwonjezera zipatso, ndiwo zamasamba , blueberries ndi osalima nsomba, kusala musanayambe kugona usiku kwa maola atatu ndi maola 12 pa usiku, mavitamini D3 , C ndi / kapena E, tsiku lililonse mankhwala a citolin , ukhondo wabwino wa mano , mazira a kokonati mafuta ndi curcumin ( tumeric) , mankhwala a mahomoni, kusamalira maganizo monga yoga, kuchita masewero olimbitsa thupi komanso kuganizira nthawi zonse.
Zotsatira
Mmodzi mwa anthu khumi omwe ali nawo mu phunziroli adapeza kusintha kwakukulu mukumvetsetsa kwawo, kuchokera pazopoti zawo komanso za okondedwa awo, komanso zotsatira za kuyesedwa kwa chidziwitso. Maphunzirowa anali oti kumapeto kwa phunziro, ambiri mwa ophunzirawo sanakumane ndi zovuta zowonongeka za kuvutika kwa Alzheimer kapena kuchepa kwa chidziwitso. Kuonjezerapo, ntchito yawo yamaganizo imakhala yosakhazikika kwa zaka zinayi tsopano, yomwe ndi nthawi yaitali kwambiri yomwe imodzi mwa anthu akhalapo pamtandowu. Izi zakhala zikupindulitsa kwambiri makamaka pamene mukukambirana za mankhwala a Alzheimer's.
Zitsanzo zina za kusintha kwakukulu mu phunziroli ndi chiwerengero cha 23 cha Mental State Exam (MMSE) cha 23 (chomwe chingawonetsere matenda ochepa a Alzheimer's) amene amapindula kufika pa 30 (mapiritsi angwiro), mapepala apamwamba a MMSE 22 omwe anakula bwino mpaka 29 , ndi kuchuluka kwakukulu kwa kukula kwa hippocampus mu ubongo wa wina mwa ophunzirawo. Phunziroli linanena kuti buku la hippocampal la munthuyu linayamba pa 17th percentile ndipo linawonjezeka kufika 75 percentile. Izi ndizodziwika chifukwa hippocampus ndi malo mu ubongo omwe nthawi zambiri amagwirizanitsidwa ndi luso lokumbukira chidziwitso, ndipo kukula kwazing'ono kwagwirizanitsidwa ndi kukumbukira kukumbukira.
Pomalizira, asanalowe nawo mu phunziroli, ambiri mwa ophunzirawo anali ndi mavuto kuntchito kapena panyumba zokhudzana ndi ntchito yawo yomvetsetsa. Pamapeto a phunziroli, ambiri adasintha pakutha kwawo kuti azigwira bwino ntchito ndi kunyumba.
Nkhani Yofanana Yofufuza
Mu 2014, kufufuza komweku kunachitika ndi Dale E. Bredesen ndipo adafalitsidwa mu nyuzipepala ya Aging . (Bredesen anali mmodzi wa olemba omwe adafalitsidwa mu 2016.) Phunziro la 2014 linaphatikizansopo anthu 10 omwe ali ndi vuto la Alzheimer's, kuchepa kwa chidziwitso chofatsa kapena kukhumudwa kwaumwini . MEND protocol anagwiritsidwa ntchito kwa aliyense wa anthuwa, ndipo zonse koma zodziwika bwino zodziwika bwino. Munthu wachisanu, munthu yemwe ali ndi matenda ochedwa Alzheimer's disease , adapitiriza kuchepa ngakhale kuti MEND protocol.
Lipoti la phunziroli linazindikira kusintha kwakukulu ndi kofunika pambuyo poti MEND protocol imagwiritsidwa ntchito - kuthekera kugwira bwino ntchito. Ananena kuti anthu asanu ndi mmodzi mwa khumiwo anayenera kusiya ntchito zawo kapena anali ndi mavuto aakulu pantchito yawo chifukwa cha mavuto awo. Pambuyo pochita nawo njira ya MEND, onse asanu ndi mmodzi adatha kubwerera kuntchito kapena adziŵa bwino ntchito yomvetsetsa mu ntchito zawo.
Mapulogalamu
Mwachiwonekere, phunziroli likupambana (ndilo lakale, komanso) poletsa kusintha kwa matenda a Alzheimer kwa anthu omwe ali nawo chidwi ndi zosangalatsa ndipo zingakhale zofunikira kwambiri pakuchita, kuchiritsa, ndi kuteteza matenda a Alzheimer. Kuonjezerapo, lingaliro lopangitsa kuti titha kuphatikiza zosiyana pa zomwe timadziwa kale za umoyo wa ubongo zikuwoneka ngati zomveka, makamaka kuperewera kwa kupambana kwa mayesero ena a chipatala cha mankhwala otheka.
Cons
Ngakhale zotsatira zake zilimbikitsa, pali ena mwasayansi omwe akufunsa kuti phunziroli ndi losavomerezeka komanso losakondera chifukwa si phunziro la kafukufuku wopitilira kawiri konse. Phunziro lachidziwitso lachiwiri ndilo komwe asayansi, kapena ophunzira, sadziwa yemwe akulandira chithandizo. Zimalepheretsa kuti zotsatira za phunzirolo zikhudzidwe ndi zosakhudzidwa za ofufuza, komanso kuti mwina anthu omwe akugwira nawo ntchito amakhudzidwa ndi zotsatira za placebo (kumene akuyembekeza kuti apite patsogolo ndipo potero amachita).
Ena akutsutsa phunziroli chifukwa silinena momwe phunziroli linasankhidwiritsidwira, ndipo kukula kwazitsanzo ndi kochepa kwambiri pa 10 okha. Ndipo, pamene mayesero ofanana amalingaliro akubwerezedwa, pali chizoloŵezi cha mayeso- anthu ogwira ntchito kuti apititse patsogolo ntchito yawo.
Palinso nkhaŵa kuti ochita kafukufuku akufuna kuyang'ana pa zotsatira za phunziro kuyambira pamene MEND protocol ikugulitsidwa ndi kugulitsidwa ndi Muses Labs ngati njira yopereka chithandizo kwa odwala omwe amapereka chithandizo kwa odwala awo.
Ochita kafukufuku omwe akuphatikizidwa mu phunziroli akuchenjezerani kuti malamulowa ndi ovuta komanso ovuta kutsatira. Zoonadi, akufotokozera momwe polojekitiyi ikufotokozera kuti palibe aliyense mwa iwo omwe atsatira ndondomeko yonse ya MEND protocol.
Chotsatira, ndizosangalatsa kuzindikira kuti ambiri mwa ophunzira a maphunziro onsewa anali ocheperapo kusiyana ndi ambiri omwe ali ndi matenda a Alzheimer's komanso mitundu ina ya dementia. Izi zingayambitsenso funso ngati MEND protocol ikhoza kukhala yogwira ntchito kwa anthu omwe ali okalamba, kapena ngati zaka zazing'ono zapadera zathandiza kuti njira ya MEND ipambane.
Kodi Chotsatira N'chiyani?
Ngakhale mafunso awa ndi ndemanga, zotsatira za phunziroli zikulimbikitsa. Amatsindika kufunika koyambiranso njira yathu yothandizira matenda a Alzheimers, komanso amapereka chiyembekezo kumadera omwe zinthu zakhala bwino kwambiri.
Kupitiliza kafukufuku m'dera lino ndi gulu lalikulu la ophunzira kudzera mu mayesero ochiritsidwa ndi chithandizo cha kuchipatala ndichinthu chofunikira kwambiri kuti mudziwe kuti zenizeni zenizeni zokhudzana ndi matenda a Alzheimer ..
Zotsatira:
Kukalamba. 2014 Sep; 6 (9): 707-717. Kusintha kwa kuchepa kwa chidziwitso: Pulogalamu yamakono yochiritsira. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221920/
Kukalamba. 06/12/16. Kusintha kwa kuchepa kwa chidziwitso ku matenda a Alzheimer's. http://www.impactaging.com/papers/v8/n6/full/100981.html#bibl_1
EMBO Molecular Medicine. 2013 Jun; 5 (6): 795-798. Zotsatira zam'badwo wotsatira za matenda a Alzheimer's. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779441/
Zimayambitsa Ma Labs. MEND Protocol.
Science Blogs. June 24, 2016. MEND ™ protocol ya matenda a Alzheimer: Mankhwala ogwira ntchito pa steroids? (kubwereranso) http://scienceblogs.com/insolence/2016/06/24/the-mend-protocol-for-alzheimers-disease-functional-medicine-on-steroids-revisited/