Kugwirizana kwa Nthawi ndi Kugona, Mahomoni, Mahomoni, ndi Metabolism
Masewera a Circadian angakhale chinthu chovuta kwambiri kumvetsetsa mu dziko la mankhwala ogona. Pali mau ambiri osokoneza ndipo zimadalira sayansi yomwe imayandikira mosavuta. Mwamwayi, kumvetsetsa kwakukulu kwa sayansi ya nyimbo za circadian kungapezeke ndipo kungakuthandizeni kufotokoza nthawi zina za kugona , kugona kwa tsiku, ndi mavuto ena ogona.
Kutembenuka kwa Dziko
Nthaŵi ya maola 23 ndi 56 mphindi ya tsiku ndikutembenuka imapereka chidziwitso chodziŵika cha kuwala, kutentha, chakudya, ndi zowonongeka. Kupyolera mu kusintha kwa thupi, thupi lathu limagwiritsidwa ntchito moyenera komanso nthawi zina.
Mu 1959, Franz Halberg anagwiritsira ntchito mawu akuti circadian, ochokera m'Chilatini kutanthauza "pafupifupi tsiku." Limatchula maulendo angapo a maola 24 omwe amapangidwa pafupifupi pafupifupi chilichonse chamoyo padziko lapansi.
Clock Internal
Mu thupi lathu, pali dongosolo lomwe likuyendera nthawi ndipo limagwirizanitsa ndondomeko zamkati mkati mwa zochitika za tsiku ndi tsiku mkati mwa chilengedwe. Zina mwa njira zofunikazi ndizo:
- Kugona ndi kudzuka
- Metabolism
- Kutentha kwa thupi lathunthu
- Cortisol
- Mazinga a Melatonin
- Mahomoni ena (hormone ya kukula, mahomoni a chithokomiro, ndi zina zotere)
Kulamulira kwa njirayi kumapangidwira maonekedwe athu. Makina amavomereza nyimbo zomwe zidzapitilira popanda zochitika kunja.
Geni yoyamba ya mammalian, Clock , inadziwika mu 1994. Zida zambiri zowonjezera zakhala zikudziwika kuti zimakhala ndi maselo akuluakulu omwe amachititsa maselo ena, maselo, ndi thupi.
Selo iliyonse m'thupi lathu imatsatira chitsanzo cha circadian, zomwe zimagwirizana kwambiri ndi zamoyo zomwe zimagwiritsidwa ntchito nthawi zonse malinga ndi zomwe zilipo ndipo zimakhazikitsidwa ndi kagulu kakang'ono ka maselo m'kati mwa ubongo wa hypothalamus .
Kupyolera mu mahomoni ndi zinthu zina zomwe sizinawonongeke, chigwirizano cha pacemaker chimagwirizanitsa mawotchi am'mbali omwe ali m'maselo monga osiyanasiyana monga mtima, chiwindi, ndi mavadipose.
Kuwala kumaonekera ndi maso ndikuyenda kudzera mu retina kupita ku mitsempha ya optic. Pamwamba pa optic chiasm, kumene mitsempha iwiri imayambuka m'maso, imakhala pamutu wapamwamba (SCN). Ili ndilo ola labwino la thupi. Amagwiritsa ntchito njira zambiri za thupi zomwe zimafotokozedwa nthawi yomwe kuwala ndi mdima zimakhalapo.
Zitsanzozi zidzapitirizabe popanda kunja kwa nthawi, koma zikhoza kusiyana pang'ono ndi kutalika kwa tsiku la geological. Zotsatira zake, pokhapokha pokhapokha mutha kukhazikitsanso zizindikiro, nthawi yotsatilayi ingapangitse kukhala ochepa. Kuchuluka kwa kusintha kosadalira kumadalira ma genetic, kapena tau, ndi anthu ambiri omwe ali ndi mawotchi apakati omwe amatha maola oposa 24.
Zimamveka kuti ma genetic ndi momwe timagwirizanirana ndi zinthu zina zachilengedwe-makamaka kuwonetsera kuwala kwa dzuwa- zimakhala ndi zotsatira zofunikira pakubwezeretsa nthawi yamkati. Zisonkhezero zakunja izi zimatchedwa zeitgebers , kuchokera ku German chifukwa cha "wopereka nthawi".
Kuchokera ku Sync
Pamene ola la mkati limasokonekera kumalo athu kapena maudindo athu, ziwalo zobisika monga kuchedwa ndi syndromes zapamwamba zogonana zimatha kuchitika.
Ndi kuchotsa kwathunthu kuchokera ku kuzindikira kwa kuwala, monga kumapezeka mu khungu lathunthu, Thupi Lopanda 24 limapezeka.
Mavuto amenewa nthawi zambiri amagwirizanitsa ndi kusowa tulo komanso kugona kwa tsiku ndi tsiku komanso kusagwirizana komwe kumachitika chifukwa cha kugonana komwe kumachititsa kuti anthu asamagwire ntchito. Mwamwayi, chithandizo cha matenda a circadian chingakhale chothandiza kwambiri ndipo dokotala wokhala ndi ubwino wogona akhoza kupereka malangizo othandiza ndi zothandiza.
> Zotsatira:
> Lewy, AJ ndi al . "Kuthamanga kwasintha nthawi ya munthu pogwiritsa ntchito melatonin." Restre Behav Ubongo . 1996; 73: 131-134.
> Peters, BR. "Nthaŵi Yogona Yopanda Nkhazikika ndi Kugalamuka." Kuunika kwa Mavuto a Kugona. Mchipatala Chogona . 9 (2014) 481-489.
> Piggins, HD. "Mankhwala a mawonekedwe a anthu." Ann Med . 2002; 34 (5) 394-400.
> Reid, KJ ndi Zee, PC. "Zovuta za Circadian za kugona tulo," mu Mfundo ndi Zochita za Sleep Medicine . Kusinthidwa ndi Kryger MH, Roth T, Dement WC. St. Louis, Missouri, Elsevier Saunders, 2011, tsamba 470-482.
> Sack, RL ndi Lewy, AJ. "Circadian rhythm matenda ogona: maphunziro kuchokera kwa akhungu." Kugonjera Mankhwala Openda . 2001; 5 (3): 189-206.