Beta Amyloid Mapuloteni, Plaque, ndi Alzheimer's

Mapuloteni a Beta-amyloid ndi plaque - awa ndi awiri omwe akugwirizana ndi ubongo amasintha mu matenda a Alzheimer's. Mukufuna kudziwa zambiri? Nazi mfundo 9 kwa inu:

1. Mapuloteni otchedwa beta-amyloid m'bongo amaonedwa kuti ndi chimodzi mwa zizindikiro za matenda a Alzheimer's . (Chizindikiritso china chachikulu ndi mitsempha ya ubongo .) Mapuloteniwa amatha kupanga palimodzi (osakhoza kusungunuka) m'mapopu kunja kwa neurons.

1. Mapuloteni a beta-amyloid amamanganso pa synapses ndipo amalepheretsa kulankhulana kuchokera ku selo kupita ku wina mu ubongo.
2. Musanayambe gulu la beta-amyloid ndi lalikulu kwambiri kuti litchulidwe , mapuloteniwa amayamba kupanga oligomers . Oligomers adakali osungunuka (atha kusungunuka), magulu ang'onoang'ono a beta-amyloid.
3. Ngakhale kuti zizindikiro zakhala zikudziwika kuti ndi chimodzi mwa zifukwa zomwe zimayambitsa Alzheimer's, ofufuza aposachedwapa adayankha funsoli, pozindikira oligomers omwe atchulidwa pamwambapa mwina kukhala mmodzi wa zifukwa zazikulu popewera kulankhulana kuchokera ku selo kupita ku selo. Chifukwa chimodzi cha izi ndi chakuti anthu ena ali ndi zida zapamwamba mu ubongo, koma alibe zizindikiro za matenda a Alzheimer's .
4. Kuwonjezera apo, kafukufuku wina wasonyeza kuti kusintha kwa chidziwitso kumayambira kumayambiriro kwa mapuloteni a beta-amyloid kuchokera ku zikuluzikulu za chipika.
5. Sayansi inapeza mapuloteni a beta-amyloid zaka zoposa 100 zapitazo. Iwo anali oyamba kudziwika ndi Dr. Alois Alzheimer mu 1906.

1. Beta-amyloid ndi mbali ya mapuloteni akuluakulu otchedwa amyloid precursor protein .
2. Ndemanga yosangalatsa: "Asayansi ambiri amaganiza kuti ma plaques kwenikweni angayesedwe mofulumira kwambiri ndi ubongo kuti awononge mankhwalawa kuti asakhalenso ndi neuroni" (Alzheimer's Disease Education and Referral Center).
3. Kafukufuku wopangidwa ku bungwe la UC Davis Alzheimer's Disease Center anapeza kuti chitetezo cha mthupi chinayambanso chimodzimodzi ku pulasitiki monga momwe zinkachitira mabakiteriya, zomwe zimayambitsa kutupa mu ubongo umene unawonongeka ndi neurons. Kutupa m'mimba kumagwirizanitsa ndi matenda a Alzheimer.

Zotsatira:

_{Alzheimer's Association. Mankhwala Osokoneza Bongo a Alzheimer Targeting Beta-Amyloid ndi "Amyloid Hypothesis." 2008.}

_{Alzheimer's Association. Zambiri Za Makapu.}

_{DANA Foundation. Oligomers a Amyloid-Beta Angagwirizanitse ndi Dementia ya Alzheimer. July 12, 2010.}

_{National Institute of Aging. Matenda a Alzheimer Education and Referral Center. January 22, 2015.}

_{Stanford Medicine. Asayansi Akuvumbula Momwe Beta-amyloid Angayambitsire Alzheimer's. September 2013.}

_{UC Davis Health System. Mankhwala a Allosser omwe amachititsa Amyloid ndi Bacteria Trigger Same Immune Response.}