Akatswiri ena amakhulupirira kuti chipangizo cha amyloid chimasokoneza bwino kwambiri chimene chimayambitsa matenda a Alzheimer's .
Ngakhale mafunso ambiri asanayankhidwe, amyloid amachititsa kuti chiwerengero cha peptide chotchedwa amyloid-beta chikhale chofunika kwambiri, ndicho chofunika kwambiri mu matenda a Alzheimer's: Kukumana kumeneku kumapanga zochitika zambiri zomwe zimachititsa imfa ya maselo a ubongo, ndipo potsiriza, Matenda a Alzheimer.
Momwe Amyloid-Beta Amayambitsa Alzheimer's
Amyloid-beta imapangidwa kuchokera ku puloteni yaikulu yotchedwa amyloid precursor protein (APP). Ochita kafukufuku samadziwa bwino ntchito ya APP, komabe zingakhudze ntchito za maselo a ubongo. Mapuloteni apadera (otchedwa secretase) adula mapuloteniwa pa malo enaake, ndipo chimodzi mwa zinthu zomwe zimagwiritsidwa ntchito pa "cleavage" iyi ndi peyde ya amyloid-beta. Ma peptide amyloid-beta amaphatikizana pamodzi ndi omwe amachitcha oligomers, ndipo malinga ndi momwe amyloid amavutitsira maganizo, ndi oligomers awa omwe ali poizoni ku maselo a ubongo, zomwe zimayambitsa mavuto oyambirira a chidziwitso ku matenda a Alzheimer. Pambuyo pake, oligomerswa amapanga mabala omwe ali ndi matenda a Alzheimer's, koma ndi oligomers - mosiyana ndi zipika - zomwe ndizo zowononga.
Ngakhale maumboni angapo omwe amathandiza amyloid amachititsa mantha, palinso mavuto angapo kwa iwo.
Chifukwa chimodzi, amyloid-beta yomwe imakhala m'matumba amapezeka ku ukalamba wabwino komanso matenda a Alzheimer's. Pachilombo china, mapuloteni ena amatchedwa tau mawonekedwe omwe amagwirizanitsa bwino ndi mavuto a chidziwitso ku matenda a Alzheimer than the plaques. Pomalizira, palinso ziphunzitso zina, monga mitochondrial cascade hypothesis, zomwe zafotokozedwa monga kufotokoza zomwe zimayambitsa matenda a Alzheimer's.
Chitsime:
Christensen DD. Matenda a Alzheimer: Kupititsa patsogolo chitukuko cha mankhwala osokoneza bongo. CNS Wopenya. 2007; 12: 113-123.
-Nkhani Yosindikizidwa ndi Esther Heerema, MSW