Kodi Mankhwala Ochepetsa Matenda a Antibiotic Amathandiza Odwala Matenda a Chifuwa?
Mbiri ya Kusaka kwa Chifukwa ndi Chithandizo
Ndi mankhwala osadziwika a mitundu yoposa 100 ya nyamakazi , kuchiza ndi kulimbana ndi zizindikiro zopweteka ndizo zikuluzikulu za odwala ndi madokotala. M'zaka za m'ma 1930, chifukwa cha mabakiteriya chifukwa cha matenda a nyamakazi anafufuzidwa, koma kafukufukuyo anali wamphindi pokhapokha pazifukwa zosiyana za matenda opatsirana odwala matendawa .
Mu 1939, chitsogozo choyamba chenicheni chokhudzana ndi matenda opatsirana a nyamakazi chinayambira pamene mycoplasma, mabakiteriya omwe ali ndi tizilombo toyambitsa tizilombo, adatengedwa ndi odwala omwe ali ndi kachilombo koyambitsa matendawa. Ofufuza anali atasonyeza kale kuti mycoplasma imayambitsa nyamakazi mu mbewa, makoswe, nkhuku, mbuzi, ndi ng'ombe. Iwo anali atapeza mapepala a mycoplasma mu timapepala tautundu wa anthu, makamaka akazi.
Mu 1949 ku International Congress pa Rheumatic Diseases, ubalewu ukhoza kuyanjana pakati pa mycoplasmas ndi matenda olowa nawo. Atalandira imodzi mwa ndalama zoyamba za kafukufuku wa National Institutes of Health (NIH) mu 1950, Thomas McPherson Brown, MD ndi anzake pa kafukufuku wamagulu a nyamakazi adanena chaka chotsatira kuti njira yodwala matenda a matenda odwala matenda a nthendayi inali yowonongeka kwambiri ndi antigen ndi antibody ( ndi mycoplasma monga antigen akuganiza) osati mtundu wopatsirana ndi wopatsirana.
Mu 1955, bungwe lochita kafukufuku linanena kuti mabanga anga, mosiyana ndi mabakiteriya ndi mavairasi angakhale m'miyambo yambiri ya maselo popanda kuwononga maselo a minofu. Pofuna kuthandizira macoplasma ngati causative agent / antigen, mu 1964 chiwerengero chokwanira cha majeremusi a mycoplasma m'magazi a odwala nyamakazi ndi a lupus anapezeka, akuwonetsa matenda omwe alipo tsopano kapena oyamba.
Komanso anadziwika kuti ndi 4: 1 chiwerengero chokwanira cha majeremusi a mycoplasma azimayi omwe amasonyeza kuti mgwirizano ndi zochitika zapamwamba za nyamakazi ya nyamakazi muzimayi.
Thandizo la antibiotic
Kuyesera kusonyeza mphamvu ya mankhwala a tetracycline kunayambika ndipo koyamba kunanenedwa zaka zoposa 40 zapitazo ndi Thomas McPherson Brown, MD. Patadutsa milungu iwiri pambuyo pa imfa ya Brown mu 1989, NIH anapempha kuti apereke thandizo la mankhwala a tetracycline chifukwa cha matenda a nyamakazi omwe anali kufunafuna. Zotsatira zoyambirira za mayesero a zachipatala, omwe tsopano amadziwika kuti MIRA kapena Minocycline mu Rhumumida ya Arthritis, adalonjeza ndipo a NIH anapempha thandizo la maphunziro a mycoplasma ndi othandizira ena monga zifukwa za matenda a chifuwa chachikulu mu 1993, komanso kufufuza kwa ma antibayotiki amkati Matenda a nyamakazi mu 1994.
Zotsatira za mayeso a chipatala cha MIRA, adati, "Odwala omwe akudwala RA wofatsa mpaka pano amakhala ndi chithandizo chamankhwala ena. Sikuti mankhwala okhawo amachepetsa kwambiri zizindikiro, koma zotsatira zake zinali zochepa komanso zochepa kuposa zomwe zimawonedwa ndi ena ambiri mankhwala opatsirana. "
"N'chifukwa Chiyani Arthritis?"
Kwa zaka zambiri, maganizo omwe amagwiritsa ntchito mycoplasma monga opatsirana opatsirana ndi tetracycline monga mankhwala opangira ma antibiotic asokonezedwa ndi kusowa ndalama zokwanira pofuna kufufuza zambiri ndi ndale.
"N'chifukwa Chiyani Arthritis?" ndi Harold W. Clark, Ph.D., mmodzi mwa anzake a Brown, akuyesa matenda a chifuwa chachikulu, zaka zambiri za kafufuzidwe, kufunafuna chithandizo, ndi kukhumudwa kwa ochita kafukufuku amene vuto lawo la anti-mycoplasma chithandizo linanyalanyazidwa kwa zaka 40 ndi boma ndi mabungwe osiyanasiyana a nyamakazi. Clark akukhulupirira kuti ntchitoyi inalepheretsedwa chifukwa chithandizo chosavuta, chosavuta chimaopseza chithandizo chachipatala kuyambira pamene odwala angafunike kuchipatala pang'ono.
Madokotala ambiri amakhalabe osakayikira ndipo samapereka chithandizo cha mankhwala ochizira ma ARV kwa odwala awo. Arthritis Foundation inkawoneka ngati yosagwedezeka ngakhale pambuyo poti mankhwala opatsirana pogonana ankaonedwa ngati otetezeka ndi ogwira mtima.
Akuluakulu a zachipatala akuti mazikowa sakuwona kuti mankhwalawa akuyenda bwino komanso amaphunzira kwambiri mlingo komanso kugwiritsa ntchito minocycline nthawi yaitali.
Malingana ndi American College of Rheumatology, "Minocycline imaperekedwa kwa odwala omwe ali ndi zizindikiro za nyamakazi yochepa kwambiri. Nthawi zina zimagwirizanitsidwa ndi mankhwala ena kuti athe kuchiza odwala ndi zizindikiro zolimba za nyamakazi imeneyi."
Zotsatira:
N'chifukwa Chiyani Arthritis? Kufufuza Cholinga ndi Chithandizo cha Matenda a Matenda a Khunyu, ndi Harold W. Clark, Ph.D., 1997
Cannon, Michael. Minocycline (Minocin). American College of Rheumatology. Kusinthidwa kwa March 2015.