Sizoloŵera Ndi Zokwiya
Mipata yaing'ono imayendetsa zidutswa zapadera zomwe zimawathandiza kwambiri mu hemostasis (njira yothetsera magazi pambuyo povulala). Alibe phokoso koma ali ndi puloteni ndi mapuloteni ofunika kwambiri kuti apangidwe. Mipateti imapangidwa ndi megakaryocytes mu fupa.
Mipata ya pulasitiki nthawi zambiri imakhala ndi nyamakazi ya nyamakazi .
Mkhalidwe wa mapaleti okwezeka amadziwika kuti thrombocytosis.
Mu nyamakazi ya nyamakazi, mamembala ndiwo malo owonongera. Kumeneku ndiko kutupa kwanuko komwe kumapezeka, kuphatikizapo maselo a magazi omwe amawaphatikizapo neutrophils ndi macrophages. Maselo amenewo amachititsanso kuti apange mapuloteni a magazi, omwe amachititsa kuti azigwira nawo ntchito yotupa m'thupi.
Mipata ya Dymatitis
Anthu wathanzi ali ndi chiwerengero cha mapiritsi 150,000-400,000 / mm3. Kalekale monga 1972, adatchulidwa m'mabuku a zachipatala omwe ofufuza adapeza chiwerengero cha mapiritsi okwera pafupifupi pafupifupi theka la odwala nyamakazi.
Izi zinapezeka kuti zogwirizana ndi matenda. Ofufuza apeza kuti mgwirizano pakati pa chiwerengero cha mapiritsi okwera ndi anemia , leukocytosis (kuchuluka kwa maselo oyera a magazi), ndi chifuwa chachikulu .
Pali mgwirizano pakati pa hemoglobini ndi chiwerengero cha mapiritsi, kutanthawuza, pamene hemoglobin ili yochepa, chiwerengero cha platelet ndi chokwanira. Kusonkhana kwa sideropenia (kusowa kwachitsulo) ndi kuwerengera kwa mapiritsi sikunali kofunikira.
Anthu ena omwe ali ndi nyamakazi yaikulu ya nyamakazi angakhale ndi chiwerengero choposa mamiliyoni.
Pamene matendawa amaletsedwa ndi mankhwala, chiwerengero cha platelet chimabwereranso kuchibadwa.
Mipata yapamwamba imakwezedwa osati nyamakazi yokhala ndi nyamakazi, komanso m'matenda ena ofooketsa. Kugwirizana kwakukulu kunapezeka pakati pa mapaleti okwera ndi masititis . Zowonjezera zowonjezereka za nyamakazi ya nyamakazi (mwachitsanzo, kukhudza ziwalo za thupi kupitirira malipiro okha) zinapezeka kawirikawiri pakati pa anthu omwe anakweza chiwerengero cha mapiritsi.
Zimayambitsa
Kufotokozera bwino kwa mapepala apamwamba kwambiri kumatenda a nyamakazi amaoneka kuti ndi ofanana ndi matenda a magazi osapitirira nthawi, omwe amadziwika ndi matenda a nyamakazi. Malingana ndi Annals wa Rheumatic Diseases , homeletasis ya platelet imayendetsedwa ndi thrombopoietin.
Thrombopoietin ndidongosolo lalikulu la kukula kwa megakaryocyte ndi kusiyana. Zimagwiriridwa kuti thrombopoietin imatha kugwirizana ndi mankhwala a erythropoietin (hormone yomwe imakhudzana ndi maselo ofiira a magazi) makamaka chifukwa chakuti odwala ambiri omwe ali ndi kachilombo koyambitsa matenda amagazi (red blood cells) ndi owonjezeka a maselo ofiira a magazi. Ngati nthenda ya erythropoietin ikuwonjezeka kwa anthu omwe ali ndi vuto la kuchepa kwa magazi ndi nyamakazi, chiwerengero cha mapiritsi chokwera chikhoza kuchitika.
Chinthu chinanso chikhoza kukhala ngati kuwonjezeka kwaplatelet kunayambika chifukwa cha kuwonongeka kwa mbale kapena kumwa. Ochita kafukufuku ananenanso kuti kuchuluka kwa mapulogalamu angaphatikizepo ndi mayendedwe a immunological mu nyamakazi ya nyamakazi-mwinanso chifukwa cha tizilombo ting'onoting'ono tomwe timakhala ndi synovium .
Malinga ndi Kelley's Textbook of Rheumatology , pali zifukwa zitatu zazikulu za mbale yapamwamba yowerengeka ya matenda a rheumatic:
- Chitetezo cha thrombocytosis, chachiwiri kwa matenda aakulu otupa. Zikatero, maselo a cytokines (IL-1, IL-6, ndi TNF) akhoza kukhala omvera omwe amagwira ntchito mwakhama pa kayendedwe ka kapangidwe ka pulasitiki panthawi yotupa.
- Matenda a mtundu wa thrombocytosis amatha kupezeka chifukwa cha jenjeni ya genetic mutation.
- Clonal thrombocytosis (choyamba kapena chofunika kwambiri) chimakhala chosawerengeka chosasinthika cha kupanga mapeyala chifukwa cha kuchuluka kwa mavitamini.
> Zotsatira:
> Hutchinson RM et al. Thrombocytosis mu nyamakazi ya nyamakazi . Annals wa Rheumatic Diseases. (1976) 35: 138
> Kiraz S. et al. Matenda a m'magazi mumatenda a nyamakazi ndi thrombocytosis, Clinical Rheumatology. 2002 Nov; 21 (6): 453-6.
> Kelley's Textbook of Rheumatology. Kusindikiza Kwachisanu ndi Chinayi. Mutu 17. Platelets ndi Rheumatic Diseases. Masamba 249-251.
> Thrombocytes mu chifuwa chachikulu cha nyamakazi. Scandinavia Journal of Rheumatology. Selroos, O. 1972 1: 136.