The synovium, yomwe imatchedwanso synovial membrane, ndi minofu yofewa yomwe imayendera mipata ya ziwalo zowonongeka, tchire, ndi bursae. Synovium imayendetsa mkati lonse la mgwirizano, pokhapokha ngati chophatikizidwacho chili ndi cartilage . The synovium ili ndi wosanjikiza (malingaliro) ndikukhala mkati (intima). Maselo a mumtima amatchedwa synoviocytes.
Pali mitundu iwiri ya synoviocytes, mtundu A (macrophage-yotengedwa) ndi mtundu B (fibroblast-derived). Chidziwitsochi chimakhala ndi zitsulo zamkati, monga mitsempha ya mitsempha ndi zitsulo zam'mimba, ndi mitsempha. Pansi pazitsulo za synoviocytes, pamakhala minofu ya adipose kapena minofu ya fibrous. The synovium ndi kumene synovial madzi amapangidwa, chinthu chimene chimapatsa komanso chimadyetsa mafupa ndi mafupa mkati mwa capsule wothandizira.
The Synovium mu Chifuwa cha Matenda a Nyamakazi
Mofanana ndi matenda ena ambiri a rheumatic, nyamakazi ya nyamakazi ndi matenda okhaokha . Mu matenda kapena maimidwe a munthu, chitetezo cha mthupi cha munthu, chomwe chimathandiza kuteteza thupi ku matenda ndi matenda, zimayambitsa zida zawo zomangira zifukwa zosadziwika. Mu nyamakazi ya nyamakazi, maselo a chitetezo cha mthupi amapita ku synovium ndi kuyamba kutupa (synovitis). Njira yotupa ikudziwika ndi kuwonjezeka kwa maselo a synovial, kuwonjezeka kwa vascularization, ndi kulowa kwa maselo ndi maselo opuwala, kuphatikizapo ma lymphocytes, maselo a plasma, ndi macrophages opangidwa.
Izi zimawonekera ngati zizindikiro za nyamakazi ya nyamakazi - kutentha , kufiira, kutupa, ndi ululu.
Pamene nyamakazi imayamba kukula, synovium yotentha imalowa ndi kuwononga khunyu ndi fupa la mgwirizano. Minofu yozungulira, mitsempha, ndi ma tendon omwe amathandiza ndi kukhazikika pamodzi amakhala ofooka ndipo sangathe kugwira ntchito bwinobwino.
Zotsatirazi zimapangitsa kupweteka kwa mgwirizano ndi kuwonongeka kwa mgwirizano komwe kumawoneka mwa anthu omwe ali ndi nyamakazi. Kumvetsetsa zomwe zimachitika ku synovium mu nyamakazi ya nyamakazi kumakuthandizani kumvetsetsa zizindikiro ndi matenda aakulu.
Kuchiza kwa Target Inflamed Synovium - Kodi Ikubwera?
Pakhala chidwi pakati pa ofufuza okhudzana ndi chitukuko cha mankhwala ochizira matenda a nyamakazi. Mwachidziwitso, mankhwala osokoneza bongo angapangitse synovium kuti ikhale yowonjezera bwino pamene akuchepetsedwa ndi poizoni. Ngati izi zikanatheka, zoganiza zongopeka zimatha kuperekedwa ku synovium, zomwe zimapereka kuunika kwa synovitis yogwira ntchito m'magulu angapo. Ngakhale kuti pakhala paliponse m'dera lino, phwando lina la synovial siliyenera kupezeka.
> Zotsatira:
> Freemont, Anthony J. The Pathophysiology ya Cartilage ndi Synovium. British Journal ya Rheumatology. 1996; 35 (supp 3): 10-13.
> Garrood T. ndi Pitzalis C. Kuwotchedwa Inflamed Synovium. Kufunafuna Zenizeni. Arthritis ndi Rheumatism. April 2006.
> Kelley's Textbook of Rheumatology. Kusindikiza kwachisanu ndi chinayi. Firestein et al. Biology ya Joint Joint. Masamba 8-10.
> O'Connell, John X., MB FRCPC. Matenda a Synovium. American Journal of Clinical Pathology.
Smith, Malcolm D. Wachibadwa Synovium. Open Rheumatology Journal. 2011; 5: 100-106.