Zotsatira za mtima zimasiyana pakati pa Celebrex, Vioxx, ndi NSAID zoposa.
Nkhaniyi ndi gawo la Archives Arthritis.
Cholemba cha Mkonzi: Pa 09/30/2004, Merck yemwe amapanga Vioxx, adakumbukira padziko lonse, akuletsa malonda a mankhwala. Pa 04/07/2005, Pambuyo pofufuza kalasi ya mankhwala a nyamakazi omwe amadziwika kuti NSAIDs ndi COX-2 inhibitors, a FDA adalengeza zoyenera kuchita.
Dateline: May 29, 2004
Kafukufuku wa ku Canada Akuwonetsa Celebrex Akhoza Kuwonetsa Mankhwala Osokoneza Bongo Kwa Anthu Akale
Anthu omwe ali ndi zizindikiro za nyamakazi nthawi zambiri amapatsidwa mankhwala osokoneza bongo omwe sali osankhidwa (anti-inflammatory anti-inflammatory drugs (NSAIDs) kapena gulu limodzi la atsopano la NSAIDS lotchedwa cyclo-oxygenase-2 inhibitors ( COX-2 selective inhibitors ).
NSAIDs zosasankhidwa zakhala zikugwirizanitsa ndi chiopsezo chowonjezeka cha kusweka mtima kwa mtima. Zochepa zochepa zimadziwika kapena zatsimikizika za zotsatira za mtima za COX-2 selective inhibitors.
Lancet (2004; 363: 1751-56) yasonyeza zotsatira za kafukufuku wa ku Canada okhudza anthu oposa 130,000. Muhammadi Mamdani wochokera ku Institute for Clinical Evaluative Sciences, Toronto, Canada, ndi ogwira nawo ntchito adayesa kufufuza mozama za chiopsezo cha chilolezo cha chipatala cha mtima wosayenerera kuzungulira:
- Anthu 14,500 amagwiritsa ntchito COX-2 inhibitor Vioxx (rofecoxib)
- Anthu okwana 19,000 akugwiritsa ntchito COX-2 inhibitor Celebrex (celecoxib)
- Anthu 5,400 akugwiritsa ntchito NSAID zosasankha
- Anthu 100,000 osagwiritsa ntchito NSAID anali gulu lolamulira
Zotsatira Zophunzira
Poyerekeza ndi gulu lolamulira la osagwiritsa ntchito NSAID, zotsatira zake zinali:
- Anthu ogwiritsira ntchito Vioxx anali ndi chiopsezo chowonjezereka cha 80% cha chilolezo cha chipatala chifukwa cha kusweka mtima kwa mtima.
- Anthu ogwiritsira ntchito NSAID omwe sanali osankha anali ndi 40% oopsa kwambiri ovomerezeka chifukwa cholephera kubereka mtima.
- Anthu ogwiritsira ntchito Celebrex anali ndi chiwerengero chomwecho chovomerezeka m'chipatala chifukwa cholephera mtima monga anthu omwe sanagwiritsepo ntchito NSAIDs.
Kusiyanitsa pakati pa osasankha NSAIDS ndi omwe ali ndi COX-2 ziwalo zovomerezeka pokhapokha ngati aloledwa kukanika kwa mtima kusaganizire kuti akufunikira kuyesedwa kwakukulu, kosayesedwa, kuyesedwa.
Zothandizira zokhudzana
- Celebrex (Celecoxib)
- Vioxx (Rofecoxib)
- COX-2 Selective Inhibitors
- Zambiri Zokhudza NSAIDs
- Mankhwala a Arthritis
Chitsime: COX-2 Inhibitor Yikhoza Kukhala Yowononga Mankhwala Osakaniza Anthu Okalamba, Lancet Issue 29 May 2004
Choyamba chofalitsidwa: 05/29/2004