Viscosupplement for Knee Osteoarthritis
Monovisc ndi jekeseni imodzi yomwe imagwiritsidwa ntchito pochizira ziwalo zamagulu zomwe zimakhudza osteoarthritis . Ndi jekeseni wa intra-articular , kutanthauza, iyo imayikidwa muzowonongeka. Monovisc inakhazikitsidwa ndi Anika Therapeutics, Inc. ndipo idalandira chivomerezo cha malonda kuchokera ku US FDA pa February 25, 2014. Monovisc imagulitsidwa ndi DePuy Synthes, Mitek Sports Medicine pansi pa mgwirizano wa licens ndi Anika.
The hyaluronan (shuga yovuta ya banja la glycosaminoglycan) mu Monovisc ndipamwamba kwambiri maselo olemera, omwe amachokera ku chilengedwe cha hyaluronan. Hyaluronan imachokera ku maselo a bakiteriya ndipo imagwirizanitsidwa ndi njira yothetsera. Monovisc imapereka mlingo wofanana ndi Orthovisc , wina wa Anika Therapeutics viscosupplement - koma Orthovisc imayendetsedwa mu katatu katemera kusiyana ndi jekeseni umodzi.
Zisonyezo
Monovisc imasonyezedwa pofuna kuchiza mafupa a m'magazi kwa odwala omwe alephera kulandira chithandizo chamankhwala, monga mankhwala osagwiritsa ntchito mankhwala komanso mankhwala osokoneza bongo (monga acetaminophen ). Chofunika kwambiri cha mafupa a m'magazi ndi kuwonongeka kwa kagawoti komwe kumayambitsa kupweteka kochulukira komanso kuyenda kochepa mu mgwirizano wokhudzidwa. M'magulu a osteoarthritis, pali zosawonongeka ndi synovial madzi . Synovial madzi amachititsa kuti mgwirizanowu ukhale wovomerezeka.
Mankhwala osokoneza bongo, monga Monovisc ndi ena omwe anavomerezedweratu, amabwereranso mavitamini, omwe amawotcherera.
Zotsatira Zophunzira
Dongosolo lachitetezo komanso logwira ntchito kuchokera ku chipatala chodziŵika bwino, chodziwika bwino, chophatikizirapo chophatikizapo 369 ophunzira omwe ali ndi mafupa a m'magazi ku malo 31 ku US ndi Canada ndiwo maziko a chipani cha FDA cha Monovisc, malinga ndi Anika Therapeutics.
Ophunzirawo anapatsidwa monovisc kapena jekeseni ya saline (mphamvu). Iwo adayesedwa kuti ayambe kupweteka kwambiri pogwiritsa ntchito WOMAC (Western Ontario ndi McMaster Universities Osteoarthritis Index), makamaka kuyang'ana odwala Monovisc omwe adakula bwino mu chiwerengero chawo cha WOMAC poyerekeza ndi odwala pa nthawi ya masabata 12. Gawo lotetezeka lafukufukuli lawonetsera "kuchepa kwa zinthu zovuta" ndipo palibe zovuta zowonongeka ndi Monovisc.
Zina Zogulitsa Mavitamini
Choyamba ma viscosupplement adavomerezedwa mu 1997. Panopa pali mitundu 5 yowonjezera mavitamini, zomwe zambiri zimafuna jekeseni m'malo mwa jekeseni imodzi.
- Hyalgan
- Synvisc ndi Synvisc-One (jekeseni imodzi yopangidwa ndi nkhuku)
- Supartz
- Orthovisc
- Euflexxa
Mphamvu ya Viscosupplementation
Mu 2012, lipoti lofalitsidwa mu Annals la Internal Medicine linanena kuti viscosupplementation inali yopanda ntchito ndi yoopsa. Lipotilo linanena kuti viscosupplementation imapangitsa kuchepetsa kupweteka kwapweteka pamene kungachititse kuti pakhale ngozi yowonongeka ndi zovuta. Izi zinkamveka polemba mndandanda wa mayesero 89 omwe amachititsa odwala odwala osteoarthritis oposa 12,000.
Koma a American Academy of Orthopedic Surgeons amanena kuti "Viscosupplementation ingakhale yothandiza kwa anthu omwe nyamakazi yawo siinavomereze kuchipatala. Zimakhala zogwira mtima ngati nyamakazi imakhala yoyamba (yofatsa mpaka yochepa). pa malo opangira jekeseni, ndipo nthawi zina majekeseni amachititsa kuti kutupa kuwonjezereke. Zitha kutenga masabata angapo kuti ziwoneke bwino pakapita kanthawi pambuyo pa majekeseni. Osati odwala onse adzakhala ndi mpumulo wa ululu Ngati jekeseni ali ndi mphamvu akhoza kubwerezedwa pakapita nthawi, kawirikawiri miyezi 6. Kukhalitsa kwanthawi yaitali kwa viscosupplementation sikudziwikabe ndipo kafukufuku akupitirizabe m'dera lino. "
> Zotsatira:
> FDA imavomereza monovisc, Chithandizo Chatsopano Chokha Chokha Chakumachiritsira Chisoni Chifukwa cha Osteoarthritis ya Knee. Anika Therapeutics. February 25, 2014.
Viscosupplementation kwa Osteoarthritis ya Knee: Kusanthula Kwambiri ndi Kusanthula Meta. August 7, 2012. Rutjes et al. Annals of Internal Medicine.
> Viscosupplementation Kuchiza kwa Arthritis. OrthoInfo. AAOS. April 2013.