Mankhwala oletsa COX sangakhale chinthu chabwino
Kupweteka ndi kutupa, kudandaula kwakukulu kwa anthu ambiri pa nthawi ina pamoyo wawo komanso zochitika tsiku ndi tsiku kwa anthu ambiri okhala ndi nyamakazi, makamaka chifukwa cha cyclooxygenase, kapena COX, mwachidule.
COX ndi puloteni yomwe imapanga prostanoids- prostaglandins , prostacyclins, ndi thromboxanes-zomwe ziri zonse zomwe zimayambitsa kupweteka kotuluka.
Zikuoneka kuti COX siyonse yoipa, ndiyeneranso kuti machitidwe apakompyuta azikhala abwino.
Mankhwala ogwiritsidwa ntchito poletsa COX kuti athetse kutupa, amawoneka ngati malingaliro abwino, koma poletsa COX, pali vuto.
COX-1 Ndi COX-2
M'zaka za m'ma 1990, adapezeka kuti pali mitundu iwiri ya ma cozy-COX-1 ndi COX-2. Zachiwirizi ndi zofunika kwambiri paziwirizi. COX-1 imadziwika kukhalapo m'matenda ambiri. M'matumbo a m'mimba, COX-1 imakhala yodzala m'mimba ndipo imateteza mimba m'mimba yam'mimba. Enzyme ikuphatikizanso mu impso ndi puloletti. COX-2 imapezeka makamaka pa malo otupa.
Zonse COX-1 ndi COX-2 zingayambitse kupweteka ndi kutupa, koma popeza COX-1 ndi mankhwala opindulitsa kwambiri, kugwiritsa ntchito mankhwala osokoneza bongo sikungakhale bwino.
NSAID imaletsa COX
Mankhwala otsutsana ndi kutupa (nonsteroidal anti-inflammatory drugs (NSAIDs), omwe amauzidwa kuti azichiritsa nyamakazi, amagwira ntchito poletsa prostaglandin. NSAID zachikhalidwe, monga ibuprofen ndi naproxen, zimayambitsa mavuto a m'mimba kuphatikizapo zilonda zam'mimba .
NSAID izi ndizomwe zimasokoneza, kutanthauza kuti zimaletsa onse COX-1 ndi COX-2. Kuletsedwa kwa COX-2 ndi NSAID za chikhalidwe kumathandiza kuti zitsutsane zake, koma chokhumudwitsa ndicho chiletso cha COX-1 chingayambitse zotsatira monga zilonda, nthawi yambiri ya magazi ndi mavuto a impso.
COX-2 NSAID Zosankha
Chakumapeto kwa zaka za m'ma 1990, makampani osokoneza bongo adayambitsa mankhwala angapo omwe amayang'aniridwa ndi COX-2 okha, ma NSAID awa anali Celebrex, Vioxx, ndi Bextra.
Mwa izi, Celebrex ndiyo mankhwala okha omwe amakhala pamsika ku United States ndipo ali ndi bokosi lakuda kuti limakhala ndi chiopsezo cha mtima ndi kupwetekedwa.
Kuchokera pamene Vioxx adachotsedwa mu 2004, bungwe la US Food and Drug Administration linayang'anitsitsa gulu lonse la mankhwala, kuphatikizapo NSAID zonse ndi COX-2 inhibitors zomwe zinagulitsidwa pamsika kapena mankhwala, ndipo zinawonjezeranso machenjezo a bokosi lakuda .
Zina ziwiri zina za COX-2 inhibitors, Arcoxia ndi Prexige, zomwe zikugwiritsidwa ntchito m'mayiko ena, zakanidwa ndi FDA. Prexige anachotsedwa pamsika ku Australia ndi Canada chifukwa cha zovuta za chiwindi.
Ofufuza ena amakhulupirira kuti, pambuyo popeza khungu la COX-2 m'matenda ena osapsa, COX-2 ingathandizenso ntchito zina zomwe thupi limaphatikizapo kupatula kutupa. Ofufuza ku UK apeza kuti COX-2 ingateteze ku matenda a atherosclerosis, nthawi yachipatala yowumitsa mitsempha, kupopetsa ndi kutseka.
Ngakhale kuti NSAID ndi COX-2 inhibitors amaonedwa kuti ndizofunika kwambiri kwa odwala matenda a nyamakazi , ubwino ndi ngozi ziyenera kuganiziridwa kwa wodwala aliyense. Matenda a mtima ndi mtundu wabwino wa NSAID wogwiritsira ntchito ayenera kuyesedwa.
> Zosowa
> Arthritis Foundation. NSAIDs.
> Bathon, Joan M. Kukambirana kwa Makhalidwe Ochepa a COX-2. Johns Hopkins Nyamakazi ya Amayi.
> Kirkby N, Lundberg M, Wright W, Warner T, Paul-Clark M, Mitchell, J. COX-2 Amateteza Kuteteza kwa Atherosclerosis Mwachindunji wa Local Vascular Prostacyclin: Kudziwika kwa COX-2 Associated Pathways Implicate Rgl1 ndi Lymphocyte Networks. PLOS One. June 2, 2014.