Kodi N'chiyani Chimachititsa Kuti Anthu Azisiyana?
Zorvolex ndi mlingo wotsika, mawonekedwe othamanga mofulumira a diclofenac, ndi NSAID (mankhwala osagwiritsidwa ntchito ndi anti-inflammatory drugs). Anavomerezedwa kuti athe kuchiritsidwa ndi ululu wa osteoarthritis mu 2014. Nchiani chimasiyanitsa ndi mitundu ina ya diclofenac ndi zina za NSAID?
Zorvolex, yopangidwa ndi Iroko Pharmaceuticals, LLC, idavomerezedwa kuti athe kuchiritsidwa mopweteka pang'ono ndi anthu akuluakulu.
Chivomerezo cha kupweteka kwa osteoarthritis ndi chitsimikizo chowonjezerapo, Popeza kuti mankhwala osamalidwa ndi mankhwala onse ndi othandiza kwambiri kwa munthu aliyense, adalandiridwa ngati njira yatsopano ya odwala matenda a osteoarthritis.
Mitundu ya Diclofenac
Kodi Zorvolex zimasiyana bwanji ndi diclofenac yeniyeni ndi mawonekedwe a dzina, Voltaren , yomwe ndi mawonekedwe a diclofenac, ndi diclofenac yeniyeni? Zorvolex imapangidwa ndi submicron particles ya diclofenac. The submicron particles ndi pafupifupi 20 pang'onopang'ono kusiyana ndi kukula kwa mankhwala ena a diclofenac. Submicron particles, yopangidwa pogwiritsa ntchito SoluMatrix Fine Particle Technology, imalola mankhwala kuti asungunuke mwamsanga. Zorvolex ndi nSAID yoyamba ya mankhwala osakanikirana (antisteroidal anti-inflammatory drug) yomwe ikugwiritsidwa ntchito pogwiritsa ntchito SoluMatrix Fine Particle Technology yomwe yavomerezedwa ndi FDA.
Kufunika kwa NSAIDs zochepa
NSAID ya dose yaing'ono imathandiza kuyankha machenjezo ndi madandaulo a FDA.
Zaka zingapo zapitazo, a FDA anasintha ndi kuwonjezereka machenjezo kwa mankhwala onse a NSAID. Zinanenedwa momveka bwino kuti ma NSAID amathandizidwa ndi chiopsezo chowonjezeka cha mavuto a mtima (mwachitsanzo, kupweteka kwa mtima ndi kupwetekedwa mtima) komanso kupha magazi m'mimba . Panthawi imeneyo, zida ziwiri za COX-2 zosankha - Vioxx (rofecoxib) ndi Bextra (valdecoxib) - zinachotsedwa pamsika, koma zambiri zidatsalira.
A FDA adalangizanso madokotala kuti alangize (ndi odwala kuti agwiritse ntchito) mlingo wotsika kwambiri wa NSAID kwa nthawi yayitali yomwe ingatheke, pokambirana cholinga cha chithandizo.
Ulamuliro / Mlingo
Mlingo woyenera wa Zorvolex (mankhwala osokoneza bongo) kwa ululu wa osteoarthritis ndi 35 mg. katatu patsiku. (Zindikirani: Zisapositiki za Zorvolex sizimasinthasintha ndi mapiritsi kapena mapiritsi a diclofenac. Mlingo ndi mphamvu sizili zofanana.) Zorvolex 35 mg. ndi buluu wa buluu ndi wobiriwira omwe ali ndi IP-204 omwe amaikidwa pa thupi ndi 35 mg mu kapu ya inki yoyera.
Kutenga Zorvolex ndi chakudya kungachepetse mphamvu - sizinaphunzirepo. Komanso, odwala omwe amadziwika ndi matenda a chiwindi amatha kukhala ndi kusintha kwa mlingo.
Zochitika Zowonongeka Zowonongeka
Malingana ndi mayesero a kachipatala, zochitika zovuta kwambiri zokhudzana ndi Zorvolex zikuphatikizapo edema, nthenda, kupweteka mutu, chizungulire, kusanza, kudzimbidwa, pruritis, kutsekula m'mimba, flatulence, kupweteka pamapeto, kupweteka m'mimba, sinusitis, kuwonjezeka kwa ALT (alanine aminotransferase), kuwonjezeka kwazi creatinine, kuthamanga kwa magazi, ndi indigestion.
Contraindications
Odwala omwe sayenera kutenga Zorvolex ndi awa: omwe ali ndi hypersensitivity odziwika kuti diclofenac; odwala omwe ali ndi mphumu, ming†™ oma, kapena mankhwala enaake atatha kumwa aspirin kapena NSAID iliyonse; ndipo omwe ali ndi ululu wogwirizanitsidwa ndi mitsempha yamakono opitirira opaleshoni yachitsulo.
Chenjezo ndi Kusamala
Zowonongeka zomwe zimagwirizanitsidwa ndi NSAID zina zonse, pokhudzana ndi chiopsezo chowonjezeka cha zochitika za mtima ndi zilonda za m'mimba ndi kutuluka kwa magazi, zimagwiranso ntchito ku Zorvolex. Chenjezo liyenera kugwiritsidwa ntchito ngati odwala omwe ali ndi mbiri yakale ya zilonda za m'mimba kapena kutuluka magazi akulamulidwa ndi Zorvolex. Kuyezetsa magazi kwa chiwindi chiyenera kuchitidwa nthawi ndi nthawi kuti muwone zolakwika. Odwala omwe amatenga Zorvolex ayenera kuyang'anitsanso chifukwa cha matenda oopsa, kusungunuka kwa madzi, mpweya, ndi impso . Matenda a Anaphylactoid ndi owopsa a khungu ndizotheka.
Zorvolex sayenera kuthandizidwa ndi aspirin chifukwa chochita zimenezi zingapangitse chiopsezo cha m'mimba kutuluka m'mimba.
Mofananamo, Zorvolex sayenera kutengedwa ndi anticoagulants chifukwa iyenso idzawonjezera ngozi. Ngati mutatenga kale ACE inhibitor, diuretic, lithium, cyclosporine, kapena methotrexate , chenjezo liyenera kugwiritsidwa ntchito chifukwa kugwirizana kwa mankhwala kungachitike.
Kwa amayi omwe ali ndi pakati, maphunziro a zinyama adawulula kuti Zorvolex ingawononge mwanayo. Pambuyo pa masabata makumi atatu ndi atatu, mankhwalawa sayenera kutengedwa. Kafukufuku adawonetsanso kuti mankhwalawa akhoza kupezeka mu mkaka wa amayi okalamba.
> Zotsatira:
> Kufotokozera Zambiri. Zorvolex. Yofalitsidwa August 2014.
> FDA ikuvomereza Zorvolex kwa Chithandizo cha Mafupa Osteoarthritis. HCPLive. August 25, 2014.