Hyaluronan Injections for Knee Osteoarthritis

by Carol Chilungamo

Zinthu Zomwe Muyenera Kudziwa Zokhudza Hyaluronan

Majekeseni a Hyaluronan ndiwo mankhwala opatsirana osteoarthritis a bondo . Matenda a osteoarthritis ndi matenda osokoneza omwe amakhudza kwambiri katemera. Mapeto a mafupa awiriwa ndi ophatikizana oyenera omwe ali ndi khungu, kulola mafupa kuti agwirane. Cartilage imathandizanso kwambiri.

M'magulu a osteoarthritis , monga katemera akutha, synovial madzi amasintha ndipo amalephera kuthetsa mgwirizano.

Kupweteka, kuuma, ndi zochepa zoziyendetsa kwa mgwirizano wokhudzidwa ndi zotsatira za kuwonongeka. Mankhwala omwe amachititsa hyaluronan mu bondo, omwe amadziwika kuti viscosupplementation, ndi kuyesetsa kuwongolera mafuta a bondo, kuchepetsa kupweteka, ndi kusintha njira zambiri. Pano pali zinthu 10 zomwe muyenera kudziwa za jekeseni ya hyaluronan.

1 - Panopa pali hyaluronates zisanu zomwe zimavomerezedwa ndi US Food and Drug Administration.

Majekesiti a Hyaluronan amaonedwa kuti ndi mankhwala kapena mankhwala. Viscosupplementation for osteoarthritis yakhala ikuphunzira kuyambira m'ma 1970. Mu 1997, ma hyaluronates awiri oyambirira adavomerezedwa ndi a FDA ndipo ena atatu adachokera ku FDA. Mndandanda wa jekeseni wa hyaluronan yotsatira ikutsatira ndi tsiku lawo lovomerezeka:

Hyalgan - May 28, 1997
Synvisc - August 8, 1997
Supartz - January 24, 2001
Orthovisc - February 5, 2004
Euflexxa - 3 December 2004

Synvisc-One - February 26, 2009

2 - Hyaluronan kawirikawiri si mankhwala oyamba a mafupa a bondo.

Kawirikawiri, majakisoni a hyaluronan (omwe nthawi zina amawatcha kuti viscosupplements) akulimbikitsidwa kwa odwala omwe sanapeze kupweteka kokwanira kochokera kuzinthu zowonjezereka za mankhwala:

Mankhwala

Kuchita masewero olimbitsa thupi / mankhwala
Kulemera kwa msinkhu ngati wodwala ali wolemera kwambiri
Kutentha ndi kuzizira
Zida zothandizira (monga, ndodo)

Ngakhale kuti majekisoni a hyaluronan samalangizidwa asanayese njira zina zothandizira , zotsatira zabwino zimapezeka ngati wodwala ali m'zaka zoyambirira za osteoarthritis. Odwala m'magulu ochepa a osteoarthritis, omwe angakhale akudikirira opaleshoni ya mawondo , amaonedwa kuti ndi abwino kwa jekeseni wa hyaluronan kotero iwo akuyembekeza akhoza kupeza mpumulo akudikirira.

3 - Njira yothandizira mitundu iwiri ya jekeseni ya hyaluronan imasiyana.

Chithandizo chonse cha Synvisc, Orthovisc , kapena Euflexxa chimafuna majekeseni atatu osiyana a mawondo omwe amaperekedwa sabata limodzi. Onse awiri Hyalgan ndi Supartz amafuna jekeseni zisanu zosiyana zomwe amapatsidwa sabata limodzi. Izi zimaperekedwa ndi dokotala kapena opaleshoni ya mafupa ku ofesi yawo. Maondo awiri kapena awiri akhoza kulandira nthawi yomweyo. Kuwonjezeredwa kwa Synvisc-One ku roketi mu 2009 kunapangitsa kuti jekeseni ikhale yabwino, ndikusowa majekesiti amodzi okha.

4 - Kodi majekisoni a hyaluronan amatsutsana bwanji?

Maphunziro a zachipatala apeza kuti jekeseni wa hyaluronan ikhoza kuchepetsa kupweteka ndi kupititsa patsogolo ntchito kwa odwala omwe ali ndi mitsempha yowongoka kwambiri ya bondo.

Ngakhale akatswiri ena amatsutsa mfundoyi ndipo akusonyeza kuti maphunzirowa anali olakwika mwa njira ina, madokotala ena amakhulupirira kuti palibe yankho lomveka bwino ngati jekeseni ya hyaluronan ili yabwino kwambiri kuposa injection za corticosteroid kapena mankhwala oyankhula . Palibe umboni umene umasonyeza kuti majeremusi a hyaluronan amakhudza njira yovuta ya matenda. Zili bwino kuti jekeseni si mankhwala.

5 - Pakati pa odwala omwe anathandizidwa ndi jekeseni wa hyaluronan, pamene kupweteka kwapweteka kunachitika.

Kupuma kwapweteka kwambiri kunachitika patatha masabata 8 mpaka 12 mutayika jekeseni yoyamba kwa odwala ambiri. Kafukufuku wasonyeza kuti Synvisc ndi Hyalgan amapereka chithandizo cha kupweteka kwa osteoarthritis ya knee kwa miyezi isanu ndi umodzi, ndipo odwala ena amapeza mpumulo kwa nthawi yaitali.

Supartz inasonyezedwa mu maphunziro kuti apereke chithandizo cha kupweteka kwa miyezi 4 1/2 pambuyo pa jekeseni lachisanu.

Odwala amatha kubwereza mankhwala omwe ali ndi jekeseni wa hyaluronan. Mwachitsanzo, wodwala amene wakhala akuvutika kwa miyezi isanu ndi umodzi kuchokera ku Synvisc koma wakhala ndi ululu wobwerera angakhale wodzitsidwira kwa injini ina ya Synvisc.

6 - Kuchepetsa zotsatira zomwe zingayambitse, atalandira jekeseni odwala ayenera kupeŵa ntchito zovuta kwa maola 48.

Zotsatira zofala kwambiri kuzungulira jekeseni, yomwe nthawi zambiri imakhala yofatsa, ndiyi:

kupweteka kwapangidwe kanthawi kochepa
kutupa
kufiira ndi kutentha
kuyabwa
kuvulaza

7 - Majakisoni a Hyaluronan ndi a FDA okha omwe amavomerezedwa ku matenda osteoarthritis a bondo.

Tsiku lina, mankhwalawa angagwiritsidwe ntchito pochizira ziwalo zina zomwe zimakhudzidwa ndi osteoarthritis. Majekesiti a Hyaluronan pamapewa, mchiuno, ndi mchiuno akuphunziridwa.

8 - Wodwala sayenera kusiya mankhwala ena omwe akuwapeza akamalandira jekeseni wa hyaluronan.

Sitiyenera kuyanjana ndi mankhwala ena opweteka kapena mankhwala otsutsa-kutupa omwe wodwalayo akutenga.

9 - Onse a Medicare ndi inshuwaransi yapadera akubwezera mtengo wa zipangizo zamankhwala ndi njira zomwe zimaonedwa kuti ndizofunikira mthupi.

Pakali pano, Medicare idzaphimba jekeseni wa hyaluronan pa bondo lokha. Medicare imakhalanso ndi umboni wa x-ray wa knee osteoarthritis. Medicare ikhoza kuphimba majekeseni a hyaluronan ngati sangapereke mofulumira kuposa miyezi isanu ndi umodzi. Inshuwalansi yapadera ingakhale ndi malamulo osiyana kotero nthawi zonse ndi bwino kuyang'ana. Nthawi zonse funsani zosintha za Medicare.

10 - Pali zifukwa zofunika kwambiri zotetezera kuti musagwiritse ntchito jekeseni wa hyaluronan.

Odwala akufuna kuyesa Synvisc, omwe amatsutsana ndi zinthu za mbalame (ie, nthenga, mazira kapena nkhuku), ayenera kulankhula ndi dokotala wawo. Odwala ayenera kupatsanso dokotala wawo miyendo yotupa kapena yodwala. Komanso, majekisoni a hyaluronan sanayesedwe kwa ana, amayi apakati, kapena amayi oyamwitsa.

_Zotsatira:

_{Kodi Viscosupplementation Ndi Chiyani?} _{Clinical Cleveland.} _7/28/2007. _{http://www.clevelandclinic.org/health/health-info/docs/3300/3363.asp?index=11428}

_{Malangizo a Medical Management of Osteoarthritis a Hip ndi Knee.} _{American College of Rheumatology.} _7/26/2007. _{http://www.rheumatology.org/publications/guidelines/oa-mgmt.asp?aud=mem}