Kodi Bevyxxa (betrixaban) ndi chiyani?

Chifukwa chiyani Bevyxxa Yalembedwa

Bevyxxa, yomwe imatchedwanso betrixaban, ndi magazi omwe amavomerezedwa ndi Food and Drug Administration kuti agwiritsidwe ntchito pa odwala kuchipatala. Kuyankhula mwaluso, mankhwalawa ndi Factor Xa inhibitor, kutanthauza kuti Bevyxxa amachedwa kuchepetsa magazi kuti athetse.

Ndikofunikira kwa moyo kuti magazi apangidwe, apo ayi tikanafa mpaka titatha kupumula komwe sitimasiya magazi, kapena kuchokera kumphuno yamagazi.

Ngati magazi sanatseke, sitidzakhala ndi moyo wochepa kwambiri, koma magazi omwe amatha kutuluka bwino amachititsanso mavuto aakulu.

Kwa odwala kuchipatala, chiopsezo cha mitsempha ya magazi nthawi zambiri chimakhala chachikulu kuposa chiopsezo chokhala ndi magazi ambiri. Pa chifukwachi, mankhwala amaperekedwa kuti "azipopera" magazi ndikupanga magazi kutenga nthawi yaitali kuti aphimbe. Izi zikhoza kulepheretsa mapangidwe a thupi.

Kodi Bevyxxa Kodi

Magazini amagazi amagwiritsidwa ntchito kuti magazi atenge nthawi yaitali kuti apange ma clot, omwe angachepetse chiopsezo chachikulu chowopsya ndi chowopsa chomwe chimayambitsidwa ndi magazi. Ngakhale kuti anthu ambiri amatenga magazi tsiku ndi tsiku chifukwa cha matenda a mtima omwe amadziwika kuti amawombera, Bevyxxa imagwiritsira ntchito kuteteza mtundu wosiyana wa mankhwala omwe amawoneka nthawi zambiri pakapita kuchipatala.

Nthawi zambiri magazi amatha kupangidwa pamapeto, makamaka miyendo, yomwe imadziwika kuti deep vein thrombosis (DVT) .

Nthawi zina, chovala chomwe chimapangidwa mwendo kapena mkono chidzasuntha ndi kuyamba kuyenda m'magazi, malo ogona m'mapapo pomwe imakhala chiopsezo chotchedwa pulmonary emobolism , kapena PE.

Kwa odwala kuchipatala omwe sakuyembekezeredwa kuchitidwa opaleshoni, Bevyxxa imasonyezedwa pofuna kupewa kuteteza magazi mu chipatala komanso pambuyo poyeretsa.

Asanavomerezedwe ndi Bevyxxa, panali mankhwala awiri ogwiritsidwa ntchito mofanana, Heparin ndi Lovenox (enoxaparin). Mankhwalawa amagwiritsidwa ntchito kuchipatala, koma amapatsidwa ngati jekeseni kotero kuti odwala ayenera kusintha mankhwala osiyanasiyana kuti agwiritsidwe ntchito kunyumba.

Mosiyana ndi Heparin ndi Lovenox, Bevyxxa ikhoza kugwiritsidwa ntchito kuchipatala ndipo pambuyo poyeretsa kuti zisawonongeke, monga mankhwala amatengedwa ngati pilisi, osati monga jekeseni.

Chifukwa Chiyani Bevoxxa Imagwiritsidwa Ntchito

Bevyxxa yavomerezedwa ndi a FDA kuti amasulidwe kwa anthu onse ndipo adzawonekera muzipatala ndi pharmacies kuti zigwiritsidwe ntchito kwa anthu omwe ali pangozi yopanga magazi. Odwala ogwira ntchito kuchipatala ali ndi chidziŵitso chowonjezeka chodzipangira magazi, ndipo wodwalayo, makamaka, amakhala ndi chiopsezo chachikulu. Pa chifukwa chimenechi, nthawi zambiri mankhwala amaperekedwa pofuna kupewa kupangika kwa magazi.

Momwe Bevyxxa Imasiyanirana

Pofufuza, Bevyxxa inali yabwino kwambiri kuposa injini ya Lovenox (enoxaparin). Kusiyanitsa kwenikweni pakati pa Bevyxxa ndi mankhwala omwe akugwiritsidwa ntchito tsopano ndifupipafupi ya dosing ndi njira ya kayendedwe.

Heparin kawirikawiri imaperekedwa kawiri kapena katatu pa tsiku ndipo ndi jekeseni. Lovenox ndi jekeseni ndipo imaperekedwa kamodzi patsiku.

Kuonjezerapo, majekeseni sangathe kupitilira pakhomo ndipo wodwala ayenera kusinthidwa kupita ku mankhwala osiyana-njira yomwe ingabweretse kuchipatala chokwanira nthawi zina-kotero phindu lenileni la Bevyxxa ndilo kuti wodwalayo angathe kutenga zonsezi chipatala ndi kunyumba.

Mtengo wa mankhwalawa sunayambe kulengezedwa kuyambira mwezi wa July 2017, kotero sichidziwika ngati mtengowu ndi wokondana ndi mankhwala omwe akukakamiza a Heparin ndi Lovenox. N'zosatheka kuti mankhwala atsopanowa akhale otsika mtengo kuposa Coumadin (warfarin), yomwe imapezeka mwachibadwa.

Ziyembekezeredwa kuti Bevyxxa idzakhala mpikisano wamtengo wapatali ndi mankhwala ena atsopano opatsirana magazi omwe amachotsedwa pa mapiritsi kunja kwa chipatala, monga Eliquis, Pradaxa ndi Xarelto.

Momwe Bevyxxa Imatengedwa

Bexxxa imatengedwa ndi pakamwa piritsi, makamaka ndi chakudya, kamodzi pa tsiku. Ndi bwino kumwa mankhwalawa panthawi yomweyo tsiku lililonse.

Ngozi za Bevyxxa

Monga onse ochepa magazi, Bevyxxa yowonjezera mwayi wokhala ndi magazi. Izi zikhoza kutanthauza kuti bala labwinobwino, monga percutut, lidzawuluka kwambiri komanso motalika kusiyana ndi momwe mungayankhire musanayambe kumwa mankhwalawa. Kudula kakang'ono pamene kuveketsa kungapangitse magazi ochulukirapo kusiyana ndi momwe amachitira, ndipo zimakhalanso zofanana ndi kusamba kwa mimba kapena kuvulaza. Izi ndizidziwitso zotenga kutenga onse ochepa magazi ndipo sizowonekera kwa Bevyxxa.

Bevyxxa alibe wothandizira kusintha, kutanthauza kuti palibe mankhwala omwe amadziwika omwe amachititsa zotsatira za Bevyxxa kusiya nthawi yomweyo ngati magazi atuluka. Izi zingachititse kuti zikhale zovuta kuti asiye kutuluka magazi ngati kuvulazidwa koopsa, kutuluka m'magazi kapena mitundu ina yazigawo zamagazi. Ngati kutaya mwazi kuli koopsa kapena kuopseza moyo, kuika magazi m'malo mwa kutayika magazi kumakhala mankhwala othandiza kwambiri.

Kudandaula kungakhalenso kofunika kwambiri pamene mutenga mankhwala a Bevyxxa kapena mtundu uliwonse wa mankhwala ochepetsa magazi. Zotsatira zina sizikugwirizana ndi magazi pamene mayesero a mankhwalawa akuphatikizapo:

• Matenda a m'matope (UTI)
• Kutsekedwa
• Pasiziyamu ya pansi
• Kuthamanga kwa magazi
• Mutu
• Nausea
• Kutsekula m'mimba

Nthawi yoitanira Dokotala Wanu

Ngakhale kuti magazi ambiri ndi ochizira ndi ochepa magazi, si zachilendo kukhala ndi magazi muchitetezo chanu, chomwe chimatchedwa melena. Sizowonongeka kuti muwone magazi mumtambo wanu, ndikuwonetseranso kuti kutuluka magazi sikuchitika. Pamodzi ndi zizindikirozi, pansipa pali zitsanzo zina za nthawi yoti muwone dokotala ponena za kugwiritsa ntchito magazi owonda:

• Mutu wamphamvu
• Chizungulire kapena zofooka zosadziwika
• Kupweteka kosadziŵika bwino, kuphatikizapo kupweteka pamodzi
• Mphuno zamadzimadzi
• Kutsekemera kofuula

Ngati mutenga Bevyxxa kwambiri, pitani kuchipatala kapena pitani kuchipatala chapafupi.

Ngati mukumana ndi mdima wamdima kapena masabata, vomani ndikuwona zomwe zimawoneka ngati malo a khofi, kapena muli ndi mitsempha yamagazi (pinki, yofiira, kapena yaukodzo), muyenera kutchula wothandizira zaumoyo mwamsanga.

Kuvulazidwa kumutu kulikonse, monga kugwa kumene kumayambitsa mutu, kuyenera kuchitikanso. Ndizosavuta kukhala ndi kachilombo ka ubongo pa ubongo mukamamwa mankhwalawa, ndipo chithandizo chofulumira chayamba bwino zotsatira zake zomaliza.

Amene sayenera kumwa

• Monga mankhwala onse opatsirana magazi, Bevyxxa sayenera kutengedwa ndi wina aliyense amene ali ndi magazi othamanga.
• Mankhwala awa sanaphunzire kuti agwiritsidwe ntchito pa odwala.
• Bexxxa siinaphunzirepo kuti igwiritsidwe ntchito kwa amayi apakati kapena amayi oyamwitsa. Gwiritsani ntchito amayi omwe ali ndi mimba kapena anamwino ayenera kuganiziridwa pamene phindu lopukuta magazi ndi lalikulu kuposa kuopsa kwake. Popeza Bevyxxa sinaphunzirepo poyamwitsa amayi, ndibwino kupewa kutsegula mwanayo kwa mankhwala ndi kugwiritsa ntchito mkaka wothandizira m'malo mwake.
• Odwala omwe ali ndi vuto lokhala ndi magazi samayenera kumwa mankhwalawa.
• Odwala ndi matenda a impso angafunike kuchepa kwa mlingo wa tsiku ndi tsiku.
• Anthu omwe amadziwika ndi matenda a chiwindi sayenera kugwiritsa ntchito mankhwalawa. Matenda a chiwindi angachepetse mphamvu ya thupi kuti iphimbe ndipo ingayambitse mavuto aakulu pamene mukumwa mankhwalawa.
• Odwala omwe ali ndi mavava amtima sanaphunzirepo, choncho sadziwa ngati mankhwalawa ndi othandiza kwa anthu amenewo.
• Odwala omwe ali pa Bevyxxa ndipo adzakhala ndi msana kapena epidural anesthesia ali pa chiopsezo chachikulu cha hematoma, mndandanda waukulu wa magazi pa malo otsekedwa. Ngakhale izi sizikumveka ngati nkhani yaikulu, pamakhala zovuta kwambiri izi zikhoza kuwononga mitsempha kapena ngakhale ziwalo.
• Azimayi omwe ali ndi zaka zakubadwa za mwana ayenera kugwiritsa ntchito mankhwalawa mosamala pamene akusiya kusamba akhoza kukhala ofunika ndi mankhwalawa. Azimayi okhala ndi magazi ochulukirapo amatha kukhala ndi magazi m'thupi kapena ngakhale kutaya magazi ndi mankhwalawa kapena magazi ochepa. Ngati mukukonzekera kutenga mimba, kambiranani nanu ndi dokotala wanu.
• Odwala amene akumwa mankhwala ena omwe amadziwika kuti amachititsa kuti magazi asatayike, monga aspirin, mankhwala ena ovutika maganizo, ibuprofen ndi naproxen , ndi ena omwe ali ndi magazi omwe ali ndi chiopsezo chachikulu chakumayambitsa matenda otha magazi.

Kusokoneza Chidwi

Zomwe zimachitika ndi Bevyxxa ndi mlingo woyamba wa 160 milligrams (mg) wotsatira mlingo wa 80 mg. Mankhwala ayenera kuchepetsedwa kwa odwala omwe ali ndi matenda aakulu a impso. Mankhwala awa aphunzitsidwa kuti agwiritsidwe ntchito masabata asanu kapena asanu, nthawi yaitali yogwiritsiridwa ntchito ndi kotheka, koma chidziwitso sichinapezeke.

Bexxxa ilipo mu 40mg kapena 80 mg mlingo mphamvu. Odwala omwe amamwa mankhwalawa, omwe ali P-glycoprotein inhibitors, amafunika mankhwala ochepa a Bevyxxa:

• Amiodarone (Cordarone)
• Azythromycin
• Clarithromycin
• Cyclosporine
• Colchicine
• Diltiazem
• Erythromycin
• Felodipine
• Ketoconazole
• Lansoprazole (Prevacid)
• Omeprazole (Prilosec)
• Nifedipine (Procardia)
• Paroxetine (Paxil)
• Sertraline (Zoloft)
• Quinidine
• Tamoxifen
• Verapamil

Ngati Muphonya Dose wa Bevyxxa

Ngati mwaphonya mlingo wa mankhwalawa, ndipo mlingo wanu wotsatira ndi maola asanu ndi atatu kapena oposa, mutenge mlingo wosaphonya. Apo ayi, muyenera kudumpha mlingo ndi kutenga mlingo wanu wotsatira monga mwadongosolo.

Mawu Ochokera

Bevyxxa ndi mankhwala atsopano ovomerezedwa ndi FDA mu June 2017 kuti agwiritsidwe ntchito kwa odwala omwe sali opaleshoni pakapita kuchipatala komanso pamene akuchira. Panthawi ino yolembayi, Bevyxxa sichipezeka kwa anthu onse. Ngakhale zotsatira zoyambirira kuchokera ku maphunziro omwe amachitika pa mankhwalawa akulonjeza, zowonjezereka zokhudzana ndi kugwiritsidwa ntchito kwa nthawi yayitali, zotsatira zake, zoopsa ndi zopindulitsa zidzakhalapo pamene odwala ambiri amagwiritsa ntchito mankhwalawa.

Panthawiyi, kafukufuku amasonyeza kuti mankhwalawa amathandiza kuti odwala asamapitirire kuchipatala komanso pakatha masabata omwe amachiritsidwa, ndipo ndi othandiza kwambiri kuposa mankhwala ena ofanana.

> Chitsime:

> Bwerani. Mfundo zazikulu Zopereka Mauthenga. Chakudya ndi Mankhwala Osokoneza Bongo. Idapezeka mu June, 2017. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208383s000lbl.pdf