Kafukufuku Akufotokoza Zizindikiro
Kufufuzira kwa kuchepa kwazinyalala kosadziwika bwino - kumatchedwanso kuti kusagwirizana kwa gluten - mochuluka kumatsimikizira kuti mungathe kupeza zizindikiro zoopsa zowonongeka ndi gluten popanda matenda a leliac .
Pa kafukufuku wochititsa chidwi wokhudzidwa kwamtundu wa gluten wotulutsidwa kumayambiriro kwa chaka cha 2011, kafukufuku wotchuka wa a Celiac Dr. Alessio Fasano anamaliza kunena kuti "kutengeka kwa gluten" kumaimira chikhalidwe chosiyana kwambiri ndi matenda a leliac, ndipo ambiri omwe amadwala matenda a gluten sadzakhala ndi laliac.
Ngakhale kuti kafukufuku wake ndi ofunika kwambiri kwa achipatala, ndizofunika kuzindikira kuti kafukufuku wake sanayambe kufotokozedwa ndipo kotero madokotala ambiri akuwonabe kuti izi ndi chiphunzitso cha chitukuko.
Dr Fasano ndi gulu lopangidwa ndi ochita kafukufuku wa matenda a Celiac, kuphatikizapo Drs. Peter Green (mkulu wa bungwe la Columbia University Celiac Disease Center) ndi Dr. Marios Hadjivassiliou (katswiri wa zamagulu ndi a katswiri wa adatisi ya gluten ), adatsatira phunziro loyamba ndi mawu ogwirizana omwe anatulutsidwa mu February 2012 akulongosola njira zothetsera kusiyana kwa matenda a leliac, gluten kukhudzidwa, ndi gluten ataxia.
Ofufuza ena aphatikiziranso apeza zotsatira. Kafukufuku wina amasonyeza kuti anthu ena omwe ali ndi vuto la gluten ali ndi mafilimu ofanana omwe amapezeka kuti ali ndi ziwalozi, zomwe zikusonyeza kuti pangakhale chikhalidwe chisanafike. Kafukufuku wina kumbuyo kwa Dr. Fasano zomwe anazipeza kuti gluten angayambitse zizindikiro kwa anthu omwe alibe matenda achikali.
Kafukufuku wokhudzidwa kwa gluten akuyamba mofulumira. Kuonjezera apo, mobwerezabwereza, anthu omwe ali ndi vuto labwino la magazi laliliac koma vuto loipa limaperekedwa kuti azindikire kuti ali ndi mphamvu zowonongeka.
Nthawi zina, dokotala wawo amatha kudya zakudya zowonongeka, kapena amauzidwa kuti azitsatira zakudya zopanda thanzi koma sayenera kukhala odwala monga odwala.
Ena amauzidwa kuti ali "otheka" odwala matenda a celiac, ndi kubwereranso chaka chimodzi kapena kupitilira kukayezetsa kuti awone ngati ali ndi vutoli.
Kafukufuku wambiri adzafunika kudziwa ngati anthu omwe ali ndi mphamvu ya gluten amatha kuchepa pang'ono, kapena ngati kachilombo kakang'ono kamene kamakhala ndi matenda a gluten chidzapitirizabe kukhala ndi matenda a celiac.
Werengani zambiri momwe zingakhalire zoopsa zokhudzana ndi umoyo wa gluten: Gluten Sensitivity Health Risks
U. wa Maryland Pegs 'Gluten Sensitivity' ngati Chikhalidwe Chake
Mu kafukufuku wa Dr. Fasano oyambirira wokhudzidwa ndi chidwi, adasindikizidwa pa intaneti mu March 2011 mu BMC Medicine , ofufuzawa adapeza kusiyana kwakukulu pakati pa matenda a leliac ndi kutentha kwa gluten pa maselo, ngakhale kuti zizindikiro za zinthu ziwirizi zinagwedezeka kwambiri.
Dokotala Fasano ndi ena ofufuza a University of Maryland anayerekezera 42 omwe anapeza kuti ali ndi Marsh 3 kapena Marsh 4 kuwonongeka kwa m'mimba ndi anthu 26 omwe m'matumbo awo amawonongeka pang'ono kapena ayi, koma omwe adayimbenso bwino ndi gluten.
Kwa ophunzira onse, ofufuza anapeza kukula kwa matumbo (mu matenda a celiac, matumbo anu amatha kupitirira, omwe amalola kuti mapuloteni athawire mumtsinje wa magazi).
Anayang'aniranso za majini, komanso majeremusi m'matumbo aang'ono.
Kafukufukuyu anapeza kusiyana pakati pamimba pakati pa magulu a anthu, kuphatikizapo kusiyana kwa majeremusi omwe amachititsa kuti chitetezo cha mthupi chitetezeke. Izi zimasonyeza kuti mphamvu ya gluten imakhala yosiyana ndi matenda omwe ali ndi matendawa , malinga ndi Dr. Fasano.
Kusiyanasiyana kwa tsinde la Celiac, Gluten Sensitivity From System Immune System Yankho
Kusiyana pakati pa zinthu ziwirizi zimachokera ku mayiko osiyanasiyana a chitetezo cha mthupi, Dr Fasano akuti.
Maganizo a gluten, machitidwe a chitetezo cha m'magazi - mbali yakale ya mawonekedwe a chitetezo cha mthupi ndi mzere woyamba wa chitetezo kwa owononga - amachititsa kuti chakudya cha gluten chisamangidwe mwakumenyana ndi gluten mwachindunji.
Izi zimapangitsa kutupa mkati ndi kunja kwa thupi, monga Dr. Fasano.
Pakalipano, matenda a leliac amatenga mawonekedwe a chitetezo cha chitetezo cha mthupi komanso chitetezo cha chitetezo cha mthupi, akuti. Mmene thupi limagwiritsira ntchito chitetezo cha m'magulu ndi njira yowonjezera, yowonjezereka kwambiri ya maselo a chitetezo cha m'thupi.
Anthu omwe ali ndi vuto la gluten sakhala ndi ziphuphu zowopsya, ngakhale kuti amatha kukhala ndi zizindikiro zofanana ndi zofiira, kuphatikizapo kutsekula m'mimba , kupweteka m'mimba , kupweteka m'mimba , kupweteka kwa m'mimba, ubongo ndi migraines, malinga ndi Dr. Fasano. (Werengani zambiri zowonjezera zizindikiro apa: Chizindikiro cha Gluten Sensitivity .)
Komabe, anthu okhawo omwe ali ndi chitetezo cha chitetezo cha mthupi omwe amachitapo kanthu mosiyana ndi matenda a celiac ali pachiopsezo choyamba m'mimba yamatumbo ndi zina zomwe zimakhudzana ndi leliac, monga matenda a mitsempha , Dr. Fasano akuti.
Ena mwa anthu omwe ali ndi vuto la gluten omwe anaphatikizidwa mu phunziro la Dr. Fasano anali ndi kuwonongeka kwa m'matumbo pang'ono (kutchulidwa ngati Marsh 1 kapena 2 ), koma kuwonongeka kumeneku kunali ndi zosiyana kwambiri ndi zomwe zimawoneka mu matendawa.
Okhoza 'Odwala Omwe Amagawanika Amagawikana Ndi Mankhwala Opangidwa ndi Mankhwala Osiyanitsa ndi Zolemba Zake
Palinso kafukufuku wina amene amachititsa kuti anthu ena atchulidwe kuti "gluten-sensitive" angakhale ndi matenda oyambitsa matendawa.
Kafukufuku amene adafalitsidwa mu December 2010 Journal of Proteome Research akupeza kuti odwala omwe ali ndi "mayeso " omwe ali ndi mayeso abwino a magazi koma ali ndi zizindikiro zosaoneka bwino zomwe ali nazo zimakhala zofanana ndi zojambulazo. Anthuwa "omwe amadziŵa" gluten "amangoimira gawo loyambirira la matendawa asanawononge kwambiri matumbo, ochita kafukufukuwo adanena.
Phunziroli linagwiritsira ntchito magnetic resonance malingaliro opatsirana pogwiritsa ntchito mavitamini a m'magulu a m'magazi ndi magazi a odwala 141: 61 ndi matenda a celiac, 29 omwe amawayeza bwino magazi koma ali ndi mphamvu zowonongeka.
Iwo adapeza kuti omwe ali ndi matenda omwe amachititsa kuti "angathe" matendawa amagawidwe ndi ziwalo zofanana ndi zomwe zimapezeka kuti zimapezeka, pomwe mbiri ya biochemical ya machitidwe abwino amasiyana kwambiri.
"Zotsatira zathu zimasonyeza kuti kusintha kosokoneza bongo kungayambitse chitukuko cha m'mimba chochepa chakumimba ndipo chimapereka zowonjezereka kwa kuyambitsa kwa GFD [zakudya zopanda zakudya za gluten] kwa odwala omwe ali ndi vuto [la celiac]] la CD."
Chisamaliro cha Gluten Chotheka Pakati pa Odwala Amene Ali ndi Mipata Yopsereza
Kafukufuku wina ankayang'ana odwala omwe ali ndi zizindikiro za matenda a leliac omwe matumbo a m'mimba amasonyeza zochepa chabe, monga Marsh I kapena II zilonda .
Madokotala ambiri sangathe kupeza matenda a kilisiyo kupatula kupweteka kwa m'mimba kukufika pa Marsh III kapena Marsh IV .
Phunziro ili, odwala 35 anali ndi vuto lochepa ndipo adalangizidwa kuti atsatire zakudya zopanda thanzi. Odwala 23 okha amatsatira chakudya ndipo ochita kafukufukuwo amatsatira zochitika zotsatila kuchokera kwa aliyense kutsata zakudya pambuyo pa miyezi eyiti kapena 12.
Odwala onse 23 omwe adatsata chakudyacho "adakula kwambiri," ndipo ambiri adawona machiritso athunthu kapena amagazi a m'mimba mwawo.
Odwala asanu ndi awiri mwa anthu 11 omwe anakana kutsatira zakudya za gluten anayesedwa miyezi 8 kapena 12 pambuyo pake. Mwa izi, asanu ndi limodzi anali ndi zizindikiro zosasintha ndi kuwonongeka kwa m'mimba ndipo adayambanso kudya zakudya zopanda thanzi. Mmodzi anawona kuwonjezeka kwa ubongo wake m'mimba (kuyambira Marsh I mpaka Marsh IIIa) ndipo anasankha kuyambitsa zakudya.
Olemba apeza kuti odwala omwe sanagwirizane ndi matenda a celiac anali othetsera thanzi komanso amapindula ndi zakudya zopanda thanzi.
"Ngakhale kuti Marsh I-II zilonda sizingatheke kukhala zilembo zamakono, zizindikiro za odwala patsikulo komanso kusintha kwabwino kwa zizindikiro pa GFD [zakudya zopanda zakudya za gluten], kapena popanda zong'onoting'ono zamatenda a histologic, zimachirikiza kuganiza kuti odwala awa ali ndi vuto la gluten ndipo akhoza kulondola chithandizo ndi GFD, "anatero ochita kafukufukuyo.
Kumva Chisamaliro cha Gluten May Lingakhudze Mmodzi mwa Anthu 14
Kutsimikizika kwa Gluten (kapena kusagwirizana) kungakhudze 6 peresenti mpaka 7 peresenti ya anthu, malinga ndi Dr. Fasano. Ena m'magulu a zamankhwala aika chiwerengero cha anthu osasamala kwambiri a gluten - Ndawona chiwerengero cha 10% kufika ku 50% ya anthu ambiri.
Werengani zambiri pa manambala awa: Ndi Anthu Angati Ambiri Amene Amakhala ndi Gluten Sensitivity?
Ndizosatheka kunena kuti ndi anthu angati omwe ali ndi mphamvu zowonjezera za gluten popanda kufufuza ndi kulandira mayesero achidziwitso a gluten . Koma momveka bwino, ngakhale chiwerengero chiri kumbali yotsika, iwo amachepetsa chiwerengero cha celiacs, omwe amapanga pafupifupi 1% mwa anthu.
Ambiri mumtundu wotchedwa laliac / gluten amakhulupirira kuti matenda omwe amayamba ndi mchere amadzipangitsa okha kukhala ndi matenda a "gluten", ndi matenda a leliac, a gluten ataxia (kuwonongeka kwa mitsempha ya gluten) komanso kukhwima kwa gluten onse akugwa kwinakwake pamtundu umenewu.
Dr. Fasano akuti chinthu chotsatira ndicho kudziwika kwa chilengedwe, kapena "biomarker," chifukwa cha kutengeka kwa gluten . Chiyeso cha kuchipatala kuti chichite chomwecho chikuchitika pakalipano, ndipo Dr Fasano akuti ali ndi "chidaliro" ochita kafukufuku adzatsimikizira kuti biomarker. Kuchokera kumeneko, ofufuza akhoza kupanga mayeso kuti azindikire kutengeka kwa gluteni - zomwe zingakhale zogulitsidwa m'zaka zingapo zotsatira.
> Zotsatira:
> Bernini P. et al. Kodi Odwala Amene Angathe Kudwala Matenda Omwe Angathe Kugonjetsa? Yankho la Metabonomics. Journal of Research Proteome. Idasindikizidwa pa Intaneti Nov. 19, 2010. DOI: 10.1021 / pr100896s.
> J. Biesiekierski et al. Gluten Zimayambitsa Zisonyezo za M'mimba M'magulu Opanda Matenda Odziwika: Kachilombo kawiri kamene kamakhala kosawerengeka. American Journal of Gastroenterology ikupita patsogolo pa Intaneti, Jan. 11, 2011; do: 10.1038 / ajg.2010.487.
> A. Fasano et al. Kuchulukana kwa Kutsekedwa kwa Gut ndi Mucosal Kufotokozera kwa Mthupi la Immune M'zochitika Zachiwiri Zogwirizana ndi Ulemelero: Matenda a Celiac ndi Gluten Sensitivity. BMC Medicine 2011, 9:23. lembani: 10.1186 / 1741-7015-9-23.
> Fasano A. et. al. Kuwonetsa kwa Matenda Okhudzana ndi Ziphuphu: Kugwirizana pa Dzina Latsopano ndi Malemba. BMC Medicine. BMC Medicine 2012, 10:13 chiku: 10.1186 / 1741-7015-10-13. Lofalitsidwa: 7 February 2012
> Tursi A. et al. Yankho lachidziwitso ndi zaumulungu kwa chakudya cha Gluten popanda odwala omwe ali ndi matenda ovuta kulowa m'mimba. Journal of Clinical Gastroenterology. 2003 Jan; 36 (1): 6-7.