Njira Yoyamba Kuzindikira
Kuyesedwa kwa matenda a chililili nthawi zambiri kumayamba ndi mayeso a magazi. Mayesowa amayang'ana momwe thupi lanu limayendera kwa gluten , mapuloteni omwe amapezeka tirigu, balere, ndi rye omwe amachititsa matenda a celiac.
Kuyesera magazi sikungwiro. Ngati kuyesera magazi kwanu kulibe, kumatanthauza kuti simungathe kukhala ndi matenda a celiac, komabe pali mwayi wapang'ono kuti mukhale nawo.
Ngati kuyesa magazi kuli koyenera, zikutanthauza kuti mumakhala ndi matenda a celiac, ngakhale kuti nthawi zambiri mumakhala ndi chithandizo chamankhwala chotchedwa endoscopy kuti mutsimikizidwe.
Pogwiritsa ntchito mankhwalawa, dokotala wanu adzaika chubu m'mimba mwathu ndi pamwamba pa katumbo wanu kakang'ono, ndipo mudzadula zitsulo zing'onozing'ono kuchokera m'kati mwa matumbo anu kuti muwone pansi pa microscope. Ngati zitsanzo za minofu zikuwonetseratu kuopsa kwa atrophy , khalidwe lopweteka m'mimba limapezeka mu matenda a chilili, ndiye kuti muli ndi vutoli.
Inde, nthawi yayitali, ndipo zonse zimayamba ndi kuyesera magazi.
Ndi Mayesero Otani a Magazi Amene Amachitidwa
Kuyeza kwa magazi koyake kumayang'ana ma antibodies omwe amasonyeza momwe chitetezo cha mthupi lanu chimayankhira kwa gluten pa zakudya zanu-ndicho chifukwa chake mukuyenera kudya gluten pamene mukuyesedwa matenda a chilliac. Ngati simukudya zakudya zowonongeka pa nthawi ya kuyesedwa, kuyezetsa magazi sikungakhale kosavuta ngakhale mutakhala ndi matendawa.
Pali mayesero asanu a magazi omwe mukanakhala mutayesedwa pa matendawa:
- AGA (antitigliadin antibodies) -AgA
- AGA-IgG
- TTG (anti-tissue transglutaminase) -AgA
- EMA (anti-endomysial antibodies) -AgA
- Total seramu IgA
Inde, iwo onse amawoneka ngati mchere wolemba. Koma mayeso onsewa ayang'ane mbali zina za chitetezo cha mthupi lanu kuti awone ngati thupi lanu likuchita mapuloteni a gluten mu chakudya chimene mukudya.
Pa mayesero onsewa, kuyesedwa kwa magazi a EMA-IgA kumatengedwa kuti ndiyeso yeniyeni yochuluka ya magazi kwa matenda a celiac, kutanthauza kuti ngati muli ndi zotsatira zabwino pa EMA-IgA, mwinamwake muli ndi matenda a celiac. Komabe, EMA-IgA ikhonza kuphonya anthu ena omwe ali ndi matendawa, makamaka ngati atangoyamba kumene.
Ngati mukukhudzidwa ndi mfundo zamakono: EMA imayimira antiendomysial antibodies, zomwe zimagwiritsidwa ntchito ndi thupi lomwe limayambitsa minofu ya thupi. IgA, kapena immunoglobulin A, ndi mtundu wamba wa antibody wopangidwa ndi thupi lanu. Ntchito yake ndi kuthandiza thupi kuti lidziwe ndikulimbana ndi anthu omwe akukumana nawo, monga poizoni, mabakiteriya, ndi mavairasi.
Mayesero Ena Otheka Osavuta
Kuyeza kwa magazi komwe kumatchedwa AGA-IgA, AGA-IgG, ndi tTG-IgA kungasonyezenso kuti thupi lanu likuchita puloteni ya gluten ... ndipo akhoza kuzindikira anthu ena omwe ali ndi matenda a celiac omwe amayesedwa moyenera kwambiri EMA-IgA amasowa.
Komabe, mayeserowa angapangitse zowonongeka, komwe kumayesedwa ndi zotsatira zabwino, koma munthuyo alibe matenda a celiac. Ichi ndi chifukwa chake akatswiri ena odwala matendawa amachititsa mayesero onse pamodzi - mukhoza kupeza chithunzi chokwanira momwemo.
Nthaŵi zina, anthu omwe ali ndi matenda a shuga, mtundu wa chithokomiro , ndi matenda a chiwindi a autoimmune amatsitsimutsa pa imodzi mwa mayeserowa, mayeso a tTG-IgA, chifukwa cha zifukwa zina. TTG imayimira mnofu transglutaminase, mavitamini omwe amapezeka m'matumbo.
Kuyeza magazi kwa tTG-IgA kumasonyeza kuti thupi limapanga tizilombo toyambitsa matenda, zomwe zingatheke chifukwa cha kuluma kwa gluten. Komabe, sizikutanthauza kuti muli ndi matenda a Celiac, makamaka ngati muli ndi zina mwazimenezo. Kotero ngati muli ndi zina zoterozo, dokotala wanu angayang'ane mosamala kwambiri zotsatira za mayeso ena a magazi a celiac.
Pomalizira, gulu loyesa magazi lija likuphatikizapo kuyesa kuyang'ana kuchuluka kwake kwa wodwala wina, immunoglobulin A, thupi lanu limapanga. Izi ndizofunikira chifukwa anthu omwe ali otsika mu anti-antibody (omwe amadziwika kuti IgA) akhoza kukhala ndi zotsatira zoipa pa kuyesedwa kwa magazi a Celiac, ngakhale ali ndi vutoli.
Ndipo, izi ndizofunikira kwambiri chifukwa anthu omwe ali ndi matenda a leliac amavutika ndi vutoli, omwe amadziwika kuti IgA , omwe amapezeka nthawi zambiri, kuposa 10 kapena 15 kuposa anthu ambiri.
Madokotala ena amagwiritsanso ntchito chimodzi mwa mayeserowa- antigen - antigen-IgG, kapena AGA-IgG- anthu osindikizira omwe amatha kuzindikira mphamvu za gluten . Komabe, ochita kafukufuku asonyeza kuti sizolondola kwenikweni pa cholinga chimenecho, ndipo pakalipano, asayansi sanayese mayeso olondola a kutengeka kwa gluten.
Kuyesedwa kwachibadwa kwa Gene
Madokotala ena amalimbikitsanso kuyesa majeremusi ena omwe amawonjezera chiopsezo chanu chokhala ndi matendawa. Ngati mutayamba kale kudya zakudya zopanda thanzi , izi zingakhale zokhazo dokotala wanu akukulimbikitsani kuthamanga (mayesero omwe ndalongosola pamwambapa sali olondola pokhapokha mutadya gluten).
Mayeso a jini okhaokha sakuyang'ana ma antibodies a gluten; M'malo mwake, amayang'ana majini awiri, HLA-DQ2 ndi HLA-DQ8 , zomwe zakhudzana ndi matenda a celiac. Majini anu samasintha, ngakhale mukudya zakudya za gluten.
Tsopano, kuyesera kwa majini koliyake sikukutanthauza kuti muli ndi matenda a celiac-kumangotanthauza kuti muli ndi "zenizeni" kuti mukhale ndi vutoli. Ngati mayeso ena a magazi ndi ofunika koma mayeso anu a geni ndi othandiza, inu ndi dokotala wanu mungasankhe kuti musamaye kudya gluten kwa nthawi yoyesera kuti muwone ngati zizindikiro za matenda a leliac zikuwonekera.
Zotsatira:
Kuyeza kwa Serologic ndi Genetic. Celiac Disease Center ku Columbia University Medical Center.
University of Maryland Malo Ofufuza Kwambiri. Matenda a Celiac: Mafunso Omwe Amafunsidwa