Zindikirani Kuopsa Kwanu Kukulitsa Matenda Aakulu
Matenda a Celiac akugwirizanitsidwa ndi chibadwidwe, kutanthauza kuti iwe ukhoza kukhala ndi laliac ngati mutanyamula ma jini omwe amakulowetserani. Choncho, madokotala akugwiritsanso ntchito ntchito yoyezetsa magazi kuti athe kudziwa ngati wina ali ndi chikhalidwe choyambitsa matendawa.
Pafupifupi aliyense amadya gluten, mapuloteni omwe amapezeka mu tirigu, balere ndi rye.
Komabe, mwa anthu omwe ali ndi majeremusi oyenera, kupweteka kwa gluten kumatha kumabweretsa matenda a celiac, omwe amachititsa kuti maselo oyera a magazi akulimbana ndi matendawa amenyane ndi chifuwa cha m'matumbo ako.
Sikuti aliyense amene amanyamula matenda amtunduwu amatha kukhala ndi matenda a celiac. Ngakhale kuti anthu 40% ali ndi jini imodzi kapena awiri, oposa 1% aliwonse ali ndi matenda a celiac. Choncho kukhala ndi mphamvu zokhudzana ndi majini sikukutanthauza kuti mudzapezeka ndi matenda a celiac ndipo muyenera kusiya gluten; Ndipotu, zowonjezera zimapangidwira.
Komabe, kuyezetsa kwa majeremusi kwa matenda a leliac kungapereke kachidutswa kenakake ku chithunzithunzi cha matenda, makamaka pamene matenda anu sakuwoneka bwino kapena pamene mukuyesa kupeza zosowa za m'tsogolo.
Matenda a Kachilombo Omwe Amayambitsa Matenda Achibadwa Amawoneka Zachiwiri Zachibadwa
Khalani ndi ine-izi zimakhala zovuta.
Majeremusi omwe amakuchititsani kuti mukhale ndi matenda enaakewa ali pa chipangizo cha HLA-II cha DNA yathu, ndipo amadziwika ngati majeremusi a DQ.
Aliyense ali ndi makope awiri a DQ gene-imodzi kuchokera kwa amayi awo ndi imodzi kuchokera kwa abambo awo. Pali mitundu yambiri ya majeremusi a DQ, koma pali ziwiri zomwe zimakhudzidwa kwambiri ndi matenda a Celiac: HLA-DQ2 ndi HLA-DQ8 .
Mwa izi, HLA-DQ2 ndi yofala kwambiri pakati pa anthu ambiri, makamaka pakati pa anthu okhala ndi European heritage-anthu 30% kapena ochulukirapo omwe makolo awo amachokera ku mbali ya dziko lapansi amanyamula HLA-DQ2.
HLA-DQ8 imaonedwa kuti ndi yosawerengeka, ikuwonekera pafupifupi 10 peresenti ya chiwerengero cha anthu onse, ngakhale kuti ndizofala kwambiri kwa anthu ochokera ku Central ndi South America.
Kafukufuku wasonyeza kuti pafupifupi 96 peresenti ya anthu omwe amapezeka ndi chiopsezo ndi matenda a celiac amanyamula DQ2, DQ8 kapena kuphatikizapo awiriwo. Popeza muli ndi DQ imodzi yochokera kwa mayi anu ndi imodzi kuchokera kwa bambo anu, n'zotheka kuti mukhale ndi ma DQ2 awiri, makope awiri a DQ8, kopi imodzi ya DQ2 ndi imodzi ya DQ8, kapena kopi imodzi ya DQ2 kapena DQ8 kuphatikizapo wina DQ jini.
Mulimonsemo, ngati mutanyamula kopi imodzi ya DQ2 kapena DQ8, mukuganiza kuti muli ndi chiopsezo chachikulu cha matenda a celiac. Pali umboni wina woti kunyamula makope awiri a majini (mwina DQ2 kapena DQ8) kungakulepheretseni ngozi zambiri.
Kafukufuku wina wasonyeza kuti jini yeniyeni, HLA-DQ7 , imayambitsanso anthu ku matenda ena okhaokha. Ndipotu, mu phunzirolo, 2% mwa anthu omwe ali ndi matendawa omwe amatsimikiziridwa ndi biopsy amanyamula HLA-DQ7, koma osati DQ2 kapena DQ8. Komabe, pali kutsutsana pa nkhani yoti DQ7 kwenikweni imakuchititsani kudwala matendawa, ndipo kuyesa kwa majeremusi ku US sikuzindikira DQ7 ngati "matenda oopsa a matendawa."
Kuonjezera apo, kufufuza kwatsopano kukuwonetsani kuti simukuyenera kunyamula HLA-DQ2 kapena HLA-DQ8 kuti mukhale ndi mphamvu zowonongeka zopanda ululu .
Pakhoza kukhala zowonjezereka za majeremusi a HLA-DQ okhudzidwa ndi mphamvu ya gluten; werengani zambiri mu Kodi mukusowa majeremusi enieni kuti mukhale ndi mphamvu zowonjezera za gluten?
Kuyeza kwachibadwa kwa Gene Kumaphatikiza Zowonekera Zowonekera
Kuyesedwa kwa matenda a chililili sizowonongeka konse. Mukhoza kupereka labotala ndi chitsanzo cha magazi anu, pogwiritsira ntchito swabu kuti mutenge maselo pang'ono kuchokera mu tsaya lanu, kapena mugwiritse ntchito syringe kapena vial kuti mutenge makola ena. Magazi anu, masaya kapena masaya ndiye amafufuzidwa ndi labotale; Njira iliyonse iyi imabweretsa zotsatira zolondola.
Anthu ambiri ali ndi mayeso a ma genetiki omwe amachitidwa mogwirizana ndi mayesero ena omwe adalangizidwa ndi dokotala wawo.
Komabe, n'zotheka (ngakhale kuti ndi okwera mtengo) kuti mupeze mayeso popanda dokotala kukhala nawo.
Pali malo awiri omwe mungayese kuyesedwa popanda dongosolo la dokotala: Enterolab, labotale yapadera ku Dallas ( Enterolab imayesetsanso kuyesedwa kwa mphamvu ya gluten ), komanso kuyesa machitidwe a ma genetic 23andMe.com.
Pafupifupi madola 150 (amalipidwa panthawi yomwe mumayika), Enterolab adzasanthula majini anu ndikukuuzani za majeremusi a HLA-DQ omwe mumanyamula, kuphatikizapo ngati mumanyamula chimodzi mwazirombo zamtunduwu. Kuyezetsa kumachitidwa ndi maselo omwe amasonkhanitsidwa ndi swab mkati mwa tsaya lanu, kotero palibe kukopa kwa magazi komwe kumakhudzidwa. Mukasungunula tsaya lanu ndi kutumiza pazitsanzo zanu, zotsatira zimatumizidwa kwa inu mkati mwa masabata atatu.
Ndi 23eMe.com, mumakhala malovu ndi kutumiza viala kuti muyesedwe. Kampaniyi imapereka mayeso a ma ARV omwe ali ndi "Health and Ancestry", omwe amawononga madola 200. Lipoti lanu lidzaperekanso zambiri zokhudza makolo anu, ndi deta zokhudza ma genetic.
Kuyezetsa magazi sikuli kofanana
Popeza si onse omwe amanyamula mphepo yamtundu wa diliyiti yomwe imapezeka ndi matenda a celiac (anthu ambiri sakhala ndi vutoli ngakhale ndi jini, kwenikweni), kuyesera kwa ma genetiki sikufanana ndi matenda. (Onani: Ndinayesedwa bwino mu mayesero anga a jekeseni.) Kodi ndiyenera kupita ku gluten? )
Matenda anu onse omwe ali ndi matenda a chilliki ndi omwe mumawapeza ngati madokotala omwe amawawona kuti ndi "owopsa kwambiri". Choncho, matenda opatsirana pogonana omwe ali ndi matendawa amathandiza kwambiri kuti asatulukidwe matendawa. Nthawi zina, munthu akhoza kukhala ndi zotsatira zoyesera zomwe sizimveka bwino, ndipo kuyesa kwa jini kungathandize dokotala kupeza matenda oyenera.
Kuyeza kwa Gene kumathandizanso kuthetsa matenda a chililiyali m'mabanja omwe amapezeka kuti ali ndi matendawa. Kuyezetsa magazi kwa achibale kukulimbikitsidwa kamodzi ngati wina m'banja mwanu atapezeka, koma ngati mukudziwa kuti mukudwala matenda a leliac, muyenera kutsatira kwambiri.
Pomaliza, n'zotheka kugwiritsa ntchito mayeso a jini kuti awone ngati matendawa ndi otheka kwa wina amene akudya zakudya zopanda thanzi .
Mukuyenera kudya gluten kuti muyesedwe moyenera. Komabe, anthu ena amazindikira kuti kudya kwa gluten kumapangitsa kuti amve bwino, komanso kuchotsa mapuloteni a gluten kuchokera ku zakudya zawo asanayese matenda a celiac. Pambuyo pake akaganiza kuti akufuna kugwiritsidwa ntchito, ali ndi zisankho ziwiri: yesetsani vuto la gluten , kapena ayese kuyezetsa magazi.
Simukusowa kudya gluten kwa matenda a gayalini-yesero, yesero limangokhala ngati mutha kukhala ndi matenda enaake, osati ngati muli nawo. Choncho, ngakhale kuyesedwa kwa majeremusi sikungapereke mayankho omveka bwino ngati muli ndi matenda a celiac, anthu ambiri amakonda vuto la gluten chifukwa safuna kuti abwerere ku gluteni kuti adziwe zambiri zokhudza matenda awo.
Pali zambiri zomwe sitikudziwa zokhudza matenda a leliac, ndipo sizowoneka bwino chifukwa chake anthu ena omwe ali ndi matenda amtunduwu amakula koma ena samatero. Komabe, matenda a chilondawa amathandiza kuti adziŵe chiopsezo cha mkhalidwe mwawo, komanso nthawi zomwe sizikudziwika bwinobwino.
Zotsatira:
Celiac Disease Center ku Columbia University. Kuyeza kwa Serologic ndi Genetic. Idapezeka pa Jan. 5, 2012.
National Institutes of Health. Msonkhano wa NIH Consensus Development pa Matenda Ovuta. Idapezeka pa Jan. 5, 2012.
Sacchetti L. et al. Kusiyanitsa pakati pa Matenda a Celiac ndi ena a m'mimba muubwana ndi Rapid Human Lymphocyte Antigen Typing. Clinical Chemistry. Aug. 1998, Vol. 44, No. 8, tsa. 1755-1757.
Chipatala cha Chicago Celiac Disease Center. Mayeso a Zachibadwa . Idapezeka pa Jan. 5, 2012 ..