Jini HLA-DQ7 sichikudziwika kuti ndi imodzi mwa majeremusi akulu omwe angathe kukupangitsani kuti mukhale ndi matenda enaake . Koma pali umboni wina wotsimikizira kuti ukhoza kuthandizira, komanso mwinamwake wosasamala .
Matenda a Celiac ndi chikhalidwe cha chibadwa, chomwe chimatanthauza kuti muyenera kukhala ndi majini "abwino" kuti muwone. Ochita kafukufuku apeza kuti majeremusi anu a HLA-DQ akuwoneka kuti amachititsa kuti chiwonongeko cha m'mimba chiwonongeke m'mimba.
HLA-DQ Genes ndi Matenda a Celiac
Khalani ndi ine: izi zimakhala zovuta komanso zosokoneza.
Aliyense adzalandira majeremusi awiri a HLA-DQ kuchokera kwa makolo awo-mumalandira kuchokera kwa amayi anu ndi amodzi kuchokera kwa abambo anu.
Pali mitundu yosiyanasiyana ya majeremusi a HLA-DQ, kuphatikizapo HLA-DQ7, HLA-DQ2 , HLA-DQ8 , HLA-DQ9 ndi HLA-DQ1 . Mukhoza kulandira majeremusi awiri a HLA-DQ osiyanasiyana (zochitika zofala kwambiri), kapena mlingo wachiwiri wa jini limodzi la HLA-DQ (chinthu chosazolowereka kwambiri).
Kuchokera mwa mitundu yonse yosiyanasiyana ya majeremusi a HLA-DQ, pali ziwiri zomwe zimatchedwa " matenda amtundu wa celiac :" HLA-DQ2 ndi HLA-DQ8 yochepa. Anthu ambiri omwe amapanga matenda a Celiac ali ndi HLA-DQ2, ndipo peresenti yaing'ono ndi HLA-DQ8. Ma jini awiriwo amaoneka kuti amawerengera pafupifupi 96 peresenti ya aliyense amene ali ndi matenda a celiac.
Momwe HLA-DQ7 Imalowera
Pali anthu ena omwe samanyamula HLA-DQ2 kapena HLA-DQ8 ndipo amapitirizabe kukhala ndi matendawa.
Kafukufuku wina apeza kuti pafupi theka la anthu awa (mwachitsanzo, pafupifupi 2% mwa anthu onse omwe ali ndi matenda a celiac) kwenikweni amanyamula HLA-DQ7.
Izi zikuwonetsa HLA-DQ7 ingakhale jini lomwe lingapangitse anthu ena kukhala ovuta.
Komabe, lingaliro limeneli silinagwirizane ndi maphunziro ena, ndipo kufufuza kwina kuli kofunika kudziwa ngati HLA-DQ7-yomwe ili yofanana ndi HLA-DQ8 -diyeni ikhoza kutsogolera ku matenda a celiac, ngakhale mulibe imodzi za "ziwalo zazikuluzikulu za matenda a mphere." Panthawiyi, madokotala ambiri samaganiza kuti HLA-DQ7 ndi matenda a celiac.
N'zotheka kuti HLA-DQ7 imathandizira kukhala ndi mphamvu zowonongeka, zomwe zimawoneka kuti n'zosiyana ndi matendawa (ngakhale kuti matendawa ndi ofunika kwambiri).
Dr. Kenneth Fine, yemwe anayambitsa njira yoyesera kugwiritsira ntchito gluten yomwe imagwiritsidwa ntchito ku Enterolab (yogwiritsira ntchito mwachindunji), yasonkhanitsa deta ya HLA-DQ kwa odwala ambiri a Enterolab. Iye watha, pogwiritsa ntchito kafukufuku wake wosasindikizidwa, kuti HLA-DQ7 imakulozerani kuti mukhale ndi mphamvu zowonongeka. Komabe, mankhwala ochiritsira amachepetsa kafukufukuyu chifukwa sanafalitsidwe ndi kuyesedwa.
Zonse ndizokayikira kuti pali majeremusi ochulukirapo ambiri okhudzana ndi chitukuko cha matenda a celiac, koma ochita kafukufuku sakuzindikira zonsezi. Kafukufuku wokhudzidwa ndi matenda a gluten akungoyamba kumene, ndipo asayansi sanazindikire ngati ndilo vuto limene limakhala lochokera ku maina.
Zotsatira:
Sacchetti L. et al. Kusiyanitsa pakati pa Matenda a Celiac ndi ena a m'mimba muubwana ndi Rapid Human Lymphocyte Antigen Typing. Clinical Chemistry. Aug. 1998, Vol. 44, No. 8, tsa. 1755-1757.
University of Maryland Chigawo cha Kafukufuku Wachidziwitso. Matenda a Celiac Ofunsidwa Kawirikawiri.