Mosiyana ndi matenda a chilili, kutengeka kwa gluten sikukuwoneka kuti kumafunikira ma geneeni enieni
Ngakhale kuti kafukufuku wokhudzidwa ndi zamoyo zamtundu wosasunthika uli chabe kuyamba ndi maphunziro omwe akusonyeza kuti ndizosiyana kwambiri zomwe sizinafotokozedwe, zotsatira zoyambirira zimasonyeza kuti simukusowa kunyamula zina zotchedwa matenda a celiac kuti mupange gluten kukhudzidwa.
Anthu omwe ali ndi matenda a leliac , omwe amamvetsetsa bwino mitundu itatu ya gluten "zovuta," nthawi zambiri amanyamula limodzi mwa majini awiri enieni.
Ndipotu, madokotala nthawi zonse amagwiritsa ntchito kuyesa kwa majeremusi kuti athetse matenda a seliac - ngati mulibe jini lomwe likufunika kuti likhale lolimba, amati, mulibe vutoli.
Maonekedwe a kutsekemera kosaleta kosaleta sakudziwika bwino.
Momwe Majeremusi Amathandizira Udokotala Wodwala
"Matenda a chiwalo" amapezeka pafupifupi 35 mpaka 40 peresenti ya anthu onse, ndipo kuti muli ndi majini sizitanthauza kuti mumakhala ndi matenda a celiac - zimangotanthauza kuti muli ndi mphamvu zowonjezera.
Majini omwe amakuchititsani kuti mukhale ndi matendawa, amadziwika kuti ndi majeremusi a HLA-DQ, ndipo amapezeka pa chipangizo cha HLA-II cha DNA yathu. Aliyense amalandira kabuku limodzi la HLA-DQ gene kuchokera kwa amayi awo komanso kachiwiri kachilombo ka HLA-DQ kuchokera kwa bambo awo.
Pali mitundu iwiri yambiri ya majeremusi a HLA-DQ, otchedwa HLA-DQ1, HLA-DQ2 , HLA-DQ3 ndi HLA-DQ4. HLA-DQ1 ikuphatikizidwanso ku HLA-DQ5 ndi HLA-DQ6, pomwe HLA-DQ3 ikuphatikizidwanso ku HLA-DQ7 , HLA-DQ8 ndi HLA-DQ9.
Popeza aliyense amapeza majini awiri a HLA-DQ (mmodzi kuchokera kwa amayi awo ndi mmodzi kuchokera kwa bambo awo), munthu akhoza kukhala ndi mitundu yambiri yambiri ya ma gene. Ena mwa majeremusiwa amakupangitsani kuti mukhale ndi matenda enaake, pamene kufufuza koyambirira kumasonyeza kuti ma jini ena akhoza kukupangitsani kuti mukhale ndi mphamvu zowonjezera.
Tikudziwa kuti ambiri mwa anthu omwe ali ndi matendawa a HLA-DQ2 kapena HLA-DQ8 (kachigawo ka HLA-DQ3). Komabe, kuyambira 35 peresenti kapena 40 peresenti ya anthu amanyamula imodzi kapena zonse ziwiri za matenda a celiac, kukhala ndi majini sichikutanthauza kuti mumatha kupeza mankhwalawa - pali zinthu zina (zomwe sizinapezeke) zomwe zikuphatikizidwa.
Zachilengedwe Zidalumikizidwa mu Chisokonezo cha Gluten
Pankhani yokhudzidwa kwa gluten, zikuwoneka kuti matenda a leliac samasewera, malinga ndi kafukufuku wina woyambirira.
M'buku lafukufuku wafukufuku wa gluten womwe unatulutsidwa kumayambiriro kwa chaka cha 2011 ndi katswiri wofufuza wa University of Maryland Dr. Alessio Fasano, olembawo anafufuza za majeremusi omwe ali ndi matenda a gluten, ndipo anawayerekeza ndi gulu lina la anthu omwe onse anali ndi "golide chikhalidwe "cha matenda a chililili kudzera m'mayesero a magazi ndi chidziwitso cha magazi.
Ofufuzawa anapeza kuti 56 peresenti ya anthu omwe amapezeka kuti ndi a gluten omwe amachititsa DQ2 kapena DQ8, amasonyeza kuti majini amenewa sagwirizana kwambiri ndi chitukuko cha gluten kuposa momwe amachitira pa chitukuko cha matendawa. Komabe, majini amapezeka nthawi zambiri mwa anthu omwe ali ndi mphamvu zowonjezera kuposa momwe amachitira anthu ambiri, kotero mwina akhoza kukhala ndi mphamvu zowonjezereka - sizikudziwika bwino zomwe angachite.
Inde, madokotala ambiri amafuna kuona zomwe Dr. Fasano anapeza zikufotokozedwa asanavomereze kuti mphamvu ya gluten ilipo. Dr. Fasano akugwira ntchito tsopano kuti adziwe zowonongeka zomwe zingapangitse mayesero a mphamvu ya gluten .
Zina Zachibadwa Zitha Kuphatikizidwa M'kulemberana kwa Ulemerero
Dr. Kenneth Fine, yemwe adayambitsa njira yoyesera ya kuchepa kwa EnteroLab gluten , akuti akukhulupirira kuti aliyense amene ali ndi majeremusi HLA-DQ2 ndi HLA-DQ8 "adzabweretsa gluten ku chitetezo cha mthupi kuti athane - mwachitsanzo, kukhala ndi gluten."
Koma omwe ali ndi HLA-DQ2 ndi HLA-DQ8 si okhawo omwe amamva mphamvu zowonongeka, Dr. Fine akuti.
Amakhulupirira kuti aliyense amene ali ndi HLA-DQ1 ndi HLA-DQ3 nayenso amaloledwa kukhala ndi mphamvu zowonjezera. Izi zikutanthauza kuti anthu okha omwe ali ndi mavoli awiri a HLA-DQ4 (osachepera 1% a anthu a ku United States) alibe mphamvu zowonongeka, monga Dr. Dr. Fine. Malinga ndi lingaliro lake, ena onse ali ndi mphamvu zowonjezera kuti zikhale ndi vutoli.
Anthu omwe ali ndi makope awiri a majeremusi, monga HLA-DQ7 (mawonekedwe a HLA-DQ3 omwe ali ofanana ndi HLA-DQ8), omwe amawopsya kwambiri kwa gluten, monga momwe anthu okhala ndi makope awiri a HLA-DQ2 angathe kukhalira kolimba kwambiri matenda, iye akunena.
Kumbukirani, kufufuza kwa Dr. Fine sikunayankhidwe ndi ena omwe akuphunzira za chibadwa cha mphamvu ya calcium ndi gluten, kotero sizodziwika ngati izo zidzatsimikiziridwa kapena ayi. Komabe, ngati maulosi ake akunena kuti ali olondola, izi zikutanthauza kuti pafupifupi aliyense ku US ali ndi majini oyambirira omwe amafunika kuti azikhala ndi mphamvu zowonjezera. Komabe, popeza si onse omwe ali ndi vutoli (onani mutu wanga wakuti Anthu Ambiri Ali ndi Gluten Sensitivity? ), Payenera kukhala pali zina ndi majini omwe akukhudzidwa.
Mfundo Yofunika Kwambiri
Ofufuza ena akufunikira kutsimikizira zotsatirazi zoyambirira ndi malingaliro awo kuti avomerezedwe kwambiri mchipatala, ndipo pali kukayikira kwakukulu pakati pa madokotala ngati mphamvu ya gluten ilipo konse. Pogwiritsa ntchito zonsezi, kuyesa kwa majeremusi kwa kutengeka kwa gluteni sikungakhale kopindulitsa kapena kotheka mudziko lenileni panthawi ino, ngati kuli konse.
Komabe, Dr. Fasano ndi Dr. Fine, pakati pa anthu ena, akupitirizabe kuphunzira za matenda omwe amachititsa kuti thupi liziyenda bwino. Kafukufuku wawo amasonyeza kuti ngakhale mayeso anu a jekeseni anali oipa, mungathebe kukhala ndi vuto la gluten .
Zotsatira
Tsamba lolembera la EnteroLab: Mafunso Ofunsidwa Kawirikawiri Ponena Kutanthauzira kwa Zotsatira.
A. Fasano et al. Kusokonezeka kwa matumbo kumapangidwe ndi ma genetic immune mucosal m'maganizo awiri ogwirizanitsa: matenda a celiac ndi mphamvu ya gluten. BMC Medicine 2011, 9:23.