Matenda a Celiac ndi chibadwa, chomwe chimatanthauza kuti muyenera kukhala ndi "majeremusi oyenera" kuti mupangidwe ndi kupezeka nawo. HLA-DQ2 ndi imodzi mwa ziwalo zazikuluzikulu zamtundu wa khansa, ndipo zimapezeka kuti ndizofala kwambiri m'thupi lomwe limaphatikizapo mu matenda a leliac (HLA-DQ8 ndi ina yomwe imatchedwa "jekeseni").
Madokotala ambiri amakhulupirira kuti mukusowa kopi imodzi ya HLA-DQ2 kapena HLA-DQ8 kuti mukhale ndi matenda a celiac.
Zofunikira Zachibadwa za Genetics
Genetics ingakhale nkhani yosokoneza, ndipo majini a matenda a celiac amavuta kwambiri. Apa pali tanthauzo losavuta.
Aliyense ali ndi majini a HLA-DQ. Ndipotu, aliyense amalandira makope awiri a majeremusi a HLA-DQ - mmodzi kuchokera kwa amayi awo ndi mmodzi kuchokera kwa atate wawo. Pali mitundu yambiri ya majeremusi a HLA-DQ, kuphatikizapo HLA-DQ2, HLA-DQ8 , HLA-DQ7 , HLA-DQ9 ndi HLA-DQ1 .
Ndi mitundu yosiyanasiyana ya ma HLA-DQ2 ndi HLA-DQ8 yomwe imayambitsa chiopsezo chanu chokhala ndi matenda a leliac.
Popeza aliyense amalandira zamoyo ziwiri za HLA-DQ (imodzi kuchokera kwa kholo lililonse), N'zotheka kuti munthu akhale ndi HLA-DQ2 imodzi (yomwe nthawi zambiri imalembedwa ngati HLA-DQ2 heterozygous), makope awiri a HLA-DQ2 (HLA-DQ2 ogwirizana) , kapena palibe kopi ya HLA-DQ2 (HLA-DQ2 yolakwika).
Komanso, pali mitundu itatu yosiyana ya jini la HLA-DQ2. Mmodzi, wotchedwa HLA-DQ2.5, amapereka chiopsezo chachikulu kwa matenda a leliac; pafupifupi 13 peresenti ya anthu a ku Caucasus a ku US amanyamula jini.
Komabe, anthu omwe ali ndi matembenuzidwe ena a HLA-DQ2 ali pachiopsezo cha matenda a leliac.
Ngati ndili ndi Gene, Kodi Ndingawononge Motani?
Izo zimadalira.
Anthu omwe ali ndi makope awiri a HLA-DQ2 (chiŵerengero chochepa kwambiri cha anthu) amakhala ndi chiopsezo chachikulu cha matenda a celiac. Malingana ndi kafukufuku wa chiopsezo cha eni eni omwe adayambitsa kafukufuku amene adalembedwa ndi machitidwe oyesera ma genetic MyCeliacID, matenda a celiac amapezeka mwa anthu omwe ali ndi ma CD awiri a DQ2 pafupipafupi maulendo 31 a anthu ambiri.
Anthu omwe ali ndi makope awiri a HLA-DQ2 ali ndi chiopsezo chowonjezereka chifukwa cha mtundu umodzi wa matenda a celeacac omwe amatsutsa (omwe amapezeka pamene zakudya zopanda zakudya za gluten siziwoneka kuti zimagwira ntchito kuthetsa chikhalidwe), ndi T -nenani mtundu wa lymphoma , mtundu wa khansara yomwe imakhudzana ndi matenda a leliac.
Anthu omwe ali ndi kachilombo kamodzi ka HLA-DQ2 amakhala ndi chiwerengero cha "chiwerengero cha anthu" omwe amapezeka ku matendawa, mogwirizana ndi MyCeliacID. Anthu amene amanyamula HLA-DQ2 ndi HLA-DQ8, omwe ali ndi matendawa, amakhala ndi chiopsezo cha "chiwerengero cha anthu".
Zinthu Zina Zimakhudzidwa
Sikuti aliyense amene amanyamula HLA-DQ2 amapanga matenda a celiac - majini amapezeka m'mayiko oposa 30% (makamaka omwe ali ndi kumpoto kwa European genetic heritage), koma pafupifupi 1% a ku America ali ndi matenda a celiac.
Ochita kafukufuku amakhulupirira kuti pali mitundu ina yambiri ya majeremusi yomwe imakhudza ngati munthu amene ali ndi kachilombo ka HIV kameneka amakula kwambiri, koma sanadziwebe majini onse omwe ali nawo.
Zotsatira:
Al-Toma A. et al. Mankhwala a Leukocyte Antigen-DQ2 Homozygosity ndi Development of Refractory Celiac Matenda ndi Enteropathy- Yogwirizanitsidwa T-Cell Lymphoma. Clinical Gastroenterology ndi Hepatology. 2006 Mar 4 (3): 315-9.
MyCeliacID Risk Stratification Table. Inapezeka pa March 20, 2012.
Ploski R. et al. Pa HLA-DQ (alpha 1 * 0501, beta 1 * 0201) -magwirizano okhudzana ndi matenda a chililiy: zotsatira zenizeni za jini za DQB1 * 0201. Antigeni Zamatenda. 1993 Apr; 41 (4): 173-7.
Vader W. et al. Mankhwala a HLA-DQ2 omwe amachititsa kuti matendawa akhale okhudzana ndi kukula kwake kwapadera kwa mayankho a T cell. Proceedings of the National Academy of Sciences. 2003 October 14; 100 (21): 12390-12395.