Majini anu ndi ofunikira, komanso pali zina
Sizidziwikiratu zomwe zimayambitsa matenda a leliac . Ndipotu, ambiri ofufuza amakhulupirira kuti pali zinthu zingapo zomwe zimakhalapo, zomwe zingakhale zofunikira kuti chikhalidwe chikhalepo.
Majini anu amathandiza kwambiri - ngati mulibe imodzi mwa majeremusi omwe ali okhudzana ndi matenda a celiac, zimakhala zochepa kwambiri (ngakhale si zero).
Komabe, anthu ochepa (40%) amanyamula chimodzi kapena zonse ziwiri za majini, kotero kuti chibadwa si chokhacho chomwe chikusewera pano.
Kuti mukhale ndi matenda otchedwa Celiac, muyenera kumadya gluten . Pamene muli ndi matenda a celiac, gluten amachititsa chitetezo cha mthupi lanu kuwononga intestine yanu yaing'ono. Komabe, anthu ambiri amadya zakudya zam'madzulo (anthu ambiri amadya zakudya zowonongeka-komanso nthawi zambiri-tsiku lililonse), ndipo anthu oposa 1% amatha kupeza matenda a celiac.
Pomalizira, kuti mukhale ndi matenda achilili, zinthu zomwe zili m'malo mwanu ziyenera kuthandizira. Ndi "zinthu" izi zomwe siziri bwino; anthu ena amatha kudya zakudya zam'madzi tsiku lililonse kwa zaka makumi angapo popanda vuto ndipo kenaka amakhala ndi zizindikiro zoopsa za matendawa , pomwe ana ena amaonetsa zizindikiro zosaoneka ngati zakudya zowonongeka zimayambitsidwa.
Kafukufuku wina amasonyeza kuti kachilombo kawirikawiri kameneka, kamene kamakhala ndi anthu ena, kamathandizira kuti chitukukochi chizikula.
Komabe, phunziroli ndiloyamba ndipo kufufuza n'kofunika kuti tipewe zotsatira zenizeni.
"Yambani" Kungathandize Kupangitsa Matenda a Celiac
Akatswiri ena asayansi amaganiza kuti matenda opatsiranawa amafunika "kuyambitsa," zomwe zingawathandize kukhala ndi thanzi labwino kapena ngakhale kupanikizika kwakukulu; Mwachitsanzo, amayi ambiri amayamba kukhala ndi zizindikiro zolimbana ndi mimba ndi kubadwa, ndipo anthu ena amapeza zizindikiro zawo zimayamba kutsatira matenda omwe akuoneka ngati osagwirizana, kapena amatsata nthawi yovuta pamoyo wawo .
Komabe, izi "zotsutsa" izi sizinatsutsike.
Asayansi ena amaganiza kuti zakudya zomwe timadya zimakhala zowonjezereka m'zaka 40 zapitazo, pamene timadya zakudya zambiri komanso tirigu wokhawokha amakhala ndi makutu akuluakulu omwe amachititsa kuti matendawa asapitirire. Pali umboni wina wotsutsa mfundoyi, chifukwa kafukufuku wina waposachedwapa anapeza kuti chiwerengero cha matenda a leliac chawonjezeka kawiri pazaka 15 kuyambira 1974.
Enanso amaganizira za matenda a silili pa maselo. Kafukufuku waposachedwapa waphatikizapo zizindikiro ziwiri-interleukin 15 ndi retinoic acid, omwe amachokera ku vitamini A-monga omwe angayambitse kupweteka kwa thupi kwa gluten. Ofufuzawa ankayang'ana anthu omwe ali ndi matenda a celiac, ndipo anapeza kuti anali ndi interleukin 15 m'matumbo awo. Akamapangitsa kuti mankhwalawa asamangidwe kwambiri, mbewa zimakhala ndi zizindikiro zoyambirira za matendawa. Acinoic acid inadwalitsa zizindikiro ndi kuwonongeka.
Ofufuzawa atatsegula interleukin 15, komabe, mbewazo zinasinthika ndipo zinkatha kulekerera kachilombo. Izi zinachititsa asayansi kulingalira kuti mapangidwe apamwamba a interleukin 15 m'matumbo anu angayambitse matenda a celiac.
(Zoonadi, sizikudziwikiratu zomwe zingayambitse mapangidwe apamwamba a interleukin 15 kuti akule mumatumbo anu) Komabe, ngati zili choncho, mankhwala omwe amaletsa interleukin 15 (omwe ali kale m'mayesero odwala matenda a nyamakazi) angathandizenso chithandizo matenda a celiac.
Kodi Mungayanjane Pakati pa Celiac ndi Reovirus?
Akatswiri a sayansi adapeza kuti pali chiyanjano pakati pa matenda a leliac ndi mtundu wa tizilombo wotchedwa reovirus. Reovirus imakhudza anthu ambiri, kawirikawiri akakhala makanda, koma amachititsa zizindikiro zochepa kapena zochepa. Phunzirolo, lofalitsidwa mu nyuzipepala ya Sayansi , linagwiritsa ntchito mbewa zomwe zinkagwiritsidwa ntchito makamaka kuti zikhale ndi matenda a leliac.
Ofufuzawa anapeza kuti chitetezo cha mthupi chimatetezedwa m'magulu awo pamene anali ndi kachilomboka kenaka anadyetsa zamoyo.
Ofufuzawo adafufuzanso anthu omwe kale anapeza kuti ali ndi matenda a leliac, akuyang'ana mwapadera kuti apange tizilombo toyambitsa matendawa. Anapeza mabungwe apamwamba kwambiri a reovirus antibodies kwa anthu omwe ali ndi ziwalo ziwiri kapena zisanu kuposa anthu omwe alibe chikhalidwe.
Phunziroli silikuyandikira kuwonetsa kuti reoviruses amachititsa-kapena ngakhale matenda otsekemera. Ochita kafukufuku adzafunika kuchititsa maphunziro ena kuti awone ngati chikugwirizanacho. Komabe, ngati reoviruses amathandizira kuti chitukuko chitheke, ndizotheka kuti katemera angathandize kuteteza anthu omwe ali ndi majeremusi.
Chifukwa cha Matenda a Celiac Sichinawonekere, Ngakhale Kuti Akufufuza
Choncho kuti tilembere, matenda a leliac amayamba chifukwa: kukhala ndi majini oyenera, kudya zakudya za gluten, komanso mwina ndi mtundu wina.
Chiphunzitso chimodzi chomwe sichiri cholondola ndi chodziwika chomwe chikudzudzula kuwonjezeka kwa matenda a celiac ndi kuphulika kosakhala koliyake kwa tirigu wothira mavitamini. Popeza tirigu wosinthidwa ndi mavitamini sali pamsika paliponse, sizingayambe kuwonjezeka .
Komabe, sayansi ya zamankhwala sadziwa zambiri za zomwe zingayambitse, ngakhale kuti izo zikuwoneka kuti ndizofunikira kwambiri chifukwa chake anthu ena ali ndi "majeremusi oyenera" amapanga matenda a leliac pamene ena samatero. Ndipotu, ofufuza ayamba kufufuza njira zosiyanasiyana. N'zodziwikanso kuti pali majeremusi ena omwe sapezeka.
Palibe kukayikira, kuti kudziwa chomwe chimayambitsa matenda a celiac kungathandize mwamsanga kupita patsogolo kwa mankhwala ochiritsira. Alessio Fasano, MD, mkulu wa University of Maryland a Mucosal Biology Research Center ndi Center for Research Celiac, akuti, kufufuza momwe zingayambitsire chilengedwe cha matenda a leliac ndikofunika kwambiri-kuzindikira zifukwa za matenda a celiac kungathandize kulenga chithandizo chamankhwala kapena kuti kupewa matendawo.
Zotsatira:
Bouziat R et al. > Reovirus Infection Amayambitsa Kutupa Kwambiri kwa Matenda Antigeni ndi Kukula kwa Matenda a Celiac. Sayansi . 2017 Apr 7; 356 (6333): 44-50.
Catassi C. et al. Mbiri ya chilengedwe cha matenda a leliac m'magulu a USA kuyambira 1974. Annals of Medicine. October 2010, p. 530-8.
Chipatala cha Chicago Celiac Disease Center. Zizindikiro.
University of Chicago News. Maphunziro a anthu ndi a mbewa amathandizira kuganizira kwambiri chifukwa cha matenda a celiac.
University of Maryland School of Medicine News. University of Maryland Chigawo cha Kafukufuku Wopeza Amapeza Mtengo wa Matenda Odwala Ndikukula.