US ndi European Trial Results Zomwe Zinayambira Glucosamine
Pamsonkhano wa American College wa Rheumatology Year Scientific Meeting (2005), zotsatira za mayesero awiri a glucosamine zinaperekedwa. Zotsatira za mayesero awiriwa zinkayembekezeredwa kwambiri ndi ofufuza, madokotala, ndi odwala omwe anali kufunafuna kutsimikiziridwa kuti glucosamine inali njira yabwino yothetsera nyamakazi .
- GAIT (Glucosamine / Chondroitin Arthritis Testing Invention) Anapatsidwa ndalama ndi National Institutes of Health ndipo cholinga chake chinali kuteteza chitetezo ndi glucosamine ndi chondroitin , atachotsedwa padera kapena palimodzi.
- ZOTHANDIZA (Glucosamine Unum In Die Efficacy) anali kuyesa kwachipatala ku Ulaya.
GAIT (Glucosamine / Chondroitin Arthritis Tested Invention) Gawo I
Mu Gait (Glucosamine / Chondroitin Arthritis Intervention Trial), pafupifupi 1,600 odwala opweteka mafupa osteoarthritis adatengedwa kuchokera ku 16 a US academic rheumatology malo a phunziroli. Ophunzirawo anali atamva ululu waukulu wamondo ndipo anali ndi umboni wa x-ray wa knee osteoarthritis. Phunziro la GAIT, odwalawa:
- Anayesedwa kumayambiriro kwa phunzirolo.
- Anayesedwa pamasabata 4, 8, 16, 24.
- Odwala anali ndi vuto loti alandire glucosamine HCl, sodium chondroitin sulfate, mavitamini onse awiri, celecoxib (dzina lake Celebrex) , kapena placebo.
- Odwala analoledwa kufika 4,000 mg tsiku lililonse la acetaminophen.
Zotsatira Kuchokera ku GAIT (Glucosamine / Chondroitin Arthritis Testing Invention)
- Zotsatira zimasonyeza kuti kuphatikiza kwa glucosamine ndi chondroitin kuli bwino kuposa placebo koma mapindu amaoneka kuti amadalira kuvutika kwa ululu.
- Odwala omwe ali ndi vuto lopweteka la mafupa la osteoarthritis, 79.2% kutenga glucosamine / chondroitin kuphatikizapo kupweteka kwa ululu.
- Kwa odwala omwe amatenga celecoxib, 69.4% amamva kupweteka kwa ululu. Odwala omwe amatenga glucosamine okha, 65.7% adakumana ndi mpumulo, monga momwe anachitira 61.4% odwala kutenga chondroitin okha. Komanso, 54,3% kutenga malo a placebo anafotokoza kupumula kwa ululu.
- Odwala opweteka osteoarthritis, odwala osteoarthritis, glucosamine / chondroitin sanagwiritsidwe ntchito kwambiri kuposa placebo.
ZOTHANDIZA (Glucosamine Unum In Die Efficacy)
Panali odwala 318 mu maphunziro OTHANDIZA ndi knee osteoarthritis (88% akazi). Odwala anali osasamala kuti azitenga kapena kumwa glucosamine sulphate osakaniza ndi ufa (1500 mg kamodzi pa tsiku), acetaminophen (1000 mg katatu pa tsiku), kapena placebo pa miyezi isanu ndi umodzi. Magulu onse analoledwa kutenga ibuprofen ngati pakufunika.
Zotsatira Zokonzedweratu (Glucosamine Unum In Die Efficacy)
- Onse a glucosamine sulfate ndi acetaminophen anali othandiza kwambiri kuchepetsa ululu kuposa placebo.
- Odwala kutenga glucosamine sulphate amasonyeza mpumulo wambiri kusiyana ndi odwala a acetaminophen.
- Zinagwiritsidwa ntchito kuti kamodzi katsiku ka 1500 mg mlingo wa mankhwala a glucosamine sulphate angakhale chithandizo chovomerezeka cha mafupa a m'magazi.
Phase II ndi Phase III GAIT zotsatira
Zotsatira za gawo lachiwiri la phunziro la GAIT zinasindikizidwa mu nyuzipepala ya Arthritis & Rheumatism mu 2008. Phase II inawonanso kuphatikiza kwa glucosamine ndi chondroitin poletsa kutayika pamodzi kwa bondo. Kuphatikizidwa kwa glucosamine ndi chondroitin kunkawoneka kuti sikuli kothandiza kwambiri popewera kuwonongeka kwa mgwirizano wokhudzana ndi osteoarthritis kusiyana ndi placebo.
Phunzirani ophunzira omwe anasowa malo ochezera ochepa pazaka ziwiri anali pakati pa magulu omwe adatenga glucosamine kapena chondroitin okha. Mwinamwake, kutenga mavitamini awiriwo pamodzi kumakhudza kuyamwa, zomwe zingagwiritse ntchito kuchepa kwazowonjezereka pamene akugwiritsidwa ntchito pamodzi.
Phase III, yomwe inkawerengera zaka zinayi za deta, inavumbulutsa kuti zowonjezereka zowonjezera kapena zokha zinalibe phindu lopweteka kwa bondo kusiyana ndi celecoxib kapena placebo. Zotsatirazo zinafalitsidwa mu 2010 mu nyuzipepala ya Annals ya Rheumatic Disease .
Malangizo a Glucosamine
- Musanayese glucosamine / chondroitin mukambirane ndi dokotala wanu ndipo mufunseni momwe zingakhalire ndi dongosolo lanu la mankhwala.
- Khalani pa mankhwala anu oyenera. Mavitamini sali m'malo mwa mankhwala omwe mwawapatsa.
- Phunzirani za glucosamine podzifufuza nokha. Pezani magwero achidziwitso omwe ali odalirika.
- Tsatirani njira zomwe zanenedwa ndi wopanga mankhwala owonjezera kapena funsani dokotala za mlingo woyenera.
- Pewani kuphatikiza zoonjezera zina.
- Gulani kuchokera kwa wopanga ulemu wotchuka. Dziwani zomwe mukupeza.
Mfundo Yofunika Kwambiri
Mu 2012, The American College of Rheumatology inafalitsa mankhwala othandizira osteoarthritis. Muzitsogozo, chondroitin kapena glucosamine sanalimbikitsidwe kuti athe kuchiritsidwa koyamba kwa osteoarthritis. Chondroitin ndi glucosamine zowonjezerapo zokha zokha kapena kuphatikiza sizingakhale zothandiza kwa odwala onse. Ikhoza kugwira ntchito kwa odwala ena, ndipo ngati ikukuthandizani, pitirizani kuchiza - ikuwoneka kuti ndi yotetezeka.
Zotsatira:
Zotsatira za glucosamine ndi / kapena chondroitin sulphate pa mapeto a knee osteoarthritis: lipoti lochokera ku glucosamine / chondroitin nyamakazi yolowera matenda. Sawitzke et al. Arthritis & Rheumatism. 2008 Oct; 58 (10): 3183-91.
http://www.ncbi.nlm.nih.gov/pubmed/18821708
Glucosamine / Chondroitin Matenda a Matenda a Nyamakazi (GAIT). NIH. Kusinthidwa kwa January 2012.
https://nccih.nih.gov/research/results/gait
Kugwiritsa ntchito kachipatala ndi chitetezo cha glucosamine, chondroitin sulphate, kuphatikiza, celecoxib kapena placebo kutengedwa kuti athetse matenda osteoarthritis a bondo: zotsatira za zaka 2 kuchokera ku GAIT. June 2010. Annals wa Rheumatic Disease. 2010; 69: 1459-1464
http://ard.bmj.com/content/69/8/1459.abstract?sid=fc95aeb7-1d79-4a79-9dac-c65916ca2125
Malangizo Othandizira Kugwiritsa Ntchito Mankhwala Osapatsirana Achipatala ndi a Pharmacologic ku Osteoarthritis a Hand, Hip, ndi Knee.Amerika College of Rheumatology 2012. (Arthritis Care & Research Vol. 64, No. 4, April 2012, masamba 465-474.)