MTHFR Gene ndi TRPV1 Gene yomwe imapereka ku Migraines
Ngati mukuvutika ndi kulepheretsa migraines, muli ndi mwayi woti mlongo wanu, msuweni wanu, kapena amayi anu azichita chimodzimodzi. Izi ndi chifukwa chakuti majini anu amakupangitsani kuti musamapangitse migraines.
Tiyeni tifufuze za genetic za migraines ndi zomwe izi zikutanthauza kwa inu ndi banja lanu.
Kuyanjana pakati pa Genesis ndi Environmental mu Mutu
Ammutu ambiri amayamba chifukwa cha ma genetiki ambiri komanso zachilengedwe zomwe zimagwirizanitsa pa intaneti.
Ambiri mwa inu mukugwira ntchito mwakhama kuti muzitha kulamulira zochitika zachilengedwe kudzera mu kutetezedwa koyamba ndi kusintha kwa khalidwe, mwachiwonekere simungasinthe majini omwe munabadwa nawo. Komabe, pogwiritsa ntchito ma genetics omwe amapezeka mu migraine, asayansi angathe kupanga mankhwala atsopano omwe amawongolera ma genees, mwachiyembekezo chochiritsa, osati kuchepetsa mutu wathu wolemetsa ndi wolepheretsa.
Mitundu Yachibadwa Yotani Imakhudzidwa ndi Migraines?
Pali udindo wapadera wokhala ndi cholowa mwachitukuko cha migraines ndi mutu wina wamutu . Izi zasonyezedwa kupyolera mu maphunziro ambiri a mabanja ndi mapasa. Koma kodi majini enieni akuperekedwa? M'munsimu muli zitsanzo za majini awiri omwe amaganiza kuti zimathandiza kupanga mapangidwe a migraines.
Jini imodzi imatchedwa Genetic MTHFR , yomwe imayimira nthawi yaitali, methylenetetrahydrofolate reductase. Izi zimaphatikizapo njira ya homocysteine. Homocysteine ndi amino acid m'magazi athu kuti pamene atakwezeka, angapangitse kuti magazi azitentha, komanso kuwombera maselo ena a mitsempha omwe angakhale ndi mutu.
Zosinthika zina mwa jinizi zakhudzana ndi migraines komanso mutu wa masana .
Kafukufuku wina mu Pharmacogenetics ndi Genomics anapeza kuti amayi omwe ali ndi migraine ndi aura , vitamini supplementation kwambiri adatsitsa mavoti awo a homocysteine, kuchepa kwa migraine, ndi migwirizano yolemala, poyerekezera ndi amayi omwe anatenga placebo.
Vitamini supplementation yachitidwa ndi vitamini B6, B9 (folic acid), ndi B12, zomwe zapezedwa kuti zichepe m'magulu a homocysteine.
Kuonjezera apo, pamene gulu la mavitamini linkayang'anitsidwa mosamala, linapezedwa kuti odwala omwe ali ndi vuto linalake la mankhwala a MTHFR anali ndi kuchepa kwakukulu m'magulu a homocysteine, komanso kuchepa kwa migraine ndi zilema, kusiyana ndi omwe ali ndi vuto losiyana . Njira ina ya jini yomwe ili ndi malo enaake pa chromosome yeniyeni. Izi zikuwonetsa kuti mitundu yambiri ya majini ingakhudze momwe anthu ogwira ntchito m'magulu amathandizira vitamini supplementation.
TRPV1 (Zomwe Zimagwirizanitsa Zomwe Zingatheke Kutengera Vutoli 1) zakhala zikulimbikitsidwa kugwira ntchito yolimbikitsana ndi migraine - mawu omwe amatanthauza dongosolo lamanjenje lopweteka kwambiri kapena lopanda mphamvu kwa odwala omwe ali ndi migraines.
Jini imeneyi yathandiza migraine hyperalgesia ndi allodynia , zinthu ziwiri zomwe zimachitika panthawi ya migraine. Hyperalgesia imatanthawuza kuwonjezereka kuchitapo kanthu pa zovuta zopweteka. Allodynia ndikumva kupweteka kopweteka kosavulaza, monga kumverera kosavuta ndi kuthandizidwa mosavuta panthawi ya kugwidwa kwa migraine.
Kwa zaka zingapo zapitazo, mankhwala okhudzana ndi njira za TRP akhala akuphunziridwa ngati njira zothandizira anthu odwala matenda a migraine.
Chitsanzo chimodzi cha mankhwala omwe amatsata njira ya TRPV1 ndi sumatriptan , yomwe imagwiritsidwa ntchito mofanana ndi migraine.
Kodi Zimenezi Zikutanthauza Chiyani kwa Ine?
Chithunzi chachikulu apa ndi chakuti migraines ali ndi mphamvu zowonongeka. Mwa kuphunzira zambiri za majeremusi omwe amachititsa kuti munthu asagwire ntchito, asayansi amatha kugwiritsira ntchito mankhwala kwa majini awa.
Komanso, kumvetsetsa chibadwa cha migraine kungathandize kuthetsa mavuto ena omwe anthu akukumana nawo, pamene amayesa kuthetsa vuto la migraine. Taganizirani kukambirana mbiri ya banja lanu ndi wothandizira zaumoyo wanu, popeza izi zingapangitse kuzindikira za migraines zanu ndikuthandizani chithandizo chamtsogolo.
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