Kodi Mavitamini a Nitric Akutsatira Mavutowa?
Akatswiri ena amanena kuti matenda otupa aakulu (CFS kapena ME / CFS ) ndi fibromyalgia (FMS) angakhale ndi chifukwa chofanana. Wofufuza wina akuti chifukwa chake ndi nitric oxide ndipo amachititsanso multiple chemical sensitivity (MCS) ndi post-traumatic stress disorder (PTSD).
Martin Pall, PHD, ndi pulofesa wa tizilombo toyambitsa matenda ku Washington State University ndipo anayamba kuyang'ana mu ME / CFS atapezeka kuti ali nawo.
Chofunika kwambiri cha lingaliro lake ndi chakuti masautso afupikitsa amachititsa kuti mchere wa nitric umangidwe mwachibadwa, umene umayambitsa kuzungulira koopsa ndipo umatsogolera ku matenda a nthawi yaitali.
Ndikofunika kukumbukira kuti pulogalamuyi ikuyesera ndipo sikutsimikiziridwa mwasayansi. Komabe, kafukufuku wochulukirapo, amachirikiza chiphunzitso cha njira zosakanikirana zowonjezereka, ndipo anthu ena amene ayesa pulotiti akunena kuti yawathandiza.
Zomwe zili pano sizikuthandizira kapena kutsutsa lingaliro la Pall koma ali pano kuti akudziwitse za zida zomwe zilipo ndi ndondomeko zamankhwala kuti muthe kusankha zochita mwanzeru. Ndikofunika kuti adziwe dokotala wanu posankha chithandizo ndikuwonekerani kuti musinthe kusintha kwa thanzi lanu.
Mavitamini a Nitric M'thupi Lanu
Nitric oxide (NO) ili m'kati mwa thupi lanu ndipo imasewera maudindo ofunika kwambiri monga kukopa kayendedwe ka oksijeni kumatenda anu ndi kutulutsa maganizo a mitsempha.
Mpaka kumapeto kwa zaka za m'ma 1990, komabe, ankaonedwa kuti ndi poizoni ndipo Pall amaona kuti ndi poizoni m'nthano yake. Kafukufuku wambiri amasonyeza kusintha kwa machitidwe akuluakulu amanjenje a anthu omwe ali ndi FMS ndi ME / CFS, ndipo Pall akuti kusintha kumeneku kungafunike kuchuluka kwa NO.
Pall imanena kuti palibe zigawo za pakatikati zamanjenje, zomwe zimayambitsa peroxynitrite, zomwe zimayambitsa minofu.
Kodi mumapeza bwanji thupi lanu LOPOSA? Pall imatulutsa 12 zovuta zowonjezereka, 8 zomwe zimayambitsa kuwonjezereka, 4 zomwe zimatsogolereka. Otsindika mwachindunji ndi awa:
- Matenda a kachilombo (ME / CFS, FMS)
- Matenda a bakiteriya (ME / CFS, FMS)
- Kusokonezeka kwa thupi (ME / CFS, FMS, PTSD)
- Kutentha kwa mpweya wa monoxide (ME / CFS)
- Kutuluka kwa tizilombo toyambitsa matenda (Organophosphorus pesticide exposure) (ME / CFS, MCS)
- Matenda a toxoplasmosis (ME / CFS)
- Maselo osakanikirana omwe amatha kusungunuka (MCS)
- Matenda osokoneza bongo (yachiwiri FMS)
Zina zowonjezera 4 zimayambitsa yankho lomwe limayambitsa ntchito yowonjezera ya NMDA, yomwe imadziwika kuti iwonjezere zigawo za NO ndi peroxynitrite (ONOO-). (NMDA receptors amatumizira chizindikiro mu ubongo ndipo mwina angachite nawo maselo osokoneza bongo.) Osautsa awa ndi awa:
- Kusokonezeka maganizo maganizo (FMS, PTSD)
- Kuchuluka kwa ciguatoxin (kuchokera ku nsomba) (ME / CFS)
- Mankhwala ophera tizilombo toyambitsa matenda (MCS)
- Pyrethroid pesticides (MCS)
Zindikirani: Palibe ziwerengero zomwe zimawonjezeka chifukwa cha zinthu zabwino, monga pamene mukuchita masewera olimbitsa thupi, kudya zakudya zochepa, kupatsa thanzi lanu kapena kusiya kusuta fodya, zomwe akatswiri amalingalira phindu kwa anthu omwe ali ndi FMS ndi ME / CFS. Ofufuza ambiri amaona kuti palibe njira zomwe zingakhale zabwino pa thanzi lanu.
Mtsinje Woipa
Pall amanena kuti kamodzi kudandaula kumayambitsa kukhazikitsa kwa NO, kumayambitsa njira yowopsya yomwe ili ndi malingaliro ambiri odzipangira.
Kuchokera kumeneko, zimakhala zovuta kwambiri komanso zovuta kumvetsa pokhapokha mutadziwa bwino za biochemistry. Ngati muli, Pall ali ndi chithunzi chonse pa webusaiti yake. Kwa ife tonse, apa pali chitsanzo cha momwe ingwe imodzi yokha yazigawo zisanu ikugwirira ntchito:
- Pamwamba PASO mlingo umawonjezera msinkhu wa peroxynitrite;
- Kuwonjezeka kwa peroxynitrite kumayambitsa kupweteka kwa okosijeni (kumangapo ma molekyulu omwe amawononga maselo. Maphunziro akugwirizanitsa kupsinjika maganizo kwa ME / CFS);
- Matenda okhudzana ndi oxidative amachititsa kuti NF-kB (yomwe imayang'anira majeremusi okhudzana ndi majeremusi ndi magetsi);
- NF-kB imapanga kuchulukitsa kwa enzyme iNOS (inducible nitric oxide synthase);
- NOS imapanga palibe msinkhu, ndipo ife tikubwerera ku sitepe imodzi.
Pall adatchula njira yoipa yomwe NO / ONOO -zungulira (yotchulidwa "ayi, o ayi!"). Akuti izi zimachitika pamtunda, chifukwa chake minofu imodzi ikhoza kupwetekedwa pamene ena omwe ali pafupi ndibwino. Limafotokozanso chifukwa chake zizindikiro zimasiyana kwambiri kuchokera kwa munthu wina.
Zizindikiro Zagawidwa
Pall amati zinthu za NO / ONOO -zungulira zingathe kufotokoza zizindikiro zambiri zomwe zilipo ndi CFS, FMS, MCS ndi PTSD. (Iye amawapereka ngati zifukwa zomveka , osati zotsimikiziridwa.) Zizindikiro izi zikuphatikizapo:
- Kuphunzira ndi kukumbukira kukumbukira,
- Kutopa ndi kugona tulo,
- Kupwetekedwa kosautsa,
- Kusokonezeka maganizo ndi nkhawa / mantha,
- Kulephera kuteteza thupi,
- Matenda owopsa a m'mimba,
- Mliri wa zakudya,
- Kusagwirizana kwa Orthostatic / hypotension (kugwidwa ndi kuthamanga kwa magazi pamene kuima kumakupangitsani kukhala wamisala.)
Kuthetsa Zopitirira
Kuti athetse pulogalamuyo, Pall akuti ayenera kukhala "pansi," zomwe zimatanthauza kuchepetsa ndi kuthetsa zinthu zomwe zimayambitsa. Mwachitsanzo, ngati kupsinjika maganizo kumachititsa kuti mukhale woipitsitsa, ayenera kuchepetsedwa kapena kuyendetsedwa. Kupitirira apo, amakhulupirira kuti zovuta zowonjezera zimafuna mitundu yambiri ya chithandizo.
Pepala la Pall pa NO / ONOO- limafotokoza zinthu zambiri - zambiri mwazopatsa zakudya zowonjezera - kuti iye akulosera kuti zidzasintha kayendetsedwe kake. (Kumbukirani kuti chiphunzitso ichi sichinatetezedwe ndipo othandizidwawo sagwiritsidwa ntchito pochiza matendawa.) Amatchulanso mankhwala omwe amagwiritsidwa ntchito ndi madokotala asanu omwe apeza bwino kuthana ndi vuto limodzi kapena angapo ndipo akuti mankhwala onsewo angakhale otsika yongolerani kayendetsedwe kake. Monga momwe mungasankhire mankhwala onse, muyenera kulankhula ndi dokotala wanu za zomwe zili zoyenera kwa inu.
Pall siyo yokhayo yomwe ikuwonetsa nitric okusayidi ngati chifukwa chothetsera matendawa. Akatswiri ambiri ofufuza kafukufuku amene akuyesa ntchito ya NO, makamaka mu fibromyalgia, akuyesa kufufuza ngati mankhwala ophera tizilombo toyambitsa matenda ndi othandiza.
Kafukufuku
Kuyambira mu 2007, buku la Pall lofotokoza chiphunzitso chake linatuluka mu 2007, kufufuza kwakukulu kwachitidwa pa ntchito ya nitric oxide muzinthu izi.
Mu ME / CFS, maphunziro angapo (Sachdeva, Kumar, Gupta) aoneka kuti akuthandizira chiphunzitsocho, mosasintha.
Maphunziro ena aumunthu amachititsanso kukopa, kuphatikizapo maphunziro a 2010 (Suarez) omwe amasonyeza kuti palibe amtabolite osadziwika atatha kuchita masewera mu ME / CFS. Kafukufuku wofalitsidwa mu 2014 (Morris) akuwonetsa kuti vuto la oxidative ndi nitrosative lingayendetse njira zowonongeka komanso zozizira zomwe zimayambitsa njira za matenda.
Komabe, phunziro limodzi (Meeus) silinapeze kugwirizana pakati pa kuchuluka kwa NO mwa magazi ndi ntchito mu ME / CFS.
Kafukufuku wochuluka (Cimen, Fatima, Sendur) amathandizanso chiphunzitso cha nitric okusakanikirana mu FMS. Wina (Kim) sanapeze kusiyana kwakukulu m'magulu ena pakati pa gulu la FMS ndi kulamulira bwino.
Kodi Pall Protocol Ndi Yoyenera Kwambiri?
Ndiwe nokha amene mungasankhe chithandizo chomwe chili choyenera kwa inu, ndipo muyenera kutsimikiza kuti mungakambirane zomwe mungachite ndi dokotala wanu. Kuphatikiza pa mbali zambiri za lamuloli zomwe zimafuna kuti dokotala azitengapo gawo, muyenera kuyang'anitsitsa kuti chithandizochi chisakhale ndi zotsatira zowononga thanzi lanu.
Zotsatira:
Cimen OB, ndi al. Mankhwala owawa. 2009 Jul-Aug; 10 (5): 813-8. Arginase, ntchito za NOS, ndi odwala omwe ali ndi matenda a fibromyalgia.
Fatima G, Das SK, Mahdi AA. Zolemba zachipatala ndi zoyesera. 2013 Nov-Dec; 31 (6 Suppl 79): S128-33. Kupanikizika kwa oxidative ndi antioxidative magawo ndi zitsulo zamtundu zili ndi odwala omwe ali ndi matenda a fibromyalgia: zomwe zimakhudza matendawa.
Gupta A, Vij G, Chopra K. Journal of neuroimmunology. 2010 Sep 14; 226 (1-2): 3-7. Ntchito yothetsera vutoli yodetsa nkhaŵa komanso kuteteza thupi laumunthu muchithunzi cha nthendayi ya matenda otopa kwambiri ndipo amachititsa kuti mchere uzitulutsa.
Kim SK, et al. Zolemba zachipatala ndi zoyesera. 2010 Nov-Dec; 28 (6 Suppl 63): S71-7. Kuuma kwa ubongo ndi mankhwala osokoneza bongo a cytokines mu matenda a fibromyalgia.
Kumar A, et al. Magazini a ku Indian of pharmacology. 2011 May; 43 (3): 324-9. Mankhwala otchedwa nitricide modulation amachititsa kuti anthu azivutika maganizo chifukwa chodwala matenda osokoneza bongo m'magulu.
Martin L. Pall, Sukulu ya Molecular Biosciences, Washington State University. Maumwini onse ndi otetezedwa. "Matenda Achilendo Paradigm Amapereka Mafotokozedwe a Gulu Lonse la Matenda."
Meeus M, et al. Mu vivo. 2010 Nov-Dec; 24 (6): 865-9. Matenda a nitric oxide ndi achilendo komanso osagwirizana ndi chiwerengero chazochitika m'thupi lakutopa.
Morris G, Maes M. Tsopano neuropharmacology. 2014 Mar 12 (2): 168-85. Matenda okhudzana ndi oxidative komanso nitrosative ndi njira zoteteza thupi kuteteza thupi lawo m'mthupi mwa odwala omwe ali ndi myalgic encephalomyelitis (ME) / matenda otupa matenda (CFS).
Sachdeva AK, Kuhad A, Chopra K. Brain. 2011 Oct 10; 86 (3-4): 165-72. Epigallocatechin ndondomeko imalimbikitsa kuchepa kwa khalidwe ndi zamoyo zamakono mu nkhono za matenda osokoneza maganizo omwe amachititsa kuti munthu asatope.
Sendur AL, ndi al. Rheumatology padziko lonse. 2009 Apr; 29 (6): 629-33. Seramu antioxidants ndi nitric okusayidi m'magetsi a fibromyalgia: kuphunzira mosamalitsa.
Suarez A, et al. Journal za thanzi la amayi. 2010 Jun; 19 (6): 1073-7. Mavitamini a nititayidi omwe amapanga masewera olimbitsa thupi pochita masewera olimbitsa thupi m'thupi.