Zimene Tikudziwa Zokhudza Izo
Mukumva kuti matenda otupa ( ME / CFS ) ndi "matenda osamvetsetseka," koma chikhalidwe ndi njira za matendawa zikuyamba kuchitika, chifukwa cha khama lomwe ochita kafukufuku akupitiriza. Kwa zaka zambiri, makamaka posachedwapa, taphunzira ndalama zambiri. Zina mwazomwe amadziwazi zimasonyeza maudindo omwe kutupa ndi kugwiritsira ntchito magalimoto kungasewere.
Kuti mumvetsetse kafukufuku, zimathandiza kudziwa pang'ono za njira zokhazokha.
Kutupa: Zothandiza & Zowononga
Tonsefe timadziwa kuti kutupa kumakhudza matenda ambiri ndi kuvulala, ndipo ndizosavuta kupeza nyumba yomwe ilibe mankhwala amodzi otsutsa-kutupa . Timaundana ndikukweza kuvulala kwathu, kuti asawonongeke kwambiri.
Komabe, zingadabwe kuti mudziwe kuti kutupa ndi mbali ya kuyankhidwa kwabwino kwa mavuto m'thupi. Pamene dongosolo lanu likumana ndi vuto-kaya liri kachilombo koyambitsa kapena mabakiteriya, kapena matenda omwe awonongeka ku chovulaza-amachititsa kutulutsa kotupa.
Chimene chimachitika ndi chakuti mitsempha ya mthupi imathamanga kuti imve magazi ochulukirapo m'derali, ndipo mapuloteni owonjezera amaponyedwa mu magazi amenewo. Maselo oyera amachoka ku mitsempha ya m'magazi kupita kumadera ovuta ndikupha kapena kuyeretsa chilichonse chimene sichiyenera kukhalapo. Ndiye minofu ikhoza kuyamba kuchiza.
Kotero pamene iwe umasintha fini lako kapena kupotoza bondo, kutupa pang'ono ndi chinthu chabwino.
Zimatanthawuza kuti machiritso akugwira ntchito.
Kumbali inayi, pamene kutupa kumakhala koopsa chifukwa cha kuwonongeka kwina kapena chitetezo cha mthupi, ndiye kuti muli ndi vuto.
Chitsanzo cha kuwonongeka kosalekeza kungakhale chinthu chofanana ndi kupweteka kwapweteka kwa kuvulazidwa komwe kumawonjezereka chifukwa chosowa, kapena kuwonongeka mobwerezabwereza chifukwa cha matenda.
Chitetezo cha chitetezo champhamvu chingatanthauze autoimmunity.
Kukhazikitsa Magetsi: Njira Yopweteka
Pachimake, thupi likuvutika ndi moto wowonjezera. Matenda a chitetezo cha mthupi apita haywire ndipo tsopano akudziwitsani gawo la thupi lanu ngati othawira kudziko lina. Icho chimayambitsa ndondomeko yotupa ndi kutumiza maselo apadera kuti awononge cholinga chake ndikuyamba machiritso.
Pokhapokha, machiritso amapanga zambiri zomwe thupi lanu silikuzikonda, choncho njirayi imapitirira mpaka kalekale.
Ndikofunika kuzindikira kuti sikuti magetsi onse a chitetezo cha chitetezo amadzimangirira.
ME / CFS: Kodi Timadziwa Chiyani?
Kwa nthawi yaitali ochita kafukufuku anandiuza kuti ME / CFS imakhala ndi kutupa kwanthawi yaitali. Kafukufuku amasonyeza kuti anthu ambiri amatha kutupa komanso amakhala ndi chitetezo champhamvu cha m'magazi m'magazi a odwala a ME / CFS. Ofufuza ena tsopano akuganiza kuti ME / CFS ndi matenda omwe amachititsa munthu kukhala ndi matenda osokoneza bongo.
Komabe, tikuphunziranso za udindo weniweni wa kutupa mthupi. Kafukufuku wam'tsogolo akuwonetsa chithunzi chowonjezereka cha kudzimangirira komweko. Ndipo pamene kuyendetsa galimoto kumakhudzidwa, funso lalikulu ndilo: kodi cholinga chake ndi chiyani?
Zifukwa Zowonjezera Zokwiya
Ambiri mwa bungwe lofufuza za ME / CFS amatenga kutukumula monga kupatsidwa. Mu dzina linalake lakuti myalgic encephalitis (ME), lomwe lavomerezedwa ndi ochita kafukufuku ena, encephalitis amatanthauza kutupa kwa ubongo ndi msana.
Ochita kafukufuku ena amanena za zovuta zomwe zimapangitsa kuti munthu asawonongeke.
Phunziro la 2012 lomwe likuyesera kuthetsa kutopa kwachilendo, matenda otopa, ndi myalgic encephalitis m'magulu osiyanasiyana. Odwala a ME anali ndi miyeso yambiri yotchedwa cytokines interleukin-1 komanso tumor necrosis factor alpha komanso neopterin. mankhwala opatsirana amphamvu kwambiri.
Posachedwapa, kafukufuku wasonyeza kuti zizindikiro zotupa zimatha kusiyanitsa molondola chikhalidwe cha kuvutika maganizo kapena makhalidwe odwala.
Kafukufuku wofalitsidwa mu Matenda a Ubongo wa Mitsempha ndi imodzi mwa thupi lomwe likukula poganizira za oxidative ndi nitrosative stress (O & NS) kuphatikizapo ma antioxidant levels omwe angatheke njira ya ME / CFS, kunena kuti izi zikhoza kuwonetsa matenda opatsirana thupi.
(Phunzirani zambiri za chiphunzitso ichi: Kupanikizika Kwambiri ndi Pall Protocol .)
Ofufuza ena asonyeza kuti tizilombo tina ta tizilombo toyambitsa matenda tingathe kuyambitsa matenda oteteza thupi kuthupi, omwe angapangitse kutupa kosaneneka ndi mavuto ambiri. Chimodzi mwa zifukwa zazikuluzikulu zomwe zimakayikira pazochitikazi ndi kachilombo ka Epstein-Barr , komwe kamayambitsa mononucleosis ("matenda opsompsona.")
Kafukufuku wina wafukufuku wa 2013 wa ma retrovirus m'matumbo amakhulupirira kuti, pogwiritsa ntchito ubongo, kugwidwa ndi ubongo kungayambitse ubongo. Ochita kafukufuku adapeza umboni wina, koma izi zinali zochepa, zophunzira zoyambirira ndipo ntchito zambiri ziyenera kuchitika m'dera lino.
Mlandu wa Kukhazikitsa Magalimoto
Ofufuza ena apeza umboni wakuti ME / CFS ndi mbali ina, matenda omwe amadziwika nawo. Zolinga zingapo zosiyana za ma chitetezo cha chitetezo cha mthupi zakhala zikuperekedwa.
Mu phunziro la 2013 lomwe likufufuza momwe mungagwirizane ndi O & NS ndi kuyendetsa galimoto, akatswiri ofufuza adanena kuti kukhalapo kwa zotupa zotchedwa cytokines ndi zina zotero zomwe zimayambitsidwa ndi ME / CFS zikhoza kukupangitsani kuti musamadzimvere. Izi zikutanthauza kuti ntchito yowonongeka ingakhale zotsatira za chikhalidwe osati chifukwa chake. Ofufuzirawa akuganiza kuti matenda opatsirana nthawi zonse angayambitse njira zingapo zomwe zingayambitse kudziimira: kuyimika kwa maselo ndi maselo ofanana.
Mu maselo ofanana ndi maselo, chitetezo cha mthupi chimalimbana ndi wodwalayo ndipo chimayamba kusokoneza ndi selo lofanana ndilo m'thupi kotero limayamba kulimbana nalo. Chofunika kwambiri, chifukwa maselo onsewo amawoneka ngati bakha, mawonekedwe a chitetezo cha mthupi amawatcha iwo abakha onse, pamene kwenikweni ali ndi tsekwe, ndipo tsekwe ndizo zamoyo.
Poyang'anira, thupi limayambitsidwa ndi kachilombo ka HIV, chitetezo cha mthupi chimayankha mwa kuyambitsa maselo apadera, ndipo, chifukwa cha zifukwa zina, kupangitsa molakwa kumayambitsa mtundu wina wa apadera-selo lokhalokha-lomwe limayambitsa zida za thupi.
Phunziro lomwelo, ochita kafukufuku amalembanso njira zina zingapo zomwe ME / CFS ingayambitse autoimmunity, kuphatikizapo kuchepa kwa mitochondria, zomwe zimapereka mphamvu kwa maselo, komanso kuwonongeka kwa ma cell chifukwa cha O & NS zomwe zimapangitsa chitetezo cha mthupi kuti chisadziwitse.
Kafukufuku wosiyana wa 2013 omwe amachitira kafukufuku omwewo amachititsa kuti pakhale njira yokha ya 5-HT, yomwe imatchedwanso Serotonin . Monga hormone ndi neurotransmitter, serotonin imapanga maudindo angapo ofunika m'matumbo ndi ubongo. Kuyambira kale, Serotonin matendawa akugwiritsidwa ntchito mu ME / CFS.
Ochita kafukufuku akunena kuti oposa 60 peresenti ya ophunzira omwe ali ndi ME / CFS anayezetsa ntchito zokhazokha zokhudzana ndi 5-HT-zochuluka kuposa nthawi 10 zomwe zimachitika pa gulu lolamulira, ndipo anayi ndi anayi omwe ali ndi kutopa kosatha khalani ndi mayankho a ME / CFS.
Kodi Mayankho Angapo Angakhale Olungama?
Pamapeto pake, zikhoza kukhala kuti mchitidwe wosiyana wa ME / CFS uli ndi zifukwa zosiyana za kutupa, ndipo zina zimakhala zosasintha pamene ena sali. Kumbukirani kuti ME / CFS ikhoza kukhala yosiyana kwambiri ndi munthu mmodzi. Zingakhale kuti magulu angapo osiyana, ndipo mwinamwake ndi matenda osiyana, pakalipano amavomerezedwa mudengu limodzi.
Asayansi akuyesetsabe kuthetsa zonsezo. Panthawiyi, muyenera kupeza njira zothetsera vuto lanu. Ndikofunika kuti mugwire ntchito ndi dokotala wanu kuti mudziwe momwe mungakhalire ndi ME / CFS ndi momwe mungachitire.
Zotsatira:
Agliari E, et al. Journal of biological dynamics. 2012; 6 (2): 740-62. Kodi kupitirizabe kachilombo ka Epstein-Barr kumapangitsa kuti munthu asatope matenda aakulu monga momwe Pavlov amaganizira za chitetezo cha mthupi?
Arnett SV, Clark IA. Journal of Affective Disorders. 2012 Dec 10; 141 (2-3): 130-42. Kutopa ndikutentha ndi khalidwe la matenda - zopanda mankhwala kuti apeze matenda ndi matenda a matenda aakulu.
De Meirleir KL, et al. Mu Vivo. 2013 Mar-Apr; 27 (2): 177-87. Maselo a Plasmacytoid dendritic mu duodenum a anthu omwe amapezeka ndi myalgic encephalomyelitis ndi apadera immunoreactive kwa antibodies kwa anthu otetezeka retroviral mapuloteni.
Fujinami RS, et al. Maphunziro a tizilombo toyambitsa matenda. 2006 Jan; 19 (1): 80-94. Kujambula kwa maselo, kuyimika, kapena kupatsirana kwa tizilombo: matenda ndi matenda omwe amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda.
Maes M, Ringel K, et al. Journal za matenda opweteka. 2013 Sep 5; 150 (2): 223-30. Mu myalgic encephalomyelitis / matenda otopa matenda aakulu, ntchito yowonjezereka yotsutsana ndi 5-HT imayanjanitsidwa ndi njira zowononga thupi komanso mabakiteriya translocation.
Maes M, Twisk FN, Johnson C. Kafukufuku wamaganizo. 2012 Dec 30; 200 (2-3): 754-60. Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), ndi Kutopa Kwambiri (CF) zimasiyanitsa molondola: zotsatira za njira zophunzitsira zosamaliridwa zogwiritsidwa ntchito pa dokotala ndi deta.
Maes M, Twisk FN, Ringel K. Psychotherapy ndi psychosomatics. 2012; 81 (5): 286-95. Matenda a chitetezo cha chitetezo cha chitetezo cha m'maganizo a myalgic encephalomyelitis / matenda otopa matenda ndi kupsinjika maganizo: zizindikiro zotupa zimapitirira mu myalgic encephalomyelitis / matenda osatopa matenda kusiyana ndi kuvutika maganizo.
Morris G, Anderson G, ndi al. BMC mankhwala. 2013 Mar 8; 11: 64. Ndemanga yofotokoza za kufanana ndi zosiyana pakati pa myalgic encephalomyelitis / matenda osatopa (ME / CFS) ndi khalidwe la matenda.
Morris G, Berk M, et al. Matenda a m'magazi. 2013 Sep 26. [Epub patsogolo pa kusindikiza] Udindo wovomerezeka wothandizana nawo mu myalgic encephalomyelitis / matenda osatopa matenda (ine / cfs).
Morris G, Maes M. Matenda a ubongo. 2012 Jun 21. Chitsanzo cha mthupi la Myalgic Encephalomyelitis / Chronic fatigue syndrome.