Zizindikiro Zomwe Zimayambitsa CFS
Kodi n'chiyani chimayambitsa matenda osatopa? Funso lovuta! Mosasamala kanthu kafukufuku wochuluka, akatswiri sanathe kuzilembapo pa chifukwa chimodzi. Ena amakhulupirira kuti matenda otopa ( ME / CFS ) amatha kuchoka ku zinthu zambiri zomwe zimasonkhana panthawi yoyenera. Zinthu izi zingaphatikizepo:
- Zosowa zamtundu
- Matenda a m'mitsempha ya pakati (CNS) ndi zosawonongeka za mahomoni
- HIV kapena matenda ena
- Matenda a chitetezo cha mthupi
- Zinthu zovuta
- Kuwonetsera kwa poizoni
Osati aliyense amene ali ndi ME / CFS ali ndi zinthu zonsezi zomwe zikuchitika. Zikuoneka kuti ndizophatikizapo zomwe, mwazifukwa zina, zakhala zikuyambitsa vutoli. Chifukwa chakuti zinthu zosiyana zingayambitse zizindikiro zosiyanasiyana ndi kusintha kwa thupi, akatswiri akudziwitsa magawo kapena magulu ang'onoang'ono a ME / CFS. Pomalizira, magulu ang'onoang'ono angakuthandizeni inu ndi dokotala wanu kupeza njira yabwino yothetsera.
Genetic Factors
Kafukufuku akugwirizanitsa ME / CFS ndi majeremusi okhudzana ndi hypothalamic-pituitary-adrenal (HPA) axis ndi dongosolo lachisomo lachisomo. Ma a HPA amalamulira tulo, kuyankha kupsinjika, ndi kupsinjika maganizo.
Mu kafukufuku wa 2006 wofalitsidwa mu Pharmacogenetics , ofufuza adawona DNA yomwe ikutsogolera momwe thupi lanu likuyendera pangozi, kuvulazidwa ndi kupsinjika maganizo, ndipo adapeza kusiyana kwakukulu komwe kunganenedwe ME / CFS ndi 76% molondola.
CDC inati izi ndi "umboni wovomerezeka woyamba wa chilengedwe cha matenda osatopa." Komabe, ochita kafukufuku sanazindikirepo ma genetic kapena kuona momwe kusiyana kwake kunakhudzira zizindikiro.
Kafukufuku wina amasonyeza kuti anthu ambiri omwe ali ndi ME / CFS amachititsa kuti majeremusi asamagwire ntchito, kulankhulana kwa maselo, ndi njira zomwe maselo anu amapezera mphamvu.
Zonsezi zikuwonetsa kuti anthu ena akhoza kukhala ndi ma geneti omwe amaloledwa ku ME / CFS - mwa kuyankhula kwina, iwo angapezeke ngati otsogolera okwanira akubwera palimodzi. Mwachitsanzo, ngati munthu amene akudwala matendawa ali ndi vuto linalake, ndiye kuti ali ndi kachilombo ka HIV kapena poizoni, amayamba kukhala ndi ME / CFS. Wina yemwe ali ndi mitundu yosiyanasiyana ya mabadwa, angabweretse mkhalidwe womwewo ndi bwino.
CNS & Hormones
Monga tafotokozera pamwambapa, anthu ena omwe ali ndi ME / CFS ali ndi vuto lalikulu mu HPA. Ochita kafukufuku amasangalatsidwa makamaka ndi mankhwala ndi mahomoni omwe amayendetsedwa ndi HPA axisiti:
- Neurotransmitter amasintha
Odwala matendawa ndi mankhwala omwe amalankhula mauthenga mu ubongo wanu. Kafukufuku wasonyeza kuti anthu ena omwe ali ndi ME / CFS ali ndi magawo osadziwika a odwala matenda a ubongo ( serotonin ndi dopamine ). Ochita kafukufuku akuyesetsa kufotokoza zomwe zimachitika mu ME / CFS. - Kusokonezeka kwa mahomoni
Akatswiri amadziŵa kuti maselo a cortisol amavutika kwambiri ndi odwala a ME / CFS, ndipo amakhulupirira kuti izi zingachititse kuti zikhale zovuta kuthana ndi nkhawa - kaya thupi (monga matenda kapena kuthamanga) kapena maganizo. Kusintha kwa Cortisol kumathandiza ena, koma osati onse, odwala a ME / CFS. Mu phunziro la 2008, amayi omwe ali ndi ME / CFS anali ndi ma cortisol ochepa mmawa pomwe amuna omwe ali ndi ME / CFS sanachite, zomwe zingathandize kufotokoza chifukwa chake chikhalidwechi chikufala kwambiri kwa amayi.
- Zosokonezeka za circadian nyimbo
Nthawi yanu yozungulira (mbali ya HPA axis) imayendetsa kayendetsedwe ka kugona kwanu. Umboni umasonyeza kuti mwa anthu ena omwe ali ndi ME / CFS kolokoyi imatayidwa, mwinamwake ndi zochitika zamaganizo kapena zolemetsa, ndipo thupi silingathe kuyimba nyimbo yoyenerera. Anthu omwe ali ndi vutoli amawoneka kuti amathera nthawi yochuluka mu kayendedwe kake ka msangamsanga (REM), komwe mukulota. Anthu omwe ali m'gulu lino la ME / CFS amalandira chithandizo chochuluka kuchokera ku mankhwala ogona kusiyana ndi anthu a magulu ena, malinga ndi akatswiri.
Matenda
Zizindikiro zambiri za ME / CFS zimakhala zofanana ndi za matenda a chiwindi, choncho kafukufuku wambiri wagwiritsira ntchito zokhudzana ndi chiwopsezo kapena matenda opatsirana.
Ofufuza asanthula ziphunzitso zitatu zokhudzana ndi matenda, ngakhale palibe zatsimikiziridwa:
- Kachilombo kapena mabakiteriya amachititsa thupi kuti liwononge chitetezo cha mthupi. Zowonongeka zimapangitsa kuti zizindikiro zokhudzana ndi chimfine zichitike ngakhale pambuyo poti kachilombo kapena mabakiteriya apita.
- Pambuyo pa matenda, chizoloŵezi chosachiritsika cha chitetezo cha mthupi chimayambitsa kachilombo koyambitsa matenda.
- Zomwe thupi limayendera ku matenda opatsirana amapezeka mwa anthu omwe ali ndi kachilombo ka HIV.
Ngakhale si onse omwe ali ndi ME / CFS amasonyeza zizindikiro za matenda, ambiri amachita. Pali zifukwa zingapo zomwe zimapereka umboni wakuti ena a ME / CFS amayamba chifukwa cha kachilombo ka HIV.
- Kulumikizana kwa Enterovirus
Mufukufuku wa 2007, anthu omwe ali ndi ME / CFS anali okhudzidwa kwambiri kuposa anthu odwala kuti akhale ndi umboni wa enteroviruses m'matumbo awo m'mimba. Majekesiti amachititsa matenda opatsirana m'mimba, ndipo zizindikiro za ME / CFS zimayambira matendawa. - Dulani L
Thupi lanu limagwiritsa ntchito mavitamini Rnase L kuti aphe mavairasi omwe akuyambitsa maselo anu, ndipo odwala a ME / CFS amakhala ndi ntchito yaikulu ya Rnase L. - Zowononga zachilengedwe (NK) Maselo ndi T
Maselo a NK & T m'thupi lanu amateteza maselo omwe ali ndi kachilombo ka HIV, ndipo anthu omwe ali ndi ME / CFS nthawi zambiri amakhala ndi zilembo za NK ndi T zomwe zimapangitsa kuti thupi lawo lisamagwire ntchito. - Ma antibodies
Anthu omwe ali ndi ME / CFS amakhala ndi ma antibodies apamwamba ku zamoyo zambiri zomwe zimayambitsa matenda chifukwa cha kutopa ndi zizindikiro zina za ME / CFS. Zamoyo zimenezi zimaphatikizapo zomwe zimayambitsa candida (yisiti), mtundu wake wa mtundu wa human herpesvirus (HHV-6), shuga, parvovirus, ndi Epstein-Barr . Ochita kafukufuku sanathe kusonyeza kuti chimodzi mwa izi ndi chifukwa chachikulu cha ME / CFS. - Chiyambi cha matenda
Pafupifupi 80 peresenti ya ME / CFS milandu imayamba mwadzidzidzi chikhalidwe chofanana ndi chimfine. - Kuphulika kwa magulu
Ngakhale kuti CDC sinatsimikizire kuphulika kwa masango ambiri, mauthenga a anthu angapo omwe ali m'nyumba imodzi, malo ogwira ntchito, ndi kumudzi komwe kuli ME / CFS nthawi imodzi sikumveka.
Akatswiri ena amanena kuti kusintha kwa mabakiteriya omwe alibe chiopsezo m'matumbo kungathandize kuti chitukuko cha ME / CFS chikule.
Komabe, umboni wina ukuwoneka kuti ukutsutsana ndi chidziwitso cha tizilombo. ME / CFS samaoneka ngati imafalitsidwa mwachindunji, anthu omwe ali nawo samawoneka okhudzidwa, ndipo - mosasamala za maphunziro opangidwa bwino - ochita kafukufuku sanathe kuyanjanitsa ME / CFS ndi matenda enaake.
Chidziwitso Chokhudza XMRV
Mu 2009, ofufuza a Whittemore Peterson Institute (WPI) adafalitsa kafukufuku m'nyuzipepala ya Sayansi yomwe inanena kuti kugwirizana pakati pa XMRV, retrovirus yatsopano, ndi ME / CFS. Anapeza XMRV pafupifupi 67 peresenti ya magazi kuchokera kwa odwala a ME / CFS. Awonanso kuti ndi 3% ya machitidwe abwino.
Komabe, zotsatira zopititsa patsogolo zinalephera kutsimikizira mgwirizanowu, kuphatikizapo phunziro lalikulu lomwe likuphatikiza kafukufuku wamkulu wa WPI. Maphunziro ena amapereka njira zomwe zitha kupangitsa kuti chinyengo chikhale chonchi mu phunziro lapachiyambi. Chakumapeto kwa 2011, chiphunzitso cha XMRV chinali chonse-koma chinasiyidwa.
Chitetezo chautetezo
Maphunziro angapo asonyeza zosayenerera m'thupi la anthu lomwe liri ndi ME / CFS, koma ofufuza sanapeze njira yosagwirizana. Zina mwazofala kwambiri ndi matenda a chiwopsezo komanso chitetezo cha m'thupi.
Kafukufuku wina wanena kuti ambiri a ME / CFS odwala sagwirizana ndi zinthu monga mungu, zakudya ndi zitsulo monga nickel ndi mercury.
Izi zimatsogoleredwa ku chiphunzitso chakuti zizindikiro zingayambitse zovuta zambiri zomwe zimayambitsa ME / CFS. Nthano imodzi ndi yakuti chifuwa, nkhawa ndi matenda zingathe kuphatikizapo mankhwala otchedwa adenosine triphosphate (ATP), omwe amasungira mphamvu m'maselo. Odwala ena a ME / CFS amasonyeza umboni wa kuchepa kwa ATP.
Odwala ena a ME / CFS ali ndi zinthu zambiri zotchedwa cytokines , zomwe akatswiri asayansi amatha kuchita zimayambitsa zizindikiro za ME / CFS, kuphatikizapo kutopa ndi minofu. Kafukufuku wina wanena kuti pali kusiyana kwa maselo pakati pa anthu omwe ali ndi ME / CFS, koma kafukufuku wina sanatsimikizire kuti T cell ndi cytokine sizinali zachilendo.
Matenda otha msinkhu amatha kukhala ndi zochitika zofanana ndi matenda omwe amadzimadzimadzimadzi monga lupus kapena multiple sclerosis , momwe chitetezo cha mthupi chimalowera bwino thupi. Kafukufuku wochuluka akusonyeza kuti ME / CFS ingaimire.
Kusokonezeka maganizo
Ochita kafukufuku amakhulupirira kuti malingaliro anu, umunthu ndi chikhalidwe chanu zingakhudze ngati mutakhala ndi ME / CFS, koma iwo samvetsetse bwino mgwirizano wovuta pakati pawo.
Ngakhale kuti izi sizingakhale chifukwa chachikulu cha ME / CFS, iwo angakhale nawo mbali kuti akukhudzireni.
Zindikirani: ME / CFS sichikudziwika kuti ndi matenda aakulu, komanso kukhala ndi ME / CFS kumatanthauza kuti munthu ndi wofooka kapena sangathe kupirira zinthu. Ngakhale kuti nthawi zina zimagwirizanitsidwa ndi matenda ovutika maganizo, ME / CFS ndi chikhalidwe chosiyana.
Mankhwala / Toxini
Mu gulu limodzi, kutopa ndi kupweteka kwambiri kumayanjanitsidwa ndi kuwonetsedwa kwa mankhwala osiyanasiyana ndi poizoni za chilengedwe. Izi zimaphatikizapo zotupa, mankhwala opha tizilombo kapena zitsulo. Komabe, chifukwa ambiri a ife takhala tikudziwidwa ndi mankhwalawa nthawi zina, zimakhala zovuta kufufuza zomwe zingayambitse mavuto. Matenda otchedwa multiple chemical sensitivity (MCS) amachititsa zizindikiro zambiri monga Me / CFS, ndipo ziŵirizi zikuwoneka kuti zikuphatikizana .
Zotsatira:
2006 Zokonza ndi Kupewa Matenda. "Chifukwa Chotheka"
Dr. JKS Chia. Copyright 2005 Co-Cure. Maumwini onse ndi otetezedwa. "Udindo wa enterovirus mu matenda aakulu otopa"
Kaiser J. Science. 2011 Jan 7; 331 (6013): 17. Matenda otopa nthawi zonse. Kafukufuku amasonyeza kuti zowonongeka zingapezeke pazowunikira za XMRV.
Lombardi VC, et al. Sayansi. 2009 Oct 23; 326 (5952): 585-9. Kuzindikira kwa retrovirus yotenga matenda, XMRV, m'magazi a anthu omwe ali ndi matenda osatopa
Nater UM, ndi al. Journal of clinic endocrinology ndi kagayidwe kake. 2008 Mar; 93 (3): 703-9. Amayesedwa m'mavuto a cortisol m'mawa mmawa pophunzira anthu omwe ali ndi matenda otopa komanso odwala bwino.
Simmons G, ndi. al. Sayansi. 2011 Nov 11; 334 (6057): 814-7. Kulephera kutsimikizira XMRV / MLVs m'magazi a odwala omwe ali ndi matenda olemala.
Vernon, S. Pharmacogenomics, April 2006; vol 7: pp 345-354. Vuto lophatikizira deta yosiyana-siyana: deta, matenda ndi ma laboratory omwe amasonkhanitsidwa panthawi yophunzira kuchipatala cha matenda osatopa.