Zimene Amafufuza
Amitriptyline ndi wodzitetezera wotchuka womwe umapezeka mu mawonekedwe enieni ku US Iwo ankagulitsidwa pansi pa dzina lakuti Elavil.
Amitriptyline imakhala ngati tricyclic yodetsa nkhaŵa. Kwazaka zambiri, madokotala ena aona kuti ndi mankhwala oyambirira a fibromyalgia ndi matenda otha mphamvu ( ME / CFS ). Komabe, izi zinapangidwira kwambiri kuchokera ku ntchito ya mayesero ndi zolakwika kusiyana ndi maphunziro a zachipatala.
M'zaka zaposachedwapa, makamaka pakubwera kwa mankhwala a FDA -vomerezedwa ndi fibromyalgia, kugwiritsa ntchito amitriptyline chifukwa cha matendawa adatsika. Amitriptyline akadalibe, komabe, nthawi zina amagwiritsidwa ntchito ngati mankhwala owonetsetsa mu maphunziro opanga mankhwala a fibromyalgia, ndipo madokotala ambiri amapitirizabe kutero chifukwa cha izi.
Momwe Ikugwirira Ntchito
Amitriptyline ndi mankhwala ena a tricyclic amalingalira kuti aziwonjezera kuchuluka kwa serotonin ya neurotransmitters ndi norepinephrine yomwe ubongo wanu ukhoza kugwiritsa ntchito. Amachita zimenezi mwa kuchepetseratu njira yotchedwa "reuptake," yomwe ndi pamene maselo apadera amatha kugwiritsa ntchito ma neurotransmitter kuti athe kugwiritsidwanso ntchito kwinakwake.
Mankhwala ena otetezera matenda, otchedwa reuptake inhibitors, amagwiritsa ntchito njira zosiyanasiyana kuti athandizidwe mofanana.
Serotonin ndi norepinephrine amakhulupirira kuti akuphatikizidwa mu fibromyalgia ndi ME / CFS.
Komanso Onaninso:
Fibromyalgia
Kupenda kwa 2012 kwa amitriptyline kwa fibromyalgia kunanena izi ponena za mankhwalawa mu fibromyalgia:
Amitriptyline wakhala chithandizo choyamba cha kupweteka kwa mtima kwa zaka zambiri. Mfundo yakuti palibe umboni wosathandiza wosagwirizana ndi zotsatira zake ndizokhumudwitsa, koma ziyenera kukhala zogwirizana ndi zaka zambiri zachipatala kwa odwala ambiri omwe amavutika ndi ubongo kapena fibromyalgia. (Moore, et al, pansipa.)
Kuwongolera kukupitiriza kunena kuti kuwonetsa kuti kulimbika kwake kumakhala kovuta chifukwa kafukufuku waposachedwapa amasonyeza anthu ochepa okha omwe amayesa izo adzakhala ndi mpumulo wokhutiritsa wokhutiritsa.
Kukonzanso kwina chaka chimenecho, chomwe chinaphatikizansopo kuponderezedwa kwa duloxetine ndi milnacipran, anati:
Ochepa odwala amakhala ndi mpumulo wochuluka wachisangalalo popanda ayi kapena zotsatira zochepa. Komabe, chiwerengero chochuluka cha odwala amasiya kusiya mankhwala chifukwa cha zovuta zovuta kapena zochitika zochepa chabe zotsitsimutsa zizindikiro, zomwe sizikuposa zotsatira zovuta. (Hauser, Wolfe et al, pansipa.)
Kupenda kwa 2011 (Clemons, et al, m'munsimu) akuti amitriptyline sayenera kuonedwa ngati golidi ya fibromyalgia chifukwa cha kuchepa kwa maphunziro omwe adachitidwa.
Komabe, mu 2011, kafukufuku wa mankhwala okhudza tizilombo toyambitsa matenda a fibromyalgia (Smith, et al, m'munsimu) adanena kuti amitriptyline inali yofanana ndi mankhwala a FDA omwe amavomereza - Lyrica (pregabalin), Cymbalta (duloxetine), ndi Savella (milnacipran) pamene anavutika ndi kutopa.
Madokotala ena angasankhe amitriptyline pa zifukwa zingapo:
- Mbiri yake yakale ya ntchito, ndi
- Ndalama zake zochepa zikuyerekeza ndi FDA -vomerezedwa ndi fibromyalgia mankhwala.
Mwachitsanzo, kupereka kwa mwezi umodzi wamitriptyline kumatha pakati pa $ 15 ndi $ 65, malingana ndi mlingo. Pakali pano, Cymbalta (duloxetine) ya mwezi umodzi, Lyrica (pregabalin), kapena Savella (milnacipran) imayamba pafupifupi madola 125 ndipo imatha kufika madola 180. (Izi zingasinthe ngati duloxetine ya generic imabwera pamsika.)
Matenda Osalekeza Osalekeza
Amitriptyline ali ndi mbiri yakale ya ntchito kwa ME / CFS, ngakhale kuti alibe maphunziro a zachipatala komanso chifukwa cha zochitika zenizeni za kusintha. Kafukufuku wochepa kwambiri wapangidwa.
Kufufuza kwa 2012, komabe, adawoneka amitriptyline kwa ME / CFS ndipo adapeza kuti ndiwo wokhawo mwazinthu zambiri zomwe zimayambitsa matenda oletsa kupatsirana maganizo omwe analepheretsanso kuti maselo oterewa atuluke, omwe amakhulupirira kuti amagwira ntchito mu ME / CFS.
Mlingo
Kwa akuluakulu, mlingo wa amitriptyline umatha kukhala 40 mg mpaka 150 mg patsiku. Nthawi zambiri amagawidwa muyezo waukulu.
Zitha kutenga mwezi wonse kuti muone kusintha kwa mankhwalawa.
Onetsetsani kutsatira malangizo a dokotala kuti mutenge mankhwala awa. Ngati mukufuna kusiya, musaime mwadzidzidzi. Funsani dokotala wanu za njira yoyenera yogwiritsira ntchito mankhwalawa.
Zotsatira Zotsatira
Monga momwe zimakhalira ndi matenda onse opatsirana pogonana, zimakhala ndi chenjezo powonjezera ngozi ya kudzipha kapena kuyesera kwa anthu osakwana zaka 24.
Amitriptyline ali ndi mndandanda wautali wa zotsatira zoyenera. Zotsatira zoyipa zambiri zimaphatikizapo:
- Kusakhazikika,
- Zoopsya,
- Nsowa kapena kusanza,
- Kuvuta kukodza,
- Kutsekedwa,
- Kutuluka thukuta kwambiri,
- Kusintha kwa kulemera kapena chilakolako,
- Kusintha kwa kugonana kapena kugonana,
- Ululu, kuwotchedwa kapena kukwapula m'manja kapena mapazi.
Ngati muli ndi zotsatira zoopsa zotsatirazi, muyenera kutchula dokotala mwamsanga:
- Kulankhula pang'ono, zovuta kulankhula,
- Kutaya,
- Kufooka kapena kupweteka kwa chiwalo,
- Kuswa kupweteka pachifuwa,
- Kuphatikizika kwa mtima,
- Kuthamanga kwakukulu kapena ming'oma,
- Kutupa kwa nkhope ndi lilime,
- Khungu loyera kapena maso,
- Mphuno ya minofu m'nsagwada, pakhosi ndi kumbuyo,
- Kusagwedezeka kosagwedezeka,
- Kutuluka mwachilendo kapena kuvulaza,
- Kugonjetsa,
- Hallucinations.
Chifukwa mankhwalawa akuwonjezera kuchuluka kwa serotonin, muyenera kupewa mankhwala ena omwe amachititsa kuti serotonin iwonjezeke ndikuphunzira zizindikiro za zomwe zingachititse zakupha: Serotonin Syndrome.
Mofanana ndi mankhwala alionse, ndizofunika kuti inu ndi dokotala wanu muchepetse kuopsa kwa phindu lanu ndikusankha mankhwala omwe mukuyenera.
Zotsatira:
Clemons A, et al. Journal of psychopharmacology yachipatala. 2011 Jun; 31 (3): 385-7. Amitriptyline ndi prochlorperazine inhib prolammatory mediator kumasulidwa ku maselo a anthu: zitha kukhala zofunikira kwa matenda aakulu.
Hauser W, Petzke F, et al. Rheumatology (Oxford.) 2011 Mar; 50 (3): 532-43. Kuyerekezera mphamvu ndi kuvomereza kwa amitriptyline, duloxetine ndi milnacipran mu matenda a fibromyalgia: ndondomeko yowonongeka ndi meta-analysis.
Hauser w, Wolfe F, et al. CNS mankhwala. 2012 Apr 1; 26 (4): 297-307. Udindo wodetsa nkhaŵa m'kuyang'anira matenda a fibromyalgia: ndondomeko yowonongeka ndi kusanthula meta.
Moore RA, ndi al. Msonkhano wa Cochrane wa ndemanga zowonongeka. 2012 Dec 12; 12: CD008242. Amitriptyline kuti amve kupweteka kwa mtima ndi fibromyalgia mwa akuluakulu.
Okea, dokotala wa banja la R. American. 2010 Oct 15; 82 (8): 901-904. Milnacipran (Savella) ya fibromyalgia.
Smith B, ndi al. Maphunziro a Zamankhwala. Mwezi wa 2011 Purezidenti Wotsutsa Mankhwala: Mankhwala a Fibromyalgia: Final Final Report.
US Food & Drug Administration. Amitriptyline Safety Alerts. Idapezeka mu September 2014.