Zochitika Zoipa Zokhudzana ndi Mutu wa Mutu wa Mutu kapena Mlomo Ungakuthandizeni Kusankha
Mankhwala otsutsana ndi kutupa (nonsteroidal anti-inflammatory drugs (NSAIDs) ndi amodzi mwa mankhwala otchuka kwambiri komanso omwe amalembedwa kaamba ka nyamakazi. NSAID zikhoza kutengedwa pamlomo ngati mapiritsi, capsules kapena zamadzimadzi. NSAID zimapezekanso m'mawu othandizira, monga kirimu, gel kapena madzi ogwiritsidwa ntchito khungu.
Kodi NSAID Zotchulidwa M'maganizo Zimagwira Ntchito Motani?
NSAID zamasewero, monga ibuprofen zam'mutu kapena gel Voltaren , zimagwiritsidwa ntchito khungu pamtundu wowawa.
Pali ubwino wina wokhudzana ndi NSAID zamaphunziro monga:
- Kupititsa patsogolo mankhwala osokoneza bongo
- kuchepa kwa zizoloŵezi zowonongeka monga matenda a zilonda zam'mimba ndi m'mimba mwazi
NSAID zamasewera zimadutsa pang'onopang'ono, kupereka ndalama zochepa pozungulira. Poyerekeza ndi NSAID zamlomo, mapulogalamu apamwamba amapita kumalo okwera kwambiri a NSAID m'madzi (chikopa cha khungu pansi pa epidermis chomwe chimakhala ndi minofu). Zovuta zomwe zimapezeka m'magulu a minofu pansi pa malo ogwiritsirana ntchito, koma osachepera amodzimodzi ndi zomwe zakhala zikugwiritsidwa ntchito poyendetsa mawu a NSAID.
NSAID zamasewero zimatha kufika ku synovial madzi , koma ndi njira yeniyeni yeniyeni yomwe ndi yotsimikiziranso. Kusiyanasiyana kwa munthu pa khungu kungayang'ane zosiyana siyana zomwe zimapezeka mukutenga kwa ma NSAID.
Kawirikawiri, zimakhala zovuta kudziwa ngati NSAID zapamwamba kapena zamlomo zili bwino chifukwa zawonetsedwa kuti mu mayesero a chipatala muli mlingo wokwera kwambiri wa placebo.
Anthu amafotokoza mpumulo ngakhale kuti palibe mankhwala othandizira piritsi kapena kirimu.
Kodi NALIDZI Za Mlomo Zimagwira Ntchito Motani?
Mankhwala a NSAID amamwa mankhwala, mapiritsi kapena mankhwala omwe amamwa. Amadutsa m'magazi ndipo amalowa m'magazi, omwe amakhala ndi zotsatirapo m'thupi lonse. NALIDZI zamlomo zimagwiritsira ntchito poletsa cyclooxygenase (COX) , puloteni yomwe imayambitsa arachidonic acid kwa prostaglandins ndi leukotrienes.
Arachidonic asidi amamasulidwa ku memphane phospholipids poyankha zowopsya. Prostaglandins amapanga yankho yotupa. NSAID zimadodometsa kupanga prostaglandin mwa kuletsa cyclooxygenase.
Kusiyanasiyana kwa Zochitika Zoipa Pakati pa Mlomo ndi NSAID Zambiri
NSAID zamasewera ali ndi mbiri yabwino ya chitetezo kuposa NSAID zamlomo. Zotsatira zovuta zokhudzana ndi ntchito za NSAID zamatsenga zimapezeka pafupifupi 10 mpaka 15% mwa odwala ndipo zimakhala zochepa kwambiri. Mankhwala osokoneza bongo amapezeka mosavuta ndi ma NSAID opangidwa ndi mapeyala, poyerekezera ndi chiwerengero cha 15% cha ma NSAID.
Mmene Odwala Amasankhira Pakati pa Zida za Nthendayi
Kuchokera pa mbiri ziwiri zofalitsidwa mu British Medical Journal (BMJ) , zinaonekeratu kuti chisankho chomwe chithandizo cha NSAID, pamlomo kapena pamasewero, kugwiritsira ntchito ndizochokera:
- kuleza mtima podziwa kuti chiopsezo chimakhalapo
- kukhalapo kwa matenda ena
- mlingo wa ululu
- malangizo alandiridwa
- zokhazikika (mtengo ndi mosavuta ntchito)
Mu BMJ , ochita kafukufuku anapeza kuti "NSAID zapamwamba zimakhala zotetezeka, zopanda chitetezo kumalo opatsirana a NSAID kuti azitsatira mafupa a m'magazi , ngakhale atakhala ndi malo otsekemera amafotokozera zambiri zamtengo wapatali."
Monga nthawi zonse, kambiranani ndi dokotala wanu zomwe mungasankhe ndikugwira ntchito limodzi kuti mupeze chomwe chili chabwino pa moyo wanu.
> Zotsatira:
> Mankhwala opatsirana pogwiritsa ntchito ma NSAID m'matenda a chifuwa: kuyerekezera. Mankhwala. 2000 Sep; 60 (3): 555-74. Heyneman CA ndi al.
> Makhalidwe ndi mndandanda wa NSAID wothandizira mazunzo a OA - momwe ndi chifukwa chake anthu amasankha mankhwala. December 5, 2007. > UKMiCentral >. NHS.