Melatonin wakhala akudziwika kuti ndi chithandizo cha jet ndi kugona . Dziko lachipatala lomwe likugwirizanitsa limalimbikitsa kwambiri amayi omwe ali ndi khansa ya m'mawere , komanso matenda a fibromyalgia ndi chizindikiro chotopa . Koma melatonin ikupeza chidwi kwambiri kuti ikhoza kuthandizira chithokomiro ndi mahomoni.
Melatonin ndi hormona yokha, yomwe imapangidwa ndi chinangwa cha pineal, chomwe ndi kachilombo kakang'ono kamene kali mu ubongo.
Mtundu wa pineal umatengedwa kuti ndi woyang'anira wotsogolera thupi lathu, kuphatikizapo nthawi yathu ya tsiku ndi tsiku yomwe imatiuza nthawi yoti tigone ndi nthawi yoti tidzutse, komanso nthawi yotalikirapo yomwe imatchula zochitika zazikulu zowonongeka, monga pamene ife kulowa msinkhu ndi kutha kwa kusamba .
Mtedza wa pineal umatsogolera nyimbo za circadian mwa kumasula melatonin, mahomoni opangidwa makamaka usiku. Kulumikizana kwa Melatonin ndi kumasulidwa makamaka kumayambitsidwa ndi mdima.
Pogwiritsa ntchito mbali yake yozungulira ndi kugona, melatonin yadziwika bwino ngati thandizo lothandizira kugona, monga chithandizo chothandizira kuteteza ndege ndi kubwezeretsa nthawi ya thupi nthawi yatsopano, komanso ogwira ntchito usiku omwe amavutika kugona.
Zinali ngati chithandizo chogona chimene ndinayamba kugwiritsira ntchito usiku wa melatonin pamene ndinali pa nthawi yoyamba. Ndinali ndikudzuka nthawi zambiri, ndipo nthawi zambiri sindinkagona. Kenaka, nditadzuka m'mawa, ndinamva kuti ndine wosasunthika komanso wotopa.
Ndinayamba kumwa mlingo wochepa wa melatonin (3 mg), yomwe ndinatenga nthawi ya 11 koloko masana, pafupifupi ola limodzi ndisanayambe kugona. Patapita sabata, ndinazindikira kuti ndinadzuka pang'ono, ndipo pamene ndinatero, ndinatha kutembenuka ndi kugona tulo. Ngakhale kulibwino, ndimadzuka m'mawa ndikukhala wokondwa komanso wolimbikitsidwa, mwachimwemwe.
Chodabwitsa kwambiri, ndinali kwenikweni kudzuka maminiti angapo chisanafike alamu. (Izi sizowoneka ngati khalidwe, monga momwe ine ndinalili mmodzi wa anthu omwe anagunda snooze bar mowirikiza, ndipo pokhapokha ndikudandaula ndikudzikuza ndekha pogona. Kotero kukwera pamaso pa alamu, kumverera bwino, kunali kosavuta!)
Pa nthawi yomwe ndinayambira melatonin, ndinkakhalanso bwino. Ndinali ndi nthawi yosavuta kwa zaka ziwiri, ndipo ndakhala miyezi isanu kuchokera pamene ndinayamba kusamba . Ndinkasambira panthawi yamoto otentha pogwiritsa ntchito mankhwala enaake otchedwa Royal Maca , ndipo kutentha kwakukulu kunali kutatha. Ndinawona dokotala wanga, yemwe adapeza kuti ndinali ndi mkulu wa FSH ndi LH maimidwe -omwe amatha kutseka mimba mwa mkazi amene alibe nthawi yina-ndipo ma esrogen ndi ma progesterone anali otsika. Kotero dokotala wanga ndi ine tonse tinaganiza kuti ndinali mu menopaus e-zonse zomwe ndinkafunikira kuti ndipite miyezi 12 yonse popanda nthawi, ndipo izi zikanakhala zomveka. Ndipo chomwe chinachitika kenako chinandidabwitsa.
Pafupi miyezi iwiri nditayamba melatonin, nthawi yanga inabwerera. Ndipo pamene adabwerera, anali achilendo. Iwo sanali olemetsa modabwitsa, monga analili kale. Mtunduwo unali wodabwitsa ndipo mwinamwake wodabwitsa kwambiri, iwo anayamba kubwera nthawi zonse masiku 28, omwe sanachitikepo kwa zaka zingapo.
Sindinayambe kugwirizanitsa melatonin ndi kubwerera kwa msambo wokhazikika. Koma popanda china chilichonse chinasinthidwa mu regimen yanga, ndinafunika kudzifunsa kuti ngati nthawi yeniyeni ya kumaliseche ya mzimayi / a menopausal inali yodziwika ndi zotsatira za melatonin. Ndinafufuza mufukufukuwo. Ndipo ndi pamene ine ndinamupeza Dr. Walter Pierpaoli, ndi kafukufuku wake wochititsa chidwi ndi wochititsa chidwi pa melatonin.
Melatonin ndi Hormones Yathu
Dokotala wa ku Italy dzina lake Walter Pierpaoli, MD, adabwerera m'mbuyo mu 1996 ndi kumasulidwa kwake kwa dziko lonse lapansi, Melatonin Chozizwitsa: Zaka za Chilengedwe-Kutembenuka, Kulimbana ndi Matenda, Kugonana-Kuwonjezera Hormone .
Bukuli linali lopindulitsa kwambiri, ndipo chozizwitsa cha Dr. Pierpaoli cha Melatonin chinapangitsa anthu a ku America ku melatonin, yomwe inali itangowonjezera ku United States zaka zingapo zapitazo, ndipo ntchito zake monga thandizo lagona, jet lag remedy, immune enhancer, ndi zotheka antioxidant khansa womenya nkhondo.
Koma bukuli silinali nthawi imodzi ndi Dr. Pierpaoli. Kwazaka zambiri, wakhala akufufuza ndi kuphunzira melatonin ndi zotsatira zake.
Nditawerenga buku la Dr. Pierpaoli, ndinawerenganso magazini yofufuzira imene iye anapereka, ya Annal 2005 ya The New York Academy of Sciences, yomwe imatchedwa Kutembenuka kwa Kukalamba: Kukonzanso Pineal Clock . Bukuli la Annals lili ndi zolemba zambiri zamaphunziro komanso zofukufuku zomwe zakhudzana ndi melatonin, kuphatikizapo malipoti angapo ochokera kwa Dr. Pierpaoli. Ndinalinso wokondwa kuyankhula ndi Dr. Pierpaoli mwiniwake, kuti ndiphunzire zambiri za maganizo ake ponena za melatonin ndi mahomoni a chithokomiro.
Ndaphunzira kuti ochita kafukufuku ambiri amaona kuti melatonin imakhala yovuta kwambiri kuposa kuwonongera kwa mahomoni. M'malo mwake, iwo amaona kuti melatonin imakhala mkhalapakati wamakampani omwe amagwira ntchito m'njira zomwe sitimvetsetsa, koma kuti Dr. Pierpaoli ndi ena akuphunzira kwambiri.
Zimene Dr. Pierpaoli akulongosola m'buku lake ndi kufufuza kwapeza ndizoti pinial gland imatulutsa melatonin mochepa ngati ifeyo, koma ngati mankhwala a melatonin amatengedwa pamene magulu a melatonin akuchepa, zotsatira zina za ukalamba zimatha kuchepa, kuima, kapena ngakhale, akuti Dr. Pierpaoli, anabwerera. Dr Pierpaoli akukhulupiliranso kuti melatonin ikhoza kugwirizanitsanso osati kayendedwe ka circadian kotsitsimula-kugona koma dongosolo la endocrine.
Dr. Pierpaoli akuti kupereka mavitamini a supplemental , pa mlingo wa 3 mg usiku, amalola kuti pinial gland "apumule" polankhula, ndipo amateteza matenda a pineal ku ukalamba, zomwe zimachepetsanso ukalamba wa ziwalo zina ndi ziwalo zina. Ichi ndi nthano yotsutsana, koma Dr. Pierpaoli ndi ena apanga maphunziro ochititsa chidwi omwe amasonyeza kuti ali pa chinachake.
M'malemba ake, Dr. Pierpaoli akulongosola maphunziro a nyama omwe anapeza kuti nyama zakale zochiritsidwa ndi melatonin zimabwerera kumalo othamanga tsiku lililonse la mahomoni a chithokomiro. Nkhumba zomwe zinali ndi miyezi 24 ndikuchiritsidwa ndi melatonin, miyezi 24 ndi mbewa yofanana ndi zaka 75 kwa anthu, inali ndi mazira omwe anali oposa kukula kwa mbewa zosatulutsidwa, kutanthauza ntchito yambiri yogonana. Dokotala Pierpaoli nayenso anawongolera matenda a pineal a mbewa okalamba m'magulu ang'onoang'ono, ndipo mosiyana. Nthanga zazing'ono zomwe zimakhala ndi zofiira zakale zapineal zinayambitsa matenda osiyanasiyana okhudzana ndi ukalamba, zidakhala zochepa zochepa komanso zowonjezera, ndipo zinamwalira kwambiri kuposa zachibadwa. Nkhumba zakale zomwe zimakhala ndi tizilombo ta pineal zinayambanso tsitsi, zimapeza mphamvu, zimayambitsa kugonana, ndipo zimakhala ndi moyo kwa nthawi yayitali kuti ngati zikanakhala anthu, zikanakhala zolimba, zogwira ntchito, zathanzi komanso zogonana zaka zoposa 100 wa zaka.
Koma chomwe chinandifotokozera kubwerera kwanga kozizwitsa kwa nthawi yoyamba ya msambo ndi maphunziro a ku Italy omwe adachitidwa ndi Dr. Pierpaoli omwe amayang'ana akazi omwe ali ndi zaka 42 mpaka 62, omwe amawerengera zotsatira za mlingo wa 3 mg wa melatonin pa miyezi isanu ndi umodzi. Kafukufuku ameneyu anapeza kuti melatonin inakula kwambiri ma yeserojeni ndi ntchito yowonongeka. Azimayi oposa 50 omwe amagwiritsira ntchito melatonin adachepetsanso mahomoni a Luteinizing (LH) ndi mahomoni otulutsa mpweya woipa (FSH) chifukwa cha melatonin. Ena mwa atsikana achichepere, nthawi yoyamba ya kusamba anabwezeretsedwa. Ndipo n'zosadabwitsa kuti akazi ambiri omwe kale anali am'mbuyo wam'mbuyo amatha kubwerera ku miyambo yoyamba. Kwenikweni, malinga ndi Dr. Pierpaoli ndi ochita kafukufuku anzake, mlingo wochepa wa melatonin umachedwa-kapena nthawi zina, kusintha kwake komwe kumachitika panthawi yopuma.
Pankhani ya chithokomiro, melatonin siinasinthe mazinga a TSH koma idathandiza kusintha kutembenuka kwa T4 kufika ku T3 , zomwe zinachititsa kuti ma T3 awonjezeke mu gulu lophunzira.
Akazi okwana 96 peresenti mu phunziro lomwe adatenga melatonin amanenanso kupezeka kwa kusokonezeka kwa m'mawa kwathunthu, chizindikiro chomwe chimakhala chachizoloŵezi kwa amayi a perimenopausal ndi a menopausal . Azimayiwa anali ndi madandaulo ochepa okhudza kutentha, kuchepa kwa mtima, komanso ubwino wokhala ndi tulo.
Ngakhale kuti izi sizinali zophunzira zazikulu, zinagwiritsidwa ntchito mwakhama, ndipo zimasonyeza kuti melatonin ingakhale ndi gawo lofunika kwambiri mu malamulo a mahomoni kwa amayi omwe ali ndi vuto la amayi, komanso makamaka kwa omwe ali ndi kusamvana kwa chithokomiro.
Dr. Pierpaoli akuwona kuti kugwa kwa melatonin yomwe imachitika muzaka makumi anai zazimayi kungakhale chizindikiro cha hormonal chomwe chimauza thupi kuti liyambe kusinthika kwa chiwonetsero. Tikudziwa kuti akazi kuyambira 40 mpaka 44, melatonin imatha kuchepa kwambiri. Chochititsa chidwi, ichi ndicho mfundo yomwe nthawi zambiri imayamba kuyambira. Mfundo yaikulu yotsatira ya kuchepa kwa melatonin imatenga zaka 50 mpaka 54, pafupi ndi nthawi yomwe nthawi ya kusamba imasiya ubwino kwa amai ambiri.
Nthano yochititsa chidwi ya Dr. Pierpaoli inapeza chithandizo ndi zomwe zinafukufuku wafukufuku wa 2008 womwe unalembedwa m'nyuzipepala ya Menopause. Kafukufukuyo anapeza kuti pineal gland, kudzera mu melatonin, imakhudzidwa ndi njira zomwe zimayambitsa kusamba kwa thupi, ndipo pokhala ndi makina apamwamba a melatonin, kuyamba kwa kusamba kumatha kuchedwa.
Dr. Pierpaoli ndi, popanda funso, woimira mwakhama pa melatonin. Dokotala mwiniwakeyo ndi chithunzi chabwino cha njira yake yotsutsa ukalamba, oposa 80, olimbikira, ndikusunga ndondomeko yovuta ya ntchito, kufufuza, kulankhula, kulemba, ndi kuyendayenda padziko lonse lapansi. Dr. Pierpaoli adanena kuti ngati angabwererenso kumudziwa, amayamba kumwa melatonin ali ndi zaka 30.
Dr Pierpaoli akutsindika kuti melatonin imakhala ngati mahomoni amtundu wa hormonal, kumathandiza kuchepetsa mahomoni a adrenal, chithokomiro ndi kubereka, komanso kusunga usiku, mwezi uliwonse, nyengo ndi nthawi zonse zamadzimadzi. Dr. Pierpaoli akukhulupiliranso kuti melatonin imachulukitsa kuchuluka kwa mapiritsi a estrogen m'magawo omwe amawoneka ngati mabere, chiberekero, ndi mazira, ndipo amamvetsa chidwi chawo.
Zina mwa zotsatira zina za melatonin zomwe zalembedwa ndi Dr. Pierpaoli zikuphatikizapo:
- kumathandizira kuti muyese kuchuluka kwa cortisol
- amaletsa atrophy wa mazira, maimba, ndi chiberekero
- kumapereka chonde
- imadzutsa HDL ("chabwino") cholesterol
- kuchepetsa kuthamanga kwa magazi
Dr. Pierpaoli anati:
Melatonin si hormona yokha, koma kwenikweni ndi "mfumukazi ya mahomoni onse," omwe amawatsogolera ndi kuwatsogolera onse "oimba a mahomoni".
Madokotala Ena pa Melatonin
Dr. Pierpaoli siye yekha woimira melatonin. Katswiri wa chithokomiro ndi mahomoni David Brownstein, MD , akuyamikira kuti melatonin imakhala "yotetezeka kwambiri," kwa odwala ambiri. Dr. Brownstein anati:
Mlingo wa mlingo wotsika wa melatonin ukhoza kukhala gawo lothandizira kwambiri la kusanganikirana kwa mahomoni. Sizothandiza kokha kuti tigone, koma zimathandizanso kuthandizira mahomoni ena, makamaka makamaka kusintha kwa T4 mpaka T3 kutembenuka.
Dr. Jacob Teitelbaum , yemwe amagwira ntchito ndi matenda osokonezeka , matenda a chithokomiro ndi a chithokomiro , amaganiza kuti mphamvu ya melatonin imachokera ku mphamvu yake yolimbikitsa kugona kwabwino. Dr. Teitelbaum anati:
Chimachitika ndi pamene simukugona, mukutsutsa dongosolo lonse. Kugona mokwanira ndikobwezeretsa ntchito ya hypothalamic. Ndipo melatonin ndi, pochepa, kuthandiza kuthandizira kugona bwino. Ndiponso, mu dongosolo lonse la mahomoni, pineal ikhoza kuwonedwa ngati mtsogoleri wa gulu lonse la oimba. Ngati ndiulesi, mavitamini ena onse akhoza kukhala opandaulesi.
Kuwonjezera pa Melatonin
Kodi mumaphatikizapo bwanji ndi melatonin?
Malingaliro a Dr. Pierpaoli ndi kutenga 3 mg ya melatonin yotulutsidwa nthawi, nthawi ya 11 koloko kapena ora musanakagone, zirizonse zoyambirira. Izi zimakuthandizani kuti mukhale ndi "kusungunuka kwa melatonin" panthawi yomwe thupi likhoza kulitulutsa.
Zotsatira zoyipa m'mabuku ochokera ku mlingo wochepa wa melatonin zikuwoneka ngati m'mawa kwambiri, maloto omveka bwino, ndi zoopsa, kapena mutu wofatsa utatha kugwiritsa ntchito pang'ono peresenti ya ogwiritsa ntchito. Ichi ndi chizindikiro chakuti mungathe kubwerera ku mlingo wapansi .
Malinga ndi katswiri wotchedwa hormone ndi chithokomiro Richard Shames, MD:
Mungayambe kuyamba ndi 3 mg, kenako muwone ngati mungapindule ndi 2 mg, ndiyeno mwinamwake mukhale 1 mg. Lingaliro langa ndiloti mlingo wa 1 mg sungathe kupweteka mutu ndi kupsinjika maganizo ngati zotsatira.
Paliponse palibe maphunziro omwe akhala akufalitsidwa nthawi yayitali pofufuza deta ya mlingo wotsika wa melatonin. Koma madokotala onse omwe ndalankhula nawo, ambiri omwe amagwiritsa ntchito mlingo wotsika wa melatonin okha ndipo amalimbikitsa odwalawo, akuganiza kuti chifukwa cha zotsatira za maphunziro afupikitsa, sitingapeze mavuto aliwonse ndi kugwiritsa ntchito nthawi yayitali mlingo wotsika wa melatonin. Melatonin sayenera kugwiritsidwa ntchito ndi amayi omwe ali ndi mimba kapena odyera.
Ngati mukufuna kuwonjezera pa melatonin, mutatha kulankhula ndi dokotala wanu, sankhani mtundu wanu mosamala. Mukufuna kutsimikiza kuti mukupeza mankhwala osungunuka a mankhwala otchedwa melatonin, ndipo akatswiri amasonyeza kuti mumagwiritsa ntchito makina a melatonin okha osati a melatonin ochokera kwa zinyama.
Nthaŵi zina mumamva kuti melatonin sivomerezedwa kwa anthu omwe ali ndi matenda okhaokha , komanso kwa amayi omwe ali ndi vuto la chithokomiro chifukwa cha matenda a Hashimoto kapena Graves, zomwe zingawonongeke. Imakali nkhani yotsutsana. Koma ndinamufunsa Dr. Pierpaoli za izi, ndipo adanena kuti pali vuto limodzi lokha limene melatonin imagwirizanitsidwa ndi matenda a chiwindi. Ananena kuti nkhaŵayi ndi yopanda maziko, kuti melatonin ikuwoneka kuti imathandiza chitetezo cha mthupi kugwira ntchito bwino, osati pa ntchito, monga otsutsa amasonyeza. Dr. Pierpaoli - pamodzi ndi madokotala ena omwe ndinayankhula nawo-amamva kuti melatonin ndi yothandiza pa matenda oponderezedwa. adalongosola chifukwa chake adayankha ku International Anti-aging Systems, mankhwala a UK:
Pankhani ya autoimmunity, melatonin iyenera kugwiritsidwa ntchito pa matenda omwe amadzimadzimadzimodzi chifukwa chakuti idzabwezeretsa chitetezo cha mthupi komanso mphamvu ya chitetezo cha mthupi kuti idziwe "antigen". Tawonatu kuti tikuchira! Zomwe zimadwalitsa matenda onse omwe amachititsa khungu, mafinya, magazi ndi ziwalo zina zimachokera ku chibadwidwe cha thupi kapena kupezeka kuti sitingathe kuzindikira matupi athu enieni. Kukalamba kwakukulu ndi njira yobisika, yosagwirizana ndi yosayenerera yomwe imayambitsa matenda a vasculitis (sclerosis of vessels), autoantibodies ndi khansa. Ntchito yathu ya zaka 40 yakhala ikuwonetseratu kuti chitetezo cha mthupi chimakhala pansi pa mphamvu ya mahomoni. Melatonin sichidzawonjezera kuyanjana kwa ma antiantibodies oopsa, mosiyana ndiwomwe amachititsa kuti machiritso amadzimadzi azitsitsimutso ndikuyambitsa njira yokhayokha.
Zotsatira:
Díaz, Beatriz López; Llaneza, Plácido Coto. "Malangizo a Endocrine a njira yoperekera mimba ndi melatonin ya m'kamwa: lipoti loyamba." Kusamba kwa nthawi . 15 (2): 388-392, March / April 2008.
Parry, Barbara, ndi. al. "Melatonin yowonjezereka ndi kuchepetsedwa kwapadera pa matenda a mitsempha ya m'mimba: Udindo wa Zaka Zakale Zam'mbuyomu, Kuthamanga Kwambiri, Kutentha Kwambiri, ndi Mndandanda wa Misa ya Thupi" Journal of Clinical Endocrinology & Metabolism . Yofalitsa pa Intaneti: July 02, 2013 Online.
Pierpaoli, Walter "Kusintha Kukalamba: Kukonzanso Pineal Clock." December 2005, Wiley-Blackwell. Online.
Toffol, Elena et. al. "Melatonin azimayi omwe amachititsa kuti anthu azikhala ndi matendawa: amacheza ndi maganizo, kugona, zizindikiro, komanso khalidwe labwino," Kutha msinkhu . May 2014 - Buku Lachiwiri - Gawo 5 - p 493-500