Olemekezeka Wapamwamba T3 akugwirizana ndi Matenda Osatroidal
Musamadzimve nokha ngati simunamvepo za mayeso a magazi omwe amatchedwa T3 (r3), omwe amadziwika kuti reverse triiodothyronine. Izi ndizoyezetsa magazi zomwe sizimangotumizidwa ndi madokotala a chithokomiro, kupatula ngati akudwala matenda aakulu (ganizirani munthu yemwe akuchipatala kuchipatala chachikulu).
Tiyeni tiyang'ane kuyang'anitsitsa kuyesa kwa magazi kwa chithokomiro, ndipo mtsutsano wokhudzana ndi tanthauzo lake lenileni.
Kodi T3 ndi chiyani?
RT3 ndi tetabolite ya T4 (thyroxine). Kawirikawiri, pamene T4 imataya atomu ya ayodini-njira yotchedwa monodeiodination, kapena T4 mpaka T3 kutembenuka-imakhala triiodothyronine (T3), mavitamini otulutsa chithokomiro.
Koma nthawi zina, thupi limateteza mphamvu potembenuza T4 mmalo mwa rT3, mawonekedwe osayenerera a T3 omwe sangathe kutulutsa oksijeni ndi mphamvu ku maselo, monga momwe T3 imachitira.
Kuyeza Kutembenukira T3
RT3 ikhoza kuyesedwa ndi mayeso a magazi.
Amadalitsidwa mosavuta ndi madokotala, kupatulapo ngati akudwala kwambiri, odwala kuchipatala omwe amawoneka kuti ali ndi mayesero oopsa a chithokomiro-kawirikawiri amakhala otsika kapena otsika kwambiri TSH, otsika triiodothyronine (T3) ndipo mwina otsika thyroxine (T4).
Pofuna kutanthauzira bwino zowonjezera izi (kudziwa ngati munthu wodwala kwambiri ndi hypothyroid kapena ali ndi matenda a nonthyroidal), rT3 imatengedwa.
Nonthyroidal Illness Syndrome
Matenda osasroidy, omwe amadziwikanso kuti euthyroid-matenda syndrome, amatanthauza kuchuluka kwa matenda a chithokomiro okhudza magazi omwe amapezeka pochitika matenda aakulu kwa munthu amene alibe vuto la chithokomiro. Pambuyo pochira matenda oopsa, chithokomiro cha ntchito ya chithokomiro chiyenera kukhala chachizolowezi.
Mu matenda a nonthyroidal, rT3 kawirikawiri imakwezeka, chifukwa chotsutsana ndi thupi la zina. Mukatikati mwa hypothyroidism, rT3 ndi yochepa.
Chifukwa chake, chiwerengero cha rT3 chokwanira pakadwala matenda aakulu chimathandiza madokotala kuti asapatsidwe matenda a hypothyroidism.
Chifukwa chakuti m'thupi losawonongeka, kutsekemera kwa majeremusi kumatengedwa ngati njira yoteteza (monga akatswiri ena), madokotala samalimbikitsa mankhwala.
Komabe, chisankho choyambitsa kapena chithandizo cha matenda osachiritsika sichikutsutsana. Akatswiri ena amakhulupirira kuti matenda a nonthyroidal amasonyeza kuti minofu ya hypothyroidism ilipo. Choncho, amakhulupirira kuti munthuyo ayenera kupatsidwa mankhwala a chithokomiro (kapena ngakhale hypothalamic release) ngati ma thyroxine ali m'munsi mwa msinkhu winawake.
Kupitabe patsogolo, ndizofunika kuzindikira kuti pambali pa matenda aakulu, matenda ena omwe angayambitse matenda osakroidia ndi awa:
- Njala
- Opaleshoni
- Kugwiritsidwa ntchito kwa mafupa a mafupa
- Matenda amtima
- Mitsempha ya Coronary imadutsa pamtengowo
Maganizo Ogwiritsira Ntchito Mankhwala pa RT3
Ndizoyenera kuzindikira kuti akatswiri ena a ma hormone ali ndi malingaliro osiyana pa udindo ndi kufunika kwa rT3, pokhulupirira kuti magulu akuluakulu a RT3 (ngakhale kuti TSH, Free T3, ndi Free T3 zikhoza kukhala m'zinthu zofanana ) zingasonyeze vuto la chithokomiro pamlingo wam'manja-nthawi zina amatchedwa "cell hypothyroidism."
Malinga ndi malingaliro awa, chiwerengero cha rT3 chokwera chingayambitsidwe chifukwa chakumangika thupi, nkhawa, matenda oopsa, matenda oopsa, ndi matenda ena aakulu.
Malinga ndi ophatikizira, njira imodzi yothetsera vuto la RT3 ndi "hypothyroidism" ndi kudzera mu chithokomiro ndi mankhwala omwe ali ndi T3.
Mawu Ochokera
Uthenga wobwerera kunyumba ndikutanthauza kuti tanthawuzo kapena kutanthauzira kwa tT3 kumayesedwa kunja. Tikukhulupirira kuti kafukufuku wambiri pa odwala odwala omwe ali ndi matenda akuluakulu a rT3 adzachitidwa (monga izi sizinafufuzidwe mu maphunziro akuluakulu, osasintha).
> Zotsatira:
> DeGroot LJ, Chrousos G, Dungan K, ndi al., Olemba. (2015). South Dartmouth (MA): MDText.com, Inc. &
> Ross DS. (2017). Chithokomiro chimagwira ntchito mu matenda osatroidal. Cooper DS, ed. Zaposachedwa. Waltham, MA: UpToDate Inc.
> Van den Berghe G. Matenda omwe sakhala ndi chithokomiro ku ICU: matenda omwe ali ndi nkhope zosiyana. Chithokomiro. 2014 Oct; 24 (10): 1456-65.