Malingaliro Osokoneza Kuchokera Phunziro Losaipitsidwa
Anthu omwe sakhala ndi mahomoni otere a chithokomiro, motero amakhala hypothyroid -benefit kuchokera ku levothyroxine , kapena hormone yokhazikika ya chithokomiro. Kutentha kwa ma chithokomiro n'kofunika kuti thupi likhale loyenera. Kawirikawiri, kayendetsedwe ka mahomoni a chithokomiro amabweretsa mavuto pang'ono, ndipo kuwonjezera pa zinthu ndizosawerengeka. Zina mwa zotsatira zoipa zomwe zimakhalapo zoipa zimaphatikizapo zikhomo, kuwonjezeka kwa mtima, kuthamanga, kutuluka thukuta, ndi mantha.
Komabe, kufufuza kwatsopano kumagwiritsa ntchito kugwiritsa ntchito levothyroxine (Synthroid) nthawi zonse ndi khansa ya chithokomiro . Ngakhale chidwi, phunziro laling'ono ili silimveka ndipo likusowa kufufuza.
Kafukufuku
Mu nkhani ya July 2017 yomwe inalembedwa mu Journal of Clinical Pharmacology , olemba Hung ndi olemba anzawo anafufuza mgwirizano pakati pa levothyroxine ndi kansa ya chithokomiro pogwiritsa ntchito kafukufuku wa anthu. Kujambula kuchokera ku deta yomwe ikuimira anthu 1 miliyoni a ku Taiwan, Hung ndi ogwira nawo ntchito adapeza anthu 1285 omwe adalandira nthawi yoyamba khansara ya chithokomiro pakati pa 1 January 2001, ndi 31 December 2013.
Anthu akuluakulu omwe ali ndi khansara ya chithokomiro anali ofanana ndi akuluakulu 3855 omwe alibe khansa ya chithokomiro (ie, gulu lolamulira) omwe anali ofanana m'zaka, kugonana, ndi madokotala. Pafupifupi, panali akulu 5140. Pakati pa anthu akuluakulu 5140, ofufuzawa anapeza akulu 70 omwe anapezeka ndi hypothyroidism ndi katswiri wa sayansi yamakono koma analibe mbiri ya opaleshoni ya chithokomiro.
Zotsatira zinasinthidwa pokhudzana ndi ndalama zamwezi, malo, kumidzi, kugwiritsira ntchito fodya, ndi matenda osiyanasiyana. Mwachidule, anthu 70 omwe ali ndi hypothyroidism amasiyana m'njira imodzi yaikulu: kansa ya kansa ya matenda.
Hung ndi anzake adapeza anthu 37 achikulire omwe ali ndi hypothyroidism omwe adakali ndi khansa ya chithokomiro.
Anadziwanso akuluakulu 33 omwe ali ndi hypothyroidism omwe sakhala ndi kansa ya chithokomiro. Ofufuzawo anayerekezera magulu awiriwa potsata zinthu zambiri, kuphatikizapo kugwiritsa ntchito levothyroxine nthawi zonse.
Ofufuzawa anapeza kuti akuluakulu omwe ali ndi kansa ya chithokomiro amapezeka kuti ali ndi matenda oopsa, matenda a shuga, osteoporosis, ndi hyperlipidemia.
Chodabwitsa kwambiri, Hung ndi anzake adapeza kuti akuluakulu omwe ali ndi hypothyroidism omwe nthawi zambiri amatenga levothyroxine amakhala ndi khansa ya chithokomiro. Komabe, levothyroxine yosavomerezeka imagwiritsa ntchito khansa ya chithokomiro.
Chithokomiro cha Hormone ndi Khansa
Matenda a chithokomiro ndi ofunikira kukula, chitukuko, ndi kagayidwe kake. Chifukwa khansa imatanthawuza kugawidwa kwa ma cell osayendetsedwa, zakhala zikugodometsedwa kuti hormoni ya chithokomiro ingathe "kuyambitsa" khansa. Kwa anthu, kafukufuku wowerengeka ndi kafukufuku wochepa amathandizira lingaliro lakuti mahomoni a chithokomiro amachititsa khansa.
Zochititsa chidwi, mu kafukufuku wa 2009 wotchedwa "Thyroid Function ndi Cancer Risk: Chidziŵitso Chachiwerengero cha Anthu," Hellevik ndi alembi ena anapeza mgwirizano pakati pa mahomoni otentha a chithokomiro ndi mitundu ina ya khansa. Anatsata a Norway okwana 29,691 zaka 9. Kumayambiriro kwa nthawi yofufuza, palibe aliyense mwa anthuwa amene anapezeka ndi matenda a chithokomiro.
Ofufuzawa adapeza kuti anthu omwe anali ndi chiwopsezo chotchedwa thyrotropin kumayambiriro kwa phunzirolo, omwe ali okhudzana ndi hyperthyroidism, anali pachiopsezo chachikulu cha khansa yapakhungu ndi prostate. (Panalibe mgwirizano pakati pa hyperthyroidism ndi kansa ya colon kapena khansara ya m'mawere.)
Komanso, Hellevik ndi anzake adapeza kuti hypothyroidism sagwirizana ndi khansa.
Komanso, kafukufuku wina amasonyeza kuti anthu omwe amapanga tizilombo toyambitsa matenda atapezeka kuti ali ndi khansara ya mutu ndi khosi amakhala motalika. Kuwonjezera apo, anthu omwe ali ndi khansa ya m'mawere omwe amadwala matenda a chithokomiro-ndipo motero hypothyroidism-akhoza kukhala motalikitsa, nawonso.
Mwa kuyankhula kwina, kafukufuku wina amatsimikizira kuti mwina kuchepa kwa chithokomiro kungateteze zotsatira za khansa. Mu maphunziro a zinyama, levothyroxine yasonyezedwa kuti ikulimbikitse kukula kwa mimba ndi kufalikira. Komanso, hypothyroidism imachepetsa kukula kwa mimba, imachepetsa kufalikira kwa chifuwa, komanso zimapangitsa kuti munthu apulumuke.
Njira
Chithokomirocho chimatulutsa hormone yotchedwa hormone yothandizira (TSH) . Kutentha kwa mahomoni a chithokomiro monga levothyroxine kumaphwanya ma sitirola a TSH ndi zolakwika. Popanda TSH, chithokomiro chimataya cholinga komanso chimataya. Pachifukwachi, mahomoni a chithokomiro amagwiritsidwa ntchito ngati mankhwala opatsirana pogwiritsa ntchito mankhwala a chithokomiro ndi goiters.
Intuitively, chithokomiro chochepetsetsa sayenera kukhala odwala khansa. Komabe, ndi levothyroxine maulamuliro, zimaganiziridwa kuti mazamu apamwamba a mahomoni a chithokomiro akhoza kuthana ndi vutoli ndikupangitsa khansa.
Ngakhale kuti mawotchiwo sakudziwika bwino, levothyroxine mwina akhoza kugwiritsira ntchito kapangidwe kake. Mwa kuyankhula kwina, levothyroxine akhoza kusewera mwachindunji kapena mwachindunji pa mapangidwe otupa. Malingana ndi Hung ndi olemba anzawo:
Pakalipano, zikuwoneka kuti palibe maphunziro omwe akufotokoza njira zothetsera matenda a thyroxin-carcinogenesis. Komabe, chodabwitsachi chingathe kufotokozedwa m'njira ziwiri. Choyamba, thyroxin ikhoza kukhala ngati wothandizira mu njira yeniyeni ya carcinogenesis .... Chachiwiri, thyroxin yokha ingakuthandizeni kukula kwa maselo a khansa ya chithokomiro.
Kodi izi zikutanthauza chiyani?
Kutengedwa ndekha, kufufuza uku kupeza kuti kawirikawiri levothyroxine imagwiritsidwa ntchito kumapeto kwa khansa ya chithokomiro imatanthauza pang'ono. Zotsatira izi zimachokera pa phunziro lokhalo la kafukufuku lomwe linali lochepa. Komanso, pangakhale zovuta ndi kafukufuku.
Choyamba, anthu ochepa omwe amatenga levothyroxine kwa hypothyroidism amayamba khansa ya chithokomiro kapena mitundu ina ya khansa. Mwachindunji, Hung ndi anzake adapeza kuti 2,88 peresenti ya maphunziro omwe ali ndi hypothyroidism adapanga khansa ya chithokomiro. Komanso, 0,86 peresenti ya maphunziro popanda hypothyroidism adayamba kukhala ndi kansa ya chithokomiro.
Chachiwiri, phunziroli ndilo loyamba kusonyeza mgwirizano pakati pa ntchito ya levothyroxine nthawi zonse ndi khansa ya chithokomiro. Kumbukirani kuti mgwirizano ndi wosiyana ndi chifukwa. Ofufuzawo sanatsimikizire kuti levothyroxine imayambitsa khansa ya chithokomiro.
Malingana ndi Hung ndi olemba anzawo:
[A] Ngakhale kuti zofukufukuzo zikusonyeza kusonkhana pakati pa khansa ya chithokomiro ndi ntchito yowonongeka ya thyroxin, maphunziro owonjezereka amafunika kuti apitirize kufufuza ndi kutsimikizira zotsatirazi .... Ngakhale kuti gawo lanu la thyroxin mu chitukuko cha khansayi liyenera kufufuzidwa, madokotala angaganizire mabungwe amenewa pamene akuchiza odwala ndi subclinical hypothyroidism.
Olembawo amavomereza mosavuta kuti zomwe apeza ndi mabungwe omwe amafunika kuwatsata chifukwa cha kufufuza kwina. Phunziroli ndiloling'ono ndipo tikusowa zazikulu zosiyana siyana kuti tipeze mgwirizano uliwonse.
Chochititsa chidwi ndi kuti olembawo amalangiza anthu kuti madokotala azitha kusunga gululi polemba odwala levothyroxine omwe ali ndi subclinical hypothyroidism, kapena kutaya kwa chithokomiro. Malangizowa mwina mwamsanga.
Chachitatu, mfundo zoyambirira za kafukufuku zingakhale zolakwika. Makamaka, ochita kafukufuku samasiyanitsa pakati pa zifukwa zosiyanasiyana za hypothyroidism. Mild hypothyroidism, yomwe ingafune kugwiritsidwa ntchito mobwerezabwereza ndi levothyroxine, ndi yosiyana ndi hypothyroidism, yomwe ingagwiritse ntchito kugwiritsa ntchito levothyroxine, ndipo kusiyana kwakukulu kumeneku kungawerengere kuchulukitsa kwa khansa yomwe imapezeka pakati pa ogwiritsa ntchito thyroxine. Ofufuza ndi apulo ndi malalanje.
Chachinayi, ofufuzawa anagwiritsa ntchito deta ya inshuwalansi pofuna kufotokoza ntchito ya chithokomiro nthawi zonse komanso yosadziwika, yomwe ndi njira yokayikitsa.
Mawu Ochokera
Ngati osatulutsidwa, hypothyroidism ikhoza kukhala yovuta komanso yovuta. Anthu omwe ali ndi hypothyroidism amatha kutopa, kudzimbidwa, kuvutika maganizo, khungu louma, phindu lolemera, ndi zina zambiri. Levothyroxine ndi mankhwala othandiza kwa hypothyroidism ndipo angathe kusintha khalidwe la moyo. Anthu ambiri amatenga levothyroxine tsiku lililonse popanda mavuto.
Ngati dokotala wanu wakuuzani kuti mukhale ndi levothyroxine wokhazikika kuti mupewe matenda a hypothyroidism, musamangodandaula kwambiri ndi mankhwalawa opangitsa khansa. Kwa anthu ambiri, ubwino wa levothyroxine umaposa zotsatira zake zonse, kuphatikizapo khansa yotheka. Kuwonjezera apo, phunziroli logwirizanitsa levothyroxine kawirikawiri ntchito ndi khansara ya chithokomiro ndi yaing'ono ndipo ingakhale ndi vuto ndi kupanga. Potsirizira pake, mgwirizanowu umene ochita kafukufukuwo akukonzekera amafunikiradi kufufuza zochulukirapo asanayambe kulongosola zowonjezereka.
Musagwiritse ntchito mankhwala a mankhwalawa chifukwa choopa kansa ya chithokomiro pogwiritsa ntchito kamphindi kakang'ono kameneka, kamene kamakhala kolakwika. Ngati nthawi zonse mumatenga levothyroxine pansi pa dokotala wanu, chonde pempherani ndi dongosolo la mankhwala. Kusintha kulikonse mu dongosolo lanu la mankhwala muyenera kukambirana ndi dokotala wanu.
Ngati mukudandaula za kugwirizana pakati pa levothyroxine ndi khansara ya chithokomiro-kapena china chirichonse, chonchi-chonde lembani izi ndi dokotala wanu wamaganizo kapena dokotala wamkulu . Mwa kufunsa mafunso, simangomasula zokhazokha komanso mumaphunzira zambiri za vuto lanu. Insight ndi mbali yofunikira ya chithandizo.
> Zosowa
> Cantrell F. Mutu 150. Hormone ya Chithokomiro. Mu: Olson KR. eds. Kuchepetsa & Kudyetsa Mankhwala Osokoneza Bongo, 6e New York, NY: McGraw-Hill; 2012.
> Hellevik, AI, et al. Ntchito ya Chithokomiro ndi Ngozi ya Khansa: Phunziro la Anthu Odziwika. Cancer Epidemiology, Biomarkers & Kupewa. 2009; 18: 570-574.
> Hung, SH, Chung, SD, Lin, HC. Kugwiritsa Ntchito Tizilombo Kumayenderana Ndi Kuopsa Kwambiri kwa Khansa ya Chithokomiro kwa Odwala Ndi Hypothyroidism. Magazini ya Clinical Pharmacology. July 19, 2017. (e-pub patsogolo kusindikiza)
> Stoll, SJ, et al. Kusintha kwa Hormone ya Chithokomiro Pambuyo pa Chithokomiro Chothandizira Chithokomiro. Opaleshoni. 2009; 146: 554-560.