Masewera Okhudza Mafunso Okhudzana ndi Matenda a Mankhwala Osokoneza Bongo
TNF inhibitors ndi mankhwala ochizira nyamakazi ya nyamakazi. Monga ndi mankhwala aliwonse, akhoza kukhala othandiza kwa anthu ena komanso osachepera. Tawonani zomwe TNF zimayambitsa ndi momwe zimagwirira ntchito, zomwe zingakhale zovuta, komanso momwe zimagwirizanirana.
Kodi TNF inhibitors ndi chiyani?
TNF inhibitors ndi opambana, mankhwala ovuta omwe ali mu kalasi ya mankhwala otchedwa biologics.
Amagwira ntchito pogwiritsa ntchito chinthu chomwe chimatchedwa tumor necrosis chomwe chimayambitsa kutupa. Mabakiteriya ena ochizira matenda a nyamakazi ndi ma antibodies ovomerezeka.
Biologics ndi mankhwala omwe amayambitsa makompyuta omwe amachititsa kutupa ndi ziwalo zowonongeka. Nthawi zambiri amalembedwa kwa anthu omwe akumwa mankhwala ena a nyamakazi, monga DMARD (matenda osinthira mankhwala osokoneza bongo), koma osapeza mpumulo wokwanira.
Kodi Chotupa cha Necrosis N'chiyani?
Matenda a Necrosis Factor ndi mapuloteni opangidwa ndi chitetezo cha mthupi. Zimathandiza pazinthu zina zofunika kwambiri, monga mafuta a mthupi komanso coagulation, kapena clotting, ya maselo a magazi. Zochitika zina, kuphatikizapo khansa ndi matenda omwe amadzimadzimadzimodzi monga nyamakazi ya nyamakazi, zimayambitsa kuchulukitsa kwa TNF, zomwe zimapangitsa kutupa.
Kodi Antioclonal Antibody N'chiyani?
Mukudziwa kale kuti ma antibodies ndi zinthu zopangidwa ndi chitetezo cha m'thupi kuti amenyane ndi ma antigen monga mavairasi.
Matenda a monoclonal amapangidwa mu labu ndipo amalinganiza kulunjika mamolekyu, monga TNF.
Kuyerekezera TNF Inhibitors
Ndikofunika nthawi zonse kuyang'ana kufanana ndi kusiyana pakati pa mankhwala pamene iwe ndi dokotala mukungoganizira za chithandizo chomwe chili chabwino kwa inu. Zina mwa zinthu zomwe muyenera kuziganizira posankha pakati pa TNF ndizopatsidwa momwe zilili, zotsatira zake, komanso mtengo.
Enbrel (etanercept) anali mankhwala oyamba a anti-TNF. Inavomerezedwa ndi US Food and Drug Administration (FDA) mu 1998. Enbrel imachokera pakuika DNA anthu ku Chinese hamster ovary maselo kuti apange mapuloteni opangidwa ndi mavitamini.
Remicade (infliximab) ndi anti-monoclonal antibody yomwe imamangiriza ndikuyimitsa chifuwa cha necrosis chifuwa cha alpha (TNF-alpha). Inali yachiwiri ya TNF inhibitor kuti ikhale ya FDA, mu 1999.
Huma (adalimumab) ndi "anti-humanistic" monoclonal antibody, kutanthauza kuti kupanga mankhwala enieni ndi ofanana ndi ma antibodies, ngakhale kuti adalengedwa mu labata. Humira adavomerezedwa ndi FDA mu 2002.
Cimzia
Cimzia (certolizumab pegol) ndiyo yokha yotetezera TNF yomwe imakhudza kukhala yochepa kwambiri kwa maselo chifukwa cha mankhwala ake. Kuonjezera apo, poyerekeza ndi mankhwala ena odana ndi TNF, Cimzia akuti ali ndi mgwirizano wapamwamba wa TNF ya anthu.
Mwachidule
Simponi (golimumab) ndi blocker ya TNF-alpha yomwe imaperekedwanso ku zilonda za ulcerative, nyamakazi ya psoriatic, ndi ankylosing spondylitis. Inavomerezedwa mu 2004.
Zotsatira za zotsatira za TNF Blockers
Palibe mankhwala omwe alibe zotsatira. Matenda ena omwe angagwirizane ndi TNF blockers amadziwika bwino, kuchititsa odwala matenda a nyamakazi kukhala osamala kuti atenge TNF inhibitors .
Koma kwa anthu ambiri, ubwino wake umaposa zoopsa.
Odwala ena amakhala ndi kachilombo ka HIV pamene akuchiritsidwa ndi DMARD kapena mankhwala osokoneza bongo. (N'chimodzimodzinso ndi DMARDs.)
Kafukufuku wa 2016 anapeza kuti anthu omwe anatenga matenda ena a TNF odwala nyamakazi anali ndi chiopsezo katatu chokhala ndi khansa, monga lymphoma. Izi zinali zowona ngati akadali pa mlingo waukulu.
Welengani zonse za izi
Arthritis Popanda Ululu - Chozizwitsa cha TNF Blockers
Bukuli lolembedwa ndi katswiri wa mafupa a mafupa a zinyama, Scott J. Zashin, MD, limafotokoza momwe TNF imagwirira ntchito komanso momwe imayerekeza ndi mankhwala ena a nyamakazi.
Amaphatikizapo nkhani zolimbitsa mtima ndikupita momwe gululi likugwiritsira ntchito mankhwala osintha.