Chotupa cha Necrosis Chotupitsa Chimachititsa Kutentha
Matenda a tumorcocis (TNF) ndi mankhwala opangidwa ndi maselo m'thupi lanu lomwe liri ndi zotsatira zambiri polimbikitsa njira yotupa . Amapangidwa mwachindunji ndi macrophages, mtundu wa selo loyera la magazi, koma amatha kupangidwa ndi maselo ena.
Chotupa cha Necrosis chakumtenda kuyankha kwa Immune
TNF ndi gawo lachidziwitso cha chitetezo cha mthupi ku maselo a tumimba, mabakiteriya, ndi mavairasi.
Imachita mbali zonse mukumveka kovuta ndi kutukusira kwadongosolo. Maselo amamasula iyo akazindikira chinthu china (antigen) chimene chachitsimikizika.
TNF ndi cytokine , puloteni yosonyeza. Ma cytokini ndi mankhwala omwe amapereka mauthenga pakati pa maselo m'thupi. Amagwira nawo mbali zambiri zowonongeka, kuphatikizapo:
- Kuchuluka kwa magulu
- Apoptosis, njira yachibadwa ya imfa ya selo
- Lipid (mafuta) mafuta
- Kugwirana, kapena kupanga mapangidwe a magazi
Chotupa cha Necrosis mu Matenda
TNF ikhoza kupangidwa mopitirira muyeso kapena mosayenera mu njira zosiyanasiyana za matenda. Izi zingabweretse kutupa kwanthawi zonse ndi zizindikiro zina zowononga. Matendawa ndi awa:
Chotupitsa Necrosis Factor ndi Chifuwa cha Matenda a Nyamakazi
Chotupitsa chiwalo cha alpha ndi chimodzi mwa maginito ofunika kwambiri omwe amagwiritsidwa ntchito mu nyamakazi ya nyamakazi pogwiritsa ntchito mpweya wochita kutupa.
Kawirikawiri, thupi limatsegula TNF yambiri mwachibadwa. Koma mu matenda a rheumatic, izo zimakhalabe zokhazikika ndipo zimapangitsa kutupa kwambiri. Mankhwala osokoneza bongo a TNF apangidwa kuti athetse kuyankhidwa kotereku.
TNF Inhibitor Mankhwala Osokoneza Bongo
Anthu omwe ali ndi thanzi la matenda a nyamakazi , nyamakazi ya psoriatic , ndi matenda a Crohn akhoza kuchiritsidwa ndi TNF inhibitor mankhwala.
Mankhwala awa amamatira chifuwa cha necrosis-alpha, kuchipangitsa kuti icho chisagwire ntchito. Izi zimadodometsa ntchito yotupa komanso imateteza thupi lanu. Kwa anthu omwe ali ndi nyamakazi, amatha kuchepetsa kuwonongeka kwa mgwirizano. Mankhwala oyambirira adavomerezedwa mu 1998 ndi ena apangidwa. Iwo ali m'kalasi la mankhwala osokoneza bongo , omwe ndi mankhwala omwe amayambitsa mamolekyu pa maselo a chitetezo cha mthupi.
Mankhwala osokoneza bongo a TNF ndi awa:
- Enbrel (etanercept)
- Remicade (infliximab)
- Humira (adalimumab)
- Simponi (golimumab)
- Cimzia (certolizumab pegol)
Kugwiritsa ntchito TNF Inhibitors
Manambala a TNF samatengedwa pamlomo. Mmalo mwake, muyenera kuwajoya pansi pa khungu lanu kapena mumtambo wanu, kawirikawiri m'chiuno kapena mimba yanu. Malingana ndi malipoti odwala, kusintha kwa zizindikiro zanu kumayamba kuchitika pambuyo pa mankhwala awiri kapena atatu.
Ngati adokotala akuika chojambulira cha TNF, mudzaphunzitsidwa momwe mungayankhire nokha kotero kuti simukuyenera kupita ku ofesi nthawi iliyonse.
Ngati dokotala akulamula infliximab kapena golimumab, muyenera kupita kuchipatala cholowera kapena dokotala kwa maola atatu kuti mulandire chithandizo. Mankhwala awa sali ojambulidwa.
Zotsatira Zopweteka za Kutupa Necrosis Factor Inhibitors
TNF blockers angayambitse zotsatira.
Chofala kwambiri ndi malo opanga jekeseni, omwe kawirikawiri amathamangitsidwa komweko ndi kutsitsimula kapena kuyabwa.
Chiopsezo chowonjezereka cha matenda onse amtunduwu ndi chofunika kwambiri cha TNF blockers chifukwa amaletsa chitetezo chanu cha mthupi. Onetsetsani kuti dokotala akuyesani kuti muyesetse chifuwa chachikulu ndi chifuwa chachikulu cha hepatitis B musanayambe kumwa mankhwala.
> Zotsatira:
> Mauthenga pa Tumor Necrosis Factor (TNF) Oteteza (Ogulitsa monga Remicade, Enbrel, Huma, Cimzia, ndi Simponi). US Food and Drug Administration.
> TNF Inhibitors. American College of Rheumatology.
> TNF Tumor Factory Nthenda Kwa Anthu. National Institute for Biotechnology Information.