Chakumapeto kwa zaka za m'ma 1990, mankhwala oyamba a biologic adapita kumsika kukachiritsa nyamakazi . Enbrel (etanercept) inali yoyamba, koma sizinatenge nthaŵi kuti mankhwala ena a biologic apangidwe ndi kugulitsidwa.
Malinga ndi UpToDate ( mauthenga odalirika omwe amagwiritsidwa ntchito ndi madokotala ambiri ndi odwala kufunafuna zambiri zakuya zamankhwala).
"Majini modifiers, omwe amadziwikanso monga biologics, ndi mankhwala omwe anapangidwa kuti ateteze kapena kuchepetsa kutupa komwe kumawononga ziwalo. Zamoyo zamakono zimagwiritsa ntchito maselo a chitetezo cha mthupi, chophatikizana, ndi zinthu zomwe zimagwiriridwa palimodzi, zonsezi Zingayambitse kutupa ndi chiwonongeko chophatikizana. Pali mitundu yambiri ya biologics, yomwe imakhala ndi mtundu wina wa molekyulu yomwe imagwira ntchitoyi (chotupa necrosis factor, interleukin-1, ndi molecule zam'thunzi pa ma Tymphcytes T ndi B). "
Mankhwala Osokoneza Bongo ndi Zolinga Zawo
- Enbrel (etanercept), Remicade (infliximab), Huma (adalimumab), Simponi (golimumab), ndi Cimzia (certolizumab pegol) ndi mankhwala osokoneza bongo omwe amayambitsa tumor necrosis factor (TNF). Ambiri amatchedwa TNF blockers ndipo, makamaka, imodzi ya TNF blockers ndi yoyamba biologic mankhwala anayesa.
- Kineret (anakinra) imaletsa interleukin-1. Kawirikawiri amavomereza kuti ndi a biologic osagwira ntchito kuposa a TNF ndipo nthawi zambiri sagwiritsidwa ntchito.
- Orencia (abatacept) amachititsa kuti maselo T ayambe. Kawirikawiri, Orencia imasungidwa kwa odwala omwe ali ndi vuto lopweteka kwambiri la nyamakazi limene satha kupirira matenda awo ndi methotrexate ndi blocker ya TNF.
- Rituxan (rituximab) imachotsa maselo B. Apanso, mankhwalawa ndi osungira omwe ali ndi zotsatira zosakhutiritsa ndi methotrexate ndi blocker ya TNF.
- Actemra (tocilizumab) amagwira ntchito poletsa interleukin-6 receptor, motero amaletsa interleukin-6.
Ndani Ayenera Kuchitidwa ndi Zinthu Zamoyo?
Odwala omwe akhala ndi yankho losakhutiritsa kwa DMARD (matenda ogulira antirheumatic drugs), kaya ali okha kapena osakaniza ndi mankhwala ena a nyamakazi, kawirikawiri amakhala oyenera ku biologics. Poyerekeza ndi DMARD, biologics amagwira ntchito mwamsanga. Muyenera kudziwa ngati mukumvetsera masabata angapo ndikuyambitsa mankhwala osokoneza bongo.
Ndani Sayenera Kuchitidwa ndi Zinthu Zamoyo?
Tsoka ilo, pali odwala omwe sali oyenera kulandira mankhwala ndi mankhwala osokoneza bongo. Pali zifukwa zina zomwe zoopsa zingathe kupindula kwambiri phindu la mankhwala ndi mankhwala osokoneza bongo.
Mwachitsanzo, odwala omwe ali ndi mbiri yakale ya multiple sclerosis kapena lymphoma sangakhale abwino. Odwala omwe ali ndi matenda osokonezeka mtima amakhala osagonjetsedwa. Ndizoopsa kwambiri kugwiritsa ntchito mankhwala osokoneza bongo pamene wodwala ali ndi mbiri ya matenda aakulu kapena obwerezabwereza.
Kodi ndi zinthu ziti zomwe muyenera kugwiritsa ntchito?
Dokotala wanu adzakuthandizani kusankha bwino biologic kwa inu. Mtengo ndiwongolingalira. Inu ndi dokotala wanu muyenera kudziwa ngati inshuwalansi yanu yathanzi idzagwiritsira ntchito mankhwala omwe mumasankha-kapena kuti ndalama zanu zothandizira.
Onetsetsani kuti ndi zotsika mtengo kwa inu.
Kuganiziranso kwina kuli kosavuta. Kodi mankhwalawa amaperekedwa bwanji? Kodi mukuyenera kupita kuchipatala kuti mukachiritsidwe kapena zingakhale bwino kuti musankhe mankhwala amodzi omwe amachitidwa ngati kudzipiritsa? Kodi mankhwalawa amagwiritsidwa ntchito kangati pa sabata, kawiri pa sabata, sabata iliyonse, kapena mwezi uliwonse? Kodi mumakonda chiyani?
Ndiponso, nkofunikira kuti musankhe mankhwala omwe ali ndi mbiri yabwino, mwazinthu zina, mmodzi mwa akulu, osati watsopano, biologics? Izi ndizofunika kuziganizira chifukwa ngati mutasankha zomwe zimakuyenderani bwino, mumakhalabe ogwirizana ndi mankhwala anu.
Chitsime:
Maini RN ndi Venables PJW. Chidziwitso cha odwala: Chithandizo cha nyamakazi "Rumatoid arthritis" UpToDate.