Kuyeza Ngozi ndi Mapindu
Odwala nyamakazi nthawi zina amachita mantha ndi biologics , omwe amatchedwanso biologic reaction modifiers. Mankhwala oyambirira omwe amavomerezedwa ndi FDA chifukwa cha kutupa kwa nyamakazi anali mankhwala odana ndi TNF , omwe amatchedwanso TNF (tumor necrosis inhibitor). Pali mavuto akuluakulu okhudzana ndi matenda a TNF, monga matenda akuluakulu ndi lymphoma, kotero mantha ena sali olakwika.
Koma, si koyenera kuyeza kuopsa ndi phindu la mankhwala ndi TNF blockers?
Mankhwala a TNF, omwe amaonedwa kuti ndi a DMARD, amagwiritsa ntchito Enbrel (etanercept), Humira (adalimumab), Remicade (infliximab), Simponi (golimumab), ndi Cimzia (certolizumab pegol). Iwo ali ndi chiŵerengero chabwino cha phindu / pangozi. Mwa kuyankhula kwina, ngakhale kuti zotsatira zowopsa zingayambe, sizili zachilendo. Ndizodabwitsa kuti odwala ambiri amakhudzidwa kwambiri ndi kumwa mankhwalawa.
Mankhwala a TNF akhala akuphunzitsidwa kwa odwala kwa zaka zambiri ndipo akhala ali pamsika kuyambira 1998. Zilikuluzikulu zazikuluzikulu ndi mankhwalawa ndizoopsa za matenda aakulu kapena lymphoma. Ngakhale popanda kutenga TNF blockers, odwala matenda a nyamakazi ali ndi chiopsezo chowonjezereka chokhazikitsa mavuto awiri (matenda kapena lymphoma) poyerekezera ndi anthu ambiri. Ndipotu, odwala omwe ali ndi matenda aakulu a nyamakazi amatha kukhala ndi lymphoma kusiyana ndi omwe ali ndi matenda oopsa.
Pali umboni wosonyeza kuti mankhwala osokoneza bongo amachititsa kuti munthu akhale ndi kachilombo kosazolowereka, monga chifuwa chachikulu cha TB . Choncho, zimalimbikitsa kuti odwala onse ayang'anitsidwe ndi mayeso a khungu ndi chifuwa cha x-ray kuti aone ngati asanatuluke ndi TB asanayambe kumwa mankhwala a TNF.
Muyenera kukhala osamala kwambiri pogwiritsa ntchito TNF blockers ngati muli ndi shuga wodalira shuga kapena muli ndi chifukwa china chokhala ndi chiopsezo chotenga kachilombo ka HIV, matenda opatsirana, kapena zilonda.
Odwala ambiri amtunduwu amatha kuchita bwino kwambiri pa DMARD , monga Plaquenil (hydroxychloroquine), Azulfidine (sulfasalazine) kapena Rheumatrex (methotrexate) ndipo sangayesedwe kutsegula TNF. Odwala omwe ali ndi matenda aakulu ndipo ali ndi zifukwa sayenera kutenga methotrexate (mwachitsanzo, matenda a chiwindi), TNF blockers angagwiritsidwe ntchito ngati mankhwala oyamba.
Mfundo Yofunika Kwambiri
Ngati mwalembera mtengo wa TNF ndikuvomera kuyesera, kumbukirani kuti:
- Dziwani zotsatira zomwe zingagwirizane ndi TNF blockers.
- Khalani maso. Samalani ndi zizindikiro zatsopano zomwe zingakhale zikukonzekera mutayamba kuyimitsa TNF.
- Musamatsutse zizindikiro zatsopano. Lembani kusintha kwa dokotala wanu ndipo mulole dokotala wanu asankhe kufunika kwake ndi zomwe ziyenera kuchitidwa.
- Pamene kuzindikira ndi kuonetsetsa n'kofunika pamene mukuyamba mankhwala atsopano, makamaka omwe ali ndi zotsatira zoopsa, kumbukirani kuti zotsatira zambiri kapena zotsatira zoipa sizodziwika. Sungani mantha anu ndi zenizeni.
- Kambiranani ndi dokotala nkhawa zanu. Fufuzani phindu potsata zoopsa za mankhwala ndi TNF blocker. Talingalirani kuopsa kwa chikhalidwe chanu, zinthu zovuta , komanso njira zina zamankhwala. Pamodzi ndi dokotala, pangani ndondomeko ndikumvetsetsa zolinga za chithandizo komanso zomwe zidzakhala zochitika ngati chinachake chingawonongeke.
Chitsime:
Yankho loperekedwa, mwachindunji, ndi Scott J. Zashin, MD Dr. Zashin ndi pulofesa wothandizira pa yunivesite ya Texas Southwestern Medical School ndi dokotala yemwe amapita kuchipatala cha Presbyterian ku Dallas ndi Plano. Dr. Zashin ndi mlembi wa Arthritis Popanda Mavuto - Chozizwitsa cha TNF Blockers ndi co-author of Natural Arthritis Treatment .