Cimzia ndi bokosi la TNF limene limagwiritsa ntchito nyamakazi yotupa
Cimzia (certolizumab pegol) ndi blocker ya TNF (tumor necrosis factor) -nso mankhwala omwe amagwiritsa ntchito monga Enbrel (etanercept) , Remicade (infliximab) , Humira (adalimumab) , ndi Simponi (golimumab). Cimzia ndi mankhwala okhawo m'kalasi la TNF lomwe limakhudza kukhala lochepa poizoni kwa maselo chifukwa cha mankhwala ake (mwachitsanzo, PEGylated, Fc dera laulere). Kuwonjezera pamenepo, poyerekeza ndi ena a TNF, Cimzia akuti ali ndi mgwirizano wapamwamba wa TNF wa anthu.
Kodi TNF Ndi Chiyani?
Zimathandiza kudziwa TNF kuti mumvetsetse chifukwa chake Cimzia amayesetsa kulepheretsa. TNF ndi cytokine , makamaka nthumwi ya maselo pakati pa maselo, omwe amachititsa ntchito yotupa . Kuchuluka kwa TNF-alpha yopangidwa ndi thupi kwagwirizanitsidwa ndi matenda angapo, kuphatikizapo nyamakazi ya nyamakazi .
Kodi Cimzia Inaperekedwa Motani?
Cimzia imayikidwa pansi pa khungu. Amaperekedwa monga ufa umene umayenera kuyanjanitsidwa kuti ukhale wowonongeka mwa madzi kotero kuti ukhoza kuperekedwa monga jekeseni wothandizira.
Wopanga, UCB, Inc., adanena kuti mankhwala omwe amadziwika bwino a Cimzia angakhale abwino kuposa omwe alipo a TNF odwala matenda a nyamakazi. Mapangidwe ake angachepetse kusintha koyambitsa jekeseni ndi mankhwala operekera ku malo otupa akhoza kupitsidwanso bwino, kumafuna dosing yocheperapo kusiyana ndi injini zina.
Pambuyo pa mlingo woyamba, pamakhala nthawi yowonongeka.
Cimzia ikhoza kuperekedwa pafupipafupi masabata awiri kapena anayi-kaya ali okha kapena ndi methotrexate.
Kuchita kwa Cimzia mu Zilinga Zachidziwitso
Zotsatira zabwino zowona zachipatala zinafotokozedwa kwa Cimzia. Maphunziro awiri a gawo lachitatu anawonetsa phindu lalikulu pamene Cimzia anagwiritsidwa ntchito yekha kapena kuphatikiza ndi methotrexate mwa akuluakulu omwe ali ndi nyamakazi yogwira ntchito (ie, synovitis yogwira ntchito ).
Mwachidziwitso, phunziro la masabata 24 la FAST4WARD linawonetsa kuti 400 mg ya Cimzia, yoperekedwa kwa milungu iwiri iliyonse, amachepetsanso ululu ndi zizindikiro za matenda a nyamakazi ndi ntchito yabwino ya thupi poyerekeza ndi omwe ali pa placebo.
Maphunziro a RAPID adasonyeza ubwino wogwiritsa ntchito Cimzia pamodzi ndi methotrexate. RAPID1 inasonyeza phindu la nthawi yayitali pogwiritsa ntchito Cimzia mwa kupuma kwa zizindikiro, kukulitsa zokolola ndi umoyo wa moyo, ndi kuchepetsa kutopa. Phunziro lachiwiri la RAPID, lodziwika ndi dzina lakuti RAPID2, linasonyeza kuti Cimzia pamodzi ndi methotrexate zimasintha bwino kwambiri zizindikiro za matenda a nyamakazi, zomwe zimalepheretsa kuti matendawa apitirire, komanso kuti thupi likhale labwino kwa odwala omwe ali ndi nyamakazi.
Zotsatira zoyipa za Cimzia
Zotsatira zoyipa zapangitsa anthu ena kutenga Cimzia. Kufotokozera zomwe zilipo kwa Cimzia akuchenjeza za:
- Matenda aakulu, kuphatikizapo chifuwa chachikulu
- Khansara, kuphatikizapo lymphoma
- Matenda a misomali, kuphatikizapo multiple sclerosis
- Zosokonezeka
- Matenda a magazi
- Mtima watsopano kapena wowonongeka
- Zomwe zimayambitsa matenda, kuphatikizapo matenda a lupus
Zotsatira zofala kwambiri zomwe zimagwirizanitsidwa ndi Cimzia ndi matenda opumphulira apamwamba, matenda opatsirana m'makina, kupweteka kwa pamodzi, ndi zotsatira za jw.org.
Kodi Cimzia FDA-Yavomerezedwa?
Pa April 22, 2008, Cimzia anali a FDA adavomerezedwa kuti achuluke matenda a Crohn a anthu odwala omwe sanathandizidwe ndi mankhwala ochiritsira. Pa May 14, 2009, Cimzia inavomerezedwa ndi FDA kuti athetse odwala achikulire omwe ali ndi mphamvu yogwiritsira ntchito nyamakazi. Zisonyezo zawonjezeredwa ndi nyamakazi ya psoriatic ndi ankylosing spondylitis .
Cimzia imapezeka mu sering'i yodzazidwa isanafike yomwe imanyamula Arthritis Foundation's Ease-of-Use Commendation. Mapangidwe a syringe ndi zotsatira za mgwirizano pakati pa UCB ndi OXO (odziwika bwino chifukwa cha mzere wawo wa zipangizo zophika za ergonomic ndi zipangizo zina zowonongeka).
Zotsatira:
Cimzia. Kufotokozera Uthenga Wathunthu. UCB. Revised April 2016.
http://www.cimzia.com/assets/pdf/Prescribing_Information.pdf
Cimzia. Malangizo a Mankhwala. UCB, Inc. Revised April 2016.
http://www.cimzia.com/assets/pdf/MedicationGuide.pdf