Kusiyanasiyana kwakukulu mu Ulimbi, Ndalama, ndi Utsogoleri
TNF inhibitors (omwe amadziwikanso kuti TNF blockers) ndi kalasi ya mankhwala omwe amachepetsa kutupa mwa kutenthetsa chitetezo cha mthupi. Amagwiritsidwa ntchito kuthana ndi matenda osiyanasiyana omwe amadziwika ndi matenda a nyamakazi (RA) , psoriasis, psoriatic nyamakazi, ululu wa ulcerative, ndi matenda a Crohn.
Mankhwala atatu otchuka kwambiri a TNF omwe amagwiritsidwa ntchito popanga RA ndi awa:
Ngakhale mankhwala atatuwa amachititsa kuti thupi liziyankhidwa pa chotupa cha necrosis factor (TNF) - mtundu wa mapuloteni, wotchedwa cytokine . zomwe zimayambitsa kutupa-aliyense ali ndi mawonekedwe osiyana siyana komanso zothandiza komanso zoperewera.
Kodi TNF Inhibitors Zimagwira Ntchito Bwanji?
Tizilombo toyambitsa matenda a TNF ndi mtundu wa mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza matenda omwe amadzimadzimutsa ngati RA. Pamene akuwunikira makamaka TNF, zina zamoyo zomwe zimagwiritsidwa ntchito pogwiritsa ntchito cytokini monga interleukin kapena kusintha njira yomwe maselo amadzimadzi amatchedwa T-maselo kapena B-maselo amagwira ntchito.
Zizindikiro za TNF zakhala zida zofunika kwambiri pakuyang'anira ndi kulandira chithandizo cha RA kuyambira poyambira mu 1998. Iwo ali ndi mphamvu zoposa 70 peresenti ya anthu omwe ali ndi matendawa, kuphatikizapo omwe sanayankhe mzera woyamba wa methotrexate.
Pogwiritsidwa ntchito pamodzi ndi methotrexate, TNF inhibitors amadziwika kuti amagwira bwino kwambiri pobwezeretsa ubwino wa moyo wa odwala Edzi, kawirikawiri mwachidule ngati masabata 12.
Kusiyanasiyana kwa Administration
Ngakhale kuti ntchitoyi ndi yosiyana kwambiri ndi mankhwala atatuwa, Enbrel, Huma, ndi Remicade ali ndi kusiyana kwakukulu kosiyanasiyana. Mmodzi mwa iwo ndi kayendetsedwe ka mankhwala ndi mafupipafupi a dosing.
Ngakhale kuti mankhwalawa amagwiritsidwa ntchito mosiyanasiyana, amawauza motere:
- Enbrel imaperekedwa ndi jekeseni (mwachikopa) kamodzi kapena kawiri pa sabata.
- Humira imaperekedwa ndi jekeseni ya subcutaneous sabata iliyonse.
- Remicade imafuna kulowetsedwa mwachisawawa masabata makumi asanu ndi atatu mphambu asanu ndi atatu.
Komanso, mosiyana ndi Remicade, Enbrel ndi Humira akhoza kudzipangira okha ndi mlingo woyenera. cholembera chojambulidwa (monga omwe amagwiritsidwa ntchito ndi odwala matenda a shuga kuti ayambe insulin).
Kusiyana kwa Efficacy
Njira inanso imene mankhwalawa amasiyana ndi nthawi yokwanira yothandiza, kutanthauza kuchuluka kwa nthawi yomwe mungagwiritsire ntchito musanayambe kusintha mankhwala.
Kuti izi zitheke, kachitidwe kafukufuku mu 2013 ndi asayansi ku yunivesite ya Valladolid ku Spain anafufuza kawirikawiri mankhwala a Enbrel, Huma, ndi Remicade mwa anthu 91 omwe ali ndi RA.
Chimene iwo adapeza chinali chakuti Enbrel ndi Huma adakhala ndi mphamvu zoposa zaka zisanu ndi ziwiri (masiku 2,561 ndi masiku 2,769, motsatira). Poyerekeza, Remicade anali ndi nthawi yothandizira kwa zaka zoposa zisanu (1,853 masiku).
Pa mankhwala atatuwa, Enbrel anasonyeza kuti nthawi yayitali yakhala yothandiza kwambiri, makamaka mwa amayi omwe anakhalabe odwala pafupifupi pafupifupi zaka zisanu ndi zinayi (masiku 3,191). Komanso, anthu okalamba pa Enbrel sankasintha kwambiri kupita ku TNF.
Ngakhale kuti zogwirizana ndi zochepa ndi kukula kwa phunziroli, ofufuza anapeza kuti, mwa atatu atatu a TNF, Enbrel anawonetsa bwino kwambiri.
Kusiyana kwa Mtengo
TNF inhibitors onse ndi okwera mtengo kwambiri poyerekeza ndi mankhwala ena a RA, omwe ndi ofunikira kuchipatala chanu.
Ngakhale kuti mankhwalawa angathe kukhala abwino pambuyo pobwezera ndalama zothandizira inshuwalansi, kuchotsera malonda, ndi mapulogalamu othandizira odwala, mukhoza kuyembekezera kuti mtengo wonse ukhale wochepa mkati mwazigawo izi:
- Kulipira mtengo pakati pa $ 1,800 ndi $ 2,400 pamwezi.
- Enbrel amaposa $ 4,000 pa mwezi.
- Mlingo umodzi wa Remicade ukhoza kulipira kulikonse kwa $ 1,250 mpaka $ 2,500, malingana ndi momwe mukufunira kuwombera milungu iwiri kapena masabata asanu ndi atatu.
Ndi Remicade, nkofunikanso kuwerengera ndalama zomwe zimaperekedwa kuchipatala. Mosiyana ndi zimenezi, Enbrel ndi Huma sakanakhala ndi ndalama ngati mutasankha kudzipiritsa.
Pamapeto pake, mtengo weniweni wa chithandizo udzadalira pa inshuwalansi yanu komanso kuyenera kwanu kuti muthe kulipira ngongole monga opangidwa ndi Enbrel, Huma, ndi Remicade.
> Chitsime:
> Martinez-Santana, V ,; Gonzalez-Sarmiento, E ;; Calleja-Hernandez, M. et al. "Kuyerekeza kwa mankhwala osokoneza bongo chifukwa cha zotupa za necrosis zomwe zimatsutsana ndi nyamakazi ya nyamakazi." Odwala amafuna Kugwirizana . 2013; 7: 719-27. DOI: 10.2147 / PPA.S47453.