Yoyamba TNF Blocker Yavomerezedwa ku Matenda a Matenda a Nyamakazi mu 1998
Enbrel (etanercept) ndi biologic response modifier (kachilombo kamene kamene kamatulutsa timor necrosis factor receptor fusion protein). Enbrel imapangidwira kuti ikhale ngati ziwalo za thupi zomwe zimagwiritsa ntchito chifuwa cha necrosis factor (TNF-alpha). Enbrel imagwira ntchito potsegula TNF yochulukirapo musanayambe kugwirizanitsa ndi zovomerezeka zachilengedwe.
TNF-alpha ndi cytokine yomwe imagwira ntchito yotupa.
Mankhwala a TNF-alpha adagwirizanitsidwa ndi nyamakazi ya nyamakazi ndi mitundu ina ya nyamakazi yotupa .
Mankhwala Ofanana
Enbrel anali mankhwala oyamba a anti-TNF ndipo adavomerezedwa mu 1998 chifukwa cha matenda a nyamakazi ndi mitundu ina ya kutupa nyamakazi. Remicade (infliximab) inali yachiwiri ya TNF inhibitor kuti ivomerezedwe ndi US Food and Drug Administration mu 1999. Humira (adalimumab) inavomerezedwa mu 2002. Simponi (golimumab) inavomerezedwa ndi FDA pa April 24, 2009. Cimzia (certolizumab pegol ) inali yovomerezeka ndi FDA pa May 14, 2009.
Enbrel amachokera poika DNA m'magulu a ku China a hamster ovary ndi kupanga mapuloteni opangidwa ndi majini. Remicade amagwiritsa ntchito mapuloteni a anthu ndi a mouse kuti apange chimeric monoclonal antibody . Humira amagwiritsira ntchito mapuloteni a anthu komanso mapulogalamu apamwamba kuti azitha kupanga ma antibodies monoclonal.
Ulamuliro
Enbrel amagwiritsidwa ntchito monga jekeseni kamodzi kapena kawiri mlungu uliwonse (masiku atatu kapena 4 kupatula).
Mlingo umene wapatsidwa umadalira mkhalidwe umene ukuperekedwa. Enbrel ayenera kulamulidwa ndi dokotala wanu ndipo amafuna kuti inshuwalansi isanafike. Enbrel ingagwiritsidwe ntchito pamodzi ndi methotrexate kwa odwala omwe samayankha methotrexate okha.
Malemba
Enbrel yavomerezedwa kuti ikhale ndi nyamakazi yochepa kwambiri, yomwe imakhala yochepa kwambiri mpaka nyamakazi ya nyamakazi ya nyamakazi , nyamakazi ya psoriatic , ankylosing spondylitis , psoriasis yosakanikirana kwambiri.
Ndondomeko Yoperekedwa
Anthu akuluakulu odwala matenda a nyamakazi, nyamakazi ya psoriatic, ndi ankylosing spondylitis, mlingo wamba wa Enbrel ndi 50 mg pa sabata omwe amagwiritsidwa ntchito monga jekeseni wothandizira pogwiritsira ntchito 50 mg / ml osagwiritsiridwa ntchito siringi. Pali masamba 25 mg a Enbrel omwe aliponso.
Mlingo wa Enbrel womwe umaperekedwa kuti mwana azidwala nyamakazi amachokera kulemera kwake kwa mwana. Kusankhidwa kamodzi pamlungu mlungu uliwonse kulipo kwa ana olemera 138 lbs kapena kuposa. Kwa psoriasis ya plaque , mlingo wokhazikika ndi 50 mg kawiri pa sabata kwa miyezi itatu, umatsika kamodzi pamlungu.
Kuda nkhawa Kwambiri
Enbrel siyanzeru kwa amayi omwe ali ndi pakati kapena okalamba. Odwala omwe ali ndi matenda akuluakulu sayenera kuchiritsidwa ndi Enbrel. Anthu omwe ali ndi kachilombo ka HIV kapena omwe ali ndi matenda a shuga osagwiritsidwa ntchito sayenera kugwiritsa ntchito Enbrel. Odwala omwe ali ndi vuto linalake la m'magazi ayenera kutetezeranso Enbrel.
Zotsatira Zogwirizana
Zotsatira zofanana zomwe zimagwirizanitsidwa ndi Enbrel zikuphatikizapo:
- malingaliro a malo a jekeseni
- matenda opuma opuma, kuphatikizapo matenda a sinus
- mutu
- chizungulire
- mphuno yothamanga
- kupweteka kwa mmero
Zotsatira Zovuta Kwambiri
Enbrel akhoza kuonjezera chiopsezo cha matenda akuluakulu. Kwa anthu amene amachiritsidwa ndi Enbrel, pakhala pali malipoti a multiple sclerosis , myelitis (kutupa kwa msana wam'mimba), optic neuritis (kutupa kwa mitsempha ya optic), ndi pancytopenia (chiwerengero chochepa cha maselo ofiira, maselo oyera, mapereletiti).
Kusungirako
Enbrel iyenera kusungidwa kutentha kwa madigiri 36 mpaka 46 Fahrenheit. Komabe, Enbrel ikhoza kusungidwa kutentha kwa masiku 14. Enbrel sayenera kusungidwa mufiriji.
Malinga ndi enbrel.com, ngati mukuyenda maola angapo, muyenera kukulunga Enkhono mukulumikiza kwazowunikira ndikuyiyika paulendo wozizira wodzaza ndi ayezi. Onjezerani thermometer kwa ozizira ndikuziwona maola angapo ochepa. Mukhoza kupeza malo ozizira oyendayenda komanso ma pulogalamu yachitsulo ya Enbrel poitana Enbrel Support pa 1-888-4ENBREL. Ngati mukuyenda mlengalenga, fufuzani ndi ndegeyo chifukwa cha zofuna zawo.
Zotsatira:
Arthritis Popanda Ululu, Scott J. Zashin, MD, Wofalitsidwa ndi Company Sarah Publishing Publishing.
Enbrel - Book Pill, Edition 10
Malangizo a Mankhwala. Enbrel.com. Revised 11/2013. http://pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf
Kufotokozera Information. Enbrel.com. Kukonzedwanso 03/2015. http://pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf