Mankhwala ojambulidwa ndi jakisoni a nyamakazi
Adalimumab, omwe amadziwika kuti Humira, ndi mankhwala osokoneza bongo omwe amagwira ntchito potseka puloteni yotchedwa TNF-alpha . Kawirikawiri, TNF-alpha imathandiza kumenyana ndi matenda, koma mochulukirapo, imayambitsa kutupa kowawa komanso kuwonongeka kwakukulu (mwachitsanzo, zizindikiro zofala za nyamakazi ya nyamakazi ndi mitundu ina ya kutupa nyamakazi ). Mankhwala monga Humira athandiza anthu ambiri odwala matenda a nyamakazi pochepetsa kupweteka, kupititsa patsogolo mgwirizano, komanso kuchepetsa matenda.
Mwachidule
Humira ndi anti- nucleinal anti- humanized antibody . Izi zikutanthauza kuti, ngakhale kuti zimapangidwira mu machitidwe osakhala a anthu, zenizeni zapuloteni za mankhwala ndi zofanana ndi za ma antibodies. Ndipo Hume wotchukayu adachokera ku chophimba cha TNF cha monoclonal antibody chomwe chinavomerezedwa chisanafike-mapangidwe ake a mapuloteni amachokera ku mbali ya munthu wosagwira ntchito (anti-mouse).
Mu 2002, Humira adalandiridwa koyamba ndi US Food and Drug Administration (FDA) monga mankhwala odwala nyamakazi. Ndi imodzi mwa mankhwala osokoneza bongo omwe amalepheretsa TNF-alpha, kuphatikizapo:
- Enbrel (Etanercept) : Mankhwala oyamba a TNF omwe amavomereza ndi FDA chifukwa cha matenda a nyamakazi ndi mitundu ina ya kutupa nyamakazi mu 1998.
- Remicade (Infliximab) : Wachiwiri TNF inhibitor kuti avomerezedwe ndi FDA mu 1999.
- Simponi (Golimumab) : Yavomerezedwa ndi FDA pa April 24, 2009.
- Cimzia (Certolizumab Pegol) : Yavomerezedwa ndi FDA pa May 14, 2009.
Kusankha
Humira amaperekedwa ndi subcutaneous (pansi pa khungu) kudzipiritsa kamodzi pa milungu iwiri iliyonse. Odwala angalangizedwe ndi dokotala kuti adziyese mlungu uliwonse ngati masiku 14 sali okwanira.
Choyamba chinali chogwiritsidwa ntchito chimodzi, syringe yodzazidwa. Kugwiritsira ntchito kamodzi, njira yotulutsira yosamalidwa inakonzedwanso, yotchedwa Pen Humira.
Mlingo wovomerezeka, komabe, ndi 40mg monga kudzipiritsa tokha pogwiritsira ntchito sering'i yodzazidwa kale kapena pensulo ya Humira sabata iliyonse. Methotrexate , ma DMARD ena osakhala a biologic, glucocorticoids , mankhwala osakanikirana ndi anti-inflammatory (NSAIDs) , kapena analgesics (mankhwala opweteka) angapitirize pamene akuchitidwa ndi Humira. Komabe, ma DMARD ena a sayansi sayenera kugwiritsidwa ntchito.
Zisonyezo
Zowonjezera zowonjezera zawonjezeredwa kwa Huma kuyambira poyamba zinavomerezedwa ndi FDA. Zingaperekedwe kuti zithandizenso:
- Chifuwa chachikulu cha nyamakazi
- Ankylosing Spondylitis
- Psoriatic Arthritis
- Matenda a Amuna a Idiopathic Arthritis
- Plaque Psoriasis
- Ulcerative Colitis
- Matenda Achikulire ndi Matenda a Crohn
- Hidradenitis Suppurativa
Zotsatira Zotsatira
Zotsatira zofanana zomwe zimagwirizanitsidwa ndi Humira ndi izi:
- Tsamba lopweteka jekeseni
- Rash
- Mutu
- Mimba yodwala kapena nseru
- Chibayo
Zotsatira Zovuta
Chifukwa chimachepetsa chitetezo cha mthupi m'thupi lomwe limamenyana ndi matenda, Humira wakhala akugwidwa ndi matenda akuluakulu, monga chifuwa chachikulu, matenda a chifuwa chachikulu, ndi matenda a fungal. Zingakhalenso zoipitsa zizindikiro za matenda a mitsempha yamanjenje (mwachitsanzo, matenda osokoneza bongo). M'mayesero am'chipatala, odwala ena anali ndi chiwerengero cha khansa ndi lymphoma kwa miyezi 24.
Amene Saliyenera Kutenga Huma
Humira sayenera kugwiritsidwa ntchito ndi odwala omwe amadziwika bwino ndi mankhwala kapena zigawo zake. Siyeneranso kugwiritsidwa ntchito ndi odwala amene ali ndi pakati kapena akuyamwitsa.
Mankhwala sayenera kulembedwa kwa wodwala amene ali ndi matenda oopsa kapena odwala omwe amatengedwera ku matenda, kuphatikizapo odwala matenda a shuga osatetezedwa kapena odwala omwe ali ndi mbiri ya matenda opatsirana.
Uzani Dokotala Wanu
- Ngati muli ndi matenda opatsirana
- Ngati mwapezeka ndi matenda a Hepatitis B kapena muli chonyamulira (Humira akugwirizananso ndi kukonzanso kachilombo ka hepatitis B)
- Ngati muli ndi zofooka, zovuta, kapena multiple sclerosis kapena matenda aakulu a mitsempha
- Ngati mwachitidwa kuti muthetse mtima
- Musanayambe kulandira katemera kapena opaleshoni iliyonse
Kufotokozera zotsatira zolakwika, mungathe kuonana ndi AbbVie Inc.at 1-800-633-9110 kapena FDA pa 1-800-FDA-1088 kapena www.fda.gov/medwatch.
Zotsatira:
Zashin, MD, Scott J .. Nyamakazi Yopanda Chisoni. Gulu la Sarah Publishing la Sarah Allison.
Humira . Abbott ma laboratories. Kufotokozera Information. 2016.