Chiboliboli (mankhwala opatsirana pogwiritsa ntchito mankhwala)

Kulemba:

Mtundu wa tybost (cobicistat) ndi mankhwala omwe amadziwika ngati CYP3A inhibitor yogwiritsidwa ntchito pochiza HIV . Tybost imagwira ntchito polimbikitsa " mankhwala" a mankhwala a antiretroviral, Vitekta (elvitegravir), Reyataz (atazanavir) ndi Prezista (darunavir) , pamene amagwiritsidwa ntchito palimodzi mankhwala ochepetsa antiretroviral (MAP) .

Tybost ndi gawo limodzi la magawo atatu omwe amadziphatikiza mankhwala, Stribild (elvitegravir + cobicistat + tenofovir + emtricitabine) , Evotaz (atanazavir + cobicistat) ndi Prezcobix (darunavir + cobicistat) ,

Tybost inavomerezedwa ndi US Food and Drug Administration (FDA) mu September 2014 kwa odwala akuluakulu omwe ali ndi kachilombo ka HIV.

Fomu:

150mg pulogalamu yophimba mafilimu, yowala lalanje mtundu ndi zolemba ndi "GSI" kumbali imodzi.

Mlingo:

Piritsi imodzi ya 150mg imatengedwa tsiku ndi tsiku ndi chakudya panthawi imodzimodzi ndi Reyataz kapena Prezista. Mankhwalawa ayenera kuphatikizapo chimodzi kapena zambiri, zotsatizana ndi mankhwala ochepetsa kachilombo ka HIV.

Malangizo:

Asanayambe, odwala ayenera kuyesedwa kuti azindikire kuti ali ndi kachilombo koyambitsa matenda monga tybost. Pogwiritsidwa ntchito ndi Viread (tenofovir) -madokotala amadziwikiranso kuti amachititsa kuti thupi likhale lopweteka kwambiri.

Zotsatira zofanana:

Phunziro lachiwiri la anthu omwe amapita kuchipatala, zotsatira zochepa za mankhwala zomwe zakhalapo ndizogwiritsidwa ntchito pogwiritsa ntchito tybost.

Zochitika zovuta kwambiri, zomwe zimafotokozedwa mwa odwala 2% kapena osachepera, zinali:

• Jaundice (khungu la khungu ndi maso)
• Oter icterus (kutuluka kwa maso)
• Nausea
• Kutsekula m'mimba

Zotsatira zochepa zomwe zimagwiridwa ndi monga kutopa, kupweteka mutu, kusowa tulo, kusanza ndi ululu wamimba. Odwala ena adalinso ndi miyala yachitsulo pamene Tybost adatsogoleredwa ndi Reyataz ndi Viread, ngakhale kuti milanduyi inkawoneka yofatsa ndipo siidatengere chithandizo.

Kusiyanitsa Mankhwala:

Mtundu wa tybost suyenera kutengedwa ndi mankhwala awa:

• Mankhwala oletsa kugonana: Multaq
  
• Mankhwala a anti-cholesterol: Mevacor, Zocor
  
• Mankhwala a anti-gout: Uroxatral
  
• Mankhwala oletsa kuthamanga kwa magazi: Revatio
  
• Mankhwala otsutsa-psychotic: Orap
  
• Mankhwala a khansa: Camptosar, Campto (atagwirizanitsa ndi Reyataz)
  
• Zotsatira zotsutsana ndi miguine ya Ergot: DHE 45, Ergotrate, Hydergine, Migrana
  
• Mankhwala opatsirana pogwiritsa ntchito mankhwala a Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
  
• Zochitika: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
  
• Wotchedwa St. John's Wort

Kugwiritsa Ntchito Mankhwala Ochepetsa Matenda a Edzi:

Kugwiritsiridwa ntchito kwa Tybost ndi kutsatira mankhwala ochepetsa kachilombo ka HIV kungayambitse kapena kutaya mankhwala achikulire kapena kuwonjezeka kwa zotsatira zake:

• Crixivan (indinavir) sayenera kuyang'aniridwa ndi Tybost ndi Reyataz.
  
• Intelence (etravirine) sayenera kuyendetsedwa ndi Tybost.
  
• Sustiva (efavirenz) sayenera kuyang'aniridwa ndi Tybost ndi Prezista.
  
• Viramune (nevirapine) sayenera kuyang'aniridwa ndi Tybost ndi Prezista.
  
• Mlingo wa Selzentry (maraviroc) uyenera kusinthidwa kufika 150mg kawiri patsiku ngati uli wolamulidwa ndi Tybost.

Kuyanjana Kapena Kuganizira Zina:

• Udziwitseni dokotala wanu chilichonse chimene mukuganiza kuti muli ndi impso musanayambe Tybost.
  
• Antacids ndi aluminium kapena magnesium hydroxide amatha kulepheretsa Tybost / Reyataz kukwanira. Ngati mukugwiritsa ntchito mankhwala osokoneza bongo (mwachitsanzo, Rolaids, Tums, Milk of Magnesia), akuuzidwa kuti atenge maola awiri kapena am'mbuyomu ya Tybost / Reyataz.
  
• H ₂ -omwe amatsutsana nawo amaletsa m'mimba asidi (mwachitsanzo, Tagamet, Pepcid, Axid, Zantac) amatha kulepheretsanso kuyamwa kwa Tybost / Reyataz. Zimaperekedwa kuti azitengedwa ndi Tybost / Reyataz kapena, mwachindunji, ola limodzi kapena isanafike, kapena pambuyo pa chiwerengero cha Tybost / Reyataz.
  

• Proton pump inhibitors (mwachitsanzo, Losec, Prilosec, Prevacid, Nexium, Pariet) amatha kuletsa kutentha kwa Tybost / Reyataz. Amaperekedwa kuti atenge maola 12 chisanafike kapena pambuyo pa chiwerengero cha Tybost / Reyataz.
  
• Mankhwala ochepetsa matenda a Erectile (Viagra, Levitra, Cialis) ayenera kugwiritsidwa ntchito mosamala ngati tybost ingalimbikitse zotsatira zoyipa, kuphatikizapo kusokonezeka kwa maso, hypotension, ndi priapism (zopweteka, zowonjezera). Ndikoyenera kuti Viyeza ya kuchepa imachepetsedwe osapitirira 25mg mu maora 48; Mlingo wa Levitra ukhale wocheperapo mpaka 2.5mg mu maola 72; ndipo mlingo wa Cialis ukhale wotsika kuposa 10mg mu maola 72.

_Zotsatira:

_{Sciences la Gileadi. "Tybost (cobicistat) - MFUNDO ZONSE ZOKUTHANDIZA." Foster City, California; yafika pa February 3, 2015.}