Evotaz (atazanavir + cobicistat) - Uthenga wa mankhwala okhudza HIV

Kulemba

Evotaz (atazanavir + cobicistat) ndi mlingo wokhazikika womwe umagwiritsidwa ntchito pochiza HIV . Zigawo ziwiri za mankhwalawa zimagulitsidwa monga Reyataz (atazanavir) ndi Tybost (cobicistat) .

Mapangidwe a mapiritsi amodzi amathandiza kuti pakhale zosavuta, kamodzi, tsiku ndi tsiku, ndi chiwalo chothandizira kuti "kupititsa patsogolo" komanso kusunga atazanavir mu thupi.

Evotaz inavomerezedwa ndi US Food and Drug Administration (FDA) mu January 2015 kwa odwala achikulire atsopano omwe ali ndi HIV / 1.

Fomu

Phalasitiki yophimbidwa ndi filimu, yokhala ndi 300mg atazanavir ndi 150mg cobicistat, ndi yofiira ndi yofiira ndi nambala "3641" mbali imodzi.

Mlingo

Pulogalamu imodzi imatengedwa tsiku ndi tsiku ndi chakudya. Evotaz sichitha kugwiritsidwa ntchito yokha koma imayenera kutengedwa limodzi ndi mankhwala kapena mankhwala ochepetsa kachilombo ka HIV.

Malangizo

Asanayambe, odwala ayenera kuyesedwa kuti aone ngati zofuna zawo zapangidwe monga Evotaz zingawonongeke matenda a impso, makamaka pa odwala omwe amadziwika bwino kapena osadziwika bwino. Mukayang'aniridwa ndi Viread (tenofovir ) -madokotala omwe angayambitse matendawa, zimalimbikitsa kuti odwala ayesedwe kuti adziwe kuti ali ndi kachilombo ka mkodzo, mkodzo wamkodzo, ndi mapuloteni a mkodzo.

Tikulimbikitsanso kuti odwala omwe ali ndi matendawa, makamaka omwe ali ndi kachilombo koyambitsa matenda a HIV , apatsedwe kuyesedwa koyambitsa matenda asanayambe kuuzidwa kuti Evotaz.

Ngati kugonana kwa genotypic sikupezeka, Evotaz ayenera kupeŵa aliyense amene ali ndi kachilombo koyambitsa matenda a HIV protease.

Zotsatira Zogwirizana

Phunziro lachiwiri la anthu omwe amapita kuchipatala, zotsatira zowonjezereka za mankhwala zakhala zikudziwika pogwiritsa ntchito Evotaz. Zochitika zowonongeka kwambiri, zomwe zinafotokozedwa mwa 2% kapena zosakwana za odwala atsopano, anali:

• Jaundice (khungu la khungu ndi maso)
• Oter icterus (kutuluka kwa maso)
• Rash
• Nausea

Zotsatira zochepa zomwe zimagwiridwa ndi monga kutopa, kupweteka mutu, kusowa tulo, kusanza ndi ululu wamimba. Evneyz atayang'aniridwa ndi Viread (tenofovir), adatulukira miyala ya impso, ngakhale kuti milanduyi imatengedwa ngati yofatsa ndipo siidatengere mankhwala.

Kusiyanitsa Mankhwala

Evotaz sayenera kutengedwa ndi mankhwala awa:

• Mankhwala osokoneza bongo: Ranexa
• Mankhwala oletsa kugonana: Multaq
• Mankhwala a anti-cholesterol: Mevacor, Zocor
• Mankhwala a anti-gout: Uroxatral
• Mankhwala oletsa kuthamanga kwa magazi: Revatio
• Mankhwala a antipsychotic: Latuda, Orap
• Mankhwala a khansa: Camptosar, Campto
• Zosakaniza zotsutsana ndi migraine zotchedwa Ergot: DHE 45, Ergotrate, Hydergine, Migranal
• Mankhwala opatsirana pogwiritsa ntchito mankhwala a Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
• Zochitika: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
• Wotchedwa St. John's Wort

Kugonana kwa Mankhwala Opatsirana pogonana

Kugwiritsiridwa ntchito kwa Tybost ndi kutsatira mankhwala ochepetsa kachilombo ka HIV kungayambitse kapena kutaya mankhwala achikulire kapena kuwonjezeka kwa zotsatira zake:

• Crixivan (indinavir) sayenera kuyang'aniridwa ndi Evotaz.

• Intelence (etravirine) sayenera kuyang'aniridwa ndi Evotaz.
• Sustiva (efavirenz) sayenera kuyang'aniridwa ndi Evotaz.
• Viramune (nevirapine) sayenera kuyang'aniridwa ndi Evotaz.
• Mlingo wa Selzentry (maraviroc) uyenera kusinthidwa mpaka 150mg kawiri patsiku ngati udayang'aniridwa ndi Evotaz.

Zochita Zina Kapena Zoganizira

• Limbitsani dokotala wanu chilichonse chimene mukuganiza kuti chimakhalapo (figso) chomwe mungakhale nacho musanayambe Evotaz.
• Limbitsani dokotala wanu chilichonse chimene mukuganiza kuti chiwopsezo (chiwindi) chomwe mungakhale nacho musanayambe Evotaz, kuphatikizapo hepatitis A, hepatitis B kapena hepatitis C.
• Antacids ndi aluminium kapena magnesium hydroxide ingalepheretse Evotaz kuti itengeke bwino. Ngati mukugwiritsa ntchito mankhwala osokoneza bongo (mwachitsanzo, Rolaids, Tums, Milk wa Magnesia), akuuzidwa kuti atenge maola awiri kapena amodzi a Evotaz asanayambe kapena pambuyo pake.

• H ₂ - omwe amatsutsana nawo amaletsa m'mimba asidi (mwachitsanzo, Tagamet, Pepcid, Axid, Zantac) amatha kulepheretsanso kuyamwa kwa Evotaz. Zimalangizidwa kuti azitengedwa ndi Evotaz kapena, mwachindunji, maola 10 asanafike kapena pambuyo pa mlingo wa Evotaz.
• Proton pump inhibitors (mwachitsanzo, Losec, Prilosec, Prevacid, Nexium, Pariet) amatha kulepheretsa Evotaz kukonda. Amaperekedwa kuti atenge maola 12 musanafike kapena pambuyo pa mlingo wa Evotaz.
• Mankhwala ochepetsa kupweteka kwa Erectile (Viagra, Levitra, Cialis) ayenera kugwiritsidwa ntchito mosamala pamene Evotaz ingalimbikitse kuchuluka kwa mavuto, kuphatikizapo kusokonezeka kwa maso, hypotension, ndi priapism (zopweteka, zosautsa). Ndikoyenera kuti Viyeza ya kuchepa imachepetsedwe osapitirira 25mg mu maora 48; Mlingo wa Levitra ukhale wocheperapo mpaka 2.5mg mu maola 72; ndipo mlingo wa Cialis ukhale wotsika kuposa 10mg mu maola 72.
• Pa nthawi yokhala ndi mimba, Evotaz sayenera kulamulidwa pa nthawi yachiwiri kapena itatu yachitatu, ngati wodwala ali ndi kachilombo ka HIV kapena Viread (tenofovir) ngati pangakhale chiopsezo cha kernicterus (zovuta zomwe zimachitika kwa ana obadwa kumene mliri wakuda).

_Zotsatira:

_{Bristol-Myers Squibb. "Evotaz (Atazanvir + cobicistat) - MFUNDO ZONSE ZOKUTHANDIZA." New York, New York; yafika pa February 3, 2015.}