Prezcobix (darunavir + cobicistat) ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza HIV . Zida ziwiri zomwe zili mu Prezcobix zimagulitsidwa pa Prezista (darunavir) ndi Tybost (cobicistat) .
Piritsi imodzi, mapulogalamu omwe amapanga mapulogalamuwa amathandiza mosavuta, kamodzi, tsiku ndi tsiku, ndi mankhwala omwe amachititsa kuti thupi lizikhala bwino.
Prezcobix inavomerezedwa ndi US Food and Drug Administration (FDA) mu January 2015 kwa odwala achikulire atsopano omwe ali ndi HIV / 1.
Fomu
Pulogalamu yamakina yofiira, yomwe ili ndi 800mg ya darunavir ndi 150mg ya cobicistat, ndi ya pinki yomwe ili ndi "TG" mbali imodzi ndi "800" pambali inayo.
Mlingo
Pulogalamu imodzi imatengedwa tsiku ndi tsiku ndi chakudya. Prezcobix sichitha kugwiritsidwa ntchito yokha koma imayenera kutengedwa limodzi ndi mankhwala kapena mankhwala ochepetsa kachilombo ka HIV.
Malangizo
Asanayambe, odwala ayenera kuyesedwa kuti aone ngati chiwerengero cha Prezcobix chimawoneka kuti chingawonongeke matenda a impso, makamaka pa odwala omwe amadziwika bwino kapena osadziwika kuti alibe mphamvu. Poyendetsedwa ndi Viread (tenofovir) - mankhwala omwe amadziwikiranso kuti amachititsa kuti thupi likhale lopweteka, zimalimbikitsidwa kuti odwala ayesedwe kuti adziwe kuti ali ndi kachilombo ka mkodzo, mkodzo wa m'kodzo, ndi mapuloteni a mkodzo.
Tiyeneranso kuti odwala omwe ali ndi kachilombo ka HIV , makamaka omwe ali ndi kachilombo koyambitsa matenda a HIV , athandizidwe kuyeza ma ARV asanayambe kumwa Prezcobix. Ngati kupima kwa genotypic sikupezeka, Prezcobix ayenera kupeŵa aliyense yemwe ali ndi kachilombo koyambitsa matenda a HIV protease.
Zotsatira Zogwirizana
Phunziro lachitatu la maphunziro a anthu, zotsatira za mankhwala osokoneza bongo zakhala zikudziwika pogwiritsira ntchito Prezcobix. Zochitika zovuta kwambiri, zomwe zimafotokozedwa mwa odwala 5% kapena osachepera, zinali:
- Kutsekula m'mimba
- Nausea
- Rash
- Mutu
- Kupweteka m'mimba
- Kuthamanga
Kusiyanitsa Mankhwala
Prezcobix sayenera kutengedwa ndi mankhwala awa:
- Mankhwala osokoneza bongo: Ranexa
- Mankhwala oletsa kugonana: Multaq
- Mankhwala a anti-cholesterol: Mevacor, Zocor
- Mankhwala a anti-gout: Uroxatral
- Mankhwala oletsa kuthamanga kwa magazi: Revatio
- Mankhwala a antipsychotic: Latuda, Orap
- Mankhwala a khansa: Camptosar, Campto
- Zosakaniza zotsutsana ndi migraine zotchedwa Ergot: DHE 45, Ergotrate, Hydergine, Migranal
- Mankhwala opatsirana pogwiritsa ntchito mankhwala a Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Zochitika: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- Wotchedwa St. John's Wort
Kugonana kwa Mankhwala Opatsirana pogonana
Kugwiritsira ntchito Prezcobix ndi mankhwala otsatirawa omwe angatengere kachilombo ka HIV kungapangitse kapena kutayika kwa mankhwala ozunguza bongo kapena kuopsa kwa zotsatira zake:
- Crixivan (indinavir) sayenera kuyang'aniridwa ndi Prezcobix.
- Videx (didanosine) iyenera kutengedwa ola limodzi kapena ola limodzi mutatha kutenga Prezcobix.
- Intelence (etravirine) sayenera kuyang'aniridwa ndi Prezcobix.
- Viramune (nevirapine) sayenera kuyang'aniridwa ndi Prezcobix
- Mlingo wa Selzentry (maraviroc) uyenera kusinthidwa kufika 150mg kawiri patsiku ngati udalamulidwa ndi Prezcobix.
Zochita Zina Kapena Zoganizira
- Limbitsani dokotala wanu chilichonse chomwe mukuchidziŵa kapena chodziwika kuti muli ndi impso musanayambe Prezcobix.
- Mankhwala ochepetsa matenda a Erectile (Viagra, Levitra, Cialis) ayenera kugwiritsidwa ntchito mosamala ngati chigoba cha Prezcobix chikhoza kulimbikitsa mavuto, kuphatikizapo kusokonezeka kwa maso, hypotension, ndi priapism (zopweteka, zosavuta). Ndikoyenera kuti Viagra ya kuchepa imachepetsedwe kupitirira 25mg mu maora 48; Mlingo wa Levitra umachepetsedwa osapitirira 2.5mg mu maola 72, ndipo mlingo wa Cialis umachepetsedwa osapitirira 10mg mu maola 72.
Zotsatira:
Bristol-Myers Squibb. "PREZCOBIX - KUDZIWA ZONSE ZOKUTHANDIZA." New York, New York