Genvoya ndi piritsi limodzi, mankhwala osakaniza omwe amagwiritsidwa ntchito pochiza HIV, yomwe ili ndi mankhwala anayi ochepetsa ma ARV :
- Elvitegravir , integrase inhibitor
- Cobicistat , mankhwala osokoneza bongo a HIV
- Emtricitabine, nucleotide reverse transcriptase inhibitor (NtRTI)
- Tenofovir alafenamide (TAF), wina NtrTI
Genvoya ndilo piritsi loyamba lophatikizira kuti ligwiritse ntchito TAF, "njira yabwino" ya tenofovir disoproxil fumarate (TDF) yomwe imapezeka mu mankhwala Truvada, Atripla , ndi Complera.
Zoterezi, zikhoza kuonedwa ngati zowonjezereka pa Stribild , kupanga mapepala omwe ali ndi elvitegravir + cobicistat + emtricitabine + TDF.
TAF imaonedwa kuti ndi yopambana ndi TDF chifukwa imatha kupereka mankhwala othandizira kwambiri ku maselo ndi mankhwala ochepa kwambiri-kutanthawuza kuti pali mankhwala ochepa omwe amapezeka m'magazi komanso mwayi wambiri wopanga impso zokhudzana ndi mankhwala. toxicities.
(Ngakhale kuti chiopsezo cha tizilombo toyambitsa matenda a TDF chimaonedwa kuti n'chochepa m'mayiko otukuka, chiwopsezochi chimaoneka kuti chimawonjezeka kwambiri m'mayiko osauka kumene kuli chiwopsezo chachikulu cha matenda osokonezeka a impso.)
Chithandizo Chachidziwitso
Genvoya inavomerezedwa ndi US Food and Drug Administration pa November 5, 2015, kuti agwiritsidwe ntchito kwa akuluakulu ndi ana opitirira zaka khumi ndi ziwiri omwe sanayambe kukhala ndi kachilombo ka HIV ndi kulemera makilogalamu 35. Amavomerezedwanso kwa anthu akuluakulu pa chithandizo chomwe chili ndi mphamvu yowonongeka (yosadziwika).
Kupanga
Genvoya ndi piritsi yobiriwira, yofiira, yomwe ili ndi 150mg ya elvitegravir, 150mg ya cobicistat, 200mg ya emtricitabine ndi 10mg ya TAF. Ili ndi "GSI" mbali imodzi ndipo ili ndi "510" pamzake.
Mlingo
Pulogalamu imodzi imatengedwa tsiku ndi tsiku ndi chakudya. Genvoya sayenera kutengedwa ndi mankhwala ena oletsa kachilombo ka HIV omwe amagwiritsidwa ntchito pochiza HIV.
Zotsatira Zotsatira
Zotsatira zochepa za mankhwala zakhala zikudziwika mu odwala omwe akuyesa matenda a Genvoya. Zochitika zovuta kwambiri, zomwe zimafotokozedwa mwa odwala 5 kapena oposa, ndi:
- Nausea
- Kutsekula m'mimba
- Kutopa
- Mutu
Zotsatira zake zinkatha nthawi yayitali, kuthetsa pa masabata awiri, ndipo odwala ochepa amasiya chifukwa cha kusagwirizana kwa mankhwala.
Contraindications
Genvoya sayenera kutengedwa ndi mankhwala awa kapena mankhwala owonjezera:
Mankhwala oletsa anti-migraine: Cafergot, Migergot, Ergostat, Ergotamine ya Medihaler, Wigraine, Wigrettes, Ergotrate, Methergine, DHE 45
- Mankhwala otsutsa-psychotic: Orap
- Cholesterol-kuchepetsa mankhwala a statin: Zocor, Simcor, Vytorin, Mevacor, Advicor, Altoprev, Mevacor
- Mankhwala a Hepatitis B: Hepsera, Preveon
- Prokinetic agents: Propulsid, Propulsid Quicksolv
- Mankhwala a prostatu: Uroxatral
- Mankhwala osokoneza bongo: Revatio
- Mankhwala oletsa chifuwa chachikulu: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Zochitika: Kunena, Halcion
- Wotchedwa St. John's Wort
Mfundo Zina
Genvoya sivomerezedwa kwa odwala omwe ali ndi vuto la impso (lomwe limatanthauzidwa kuti ali ndi chidziwitso chopangidwa ndi creatinine osachepera 30mL pa mphindi). Chonde funsani dokotala wanu ngati mwakhala kapena mukuchiritsidwa ndi matenda ena a impso ndi dokotala wina.
Genvoya sali ovomerezeka kwa odwala matenda a chiwindi kapena omwe ali ndi matenda aakulu a chiwindi (hepatitis B) (HBV) chifukwa angathe kuwonjezera mavuto a chiwindi. Amalangizidwa kuti anthu omwe ali ndi HIV ayang'anire HBV asanafotokoze Genvoya. Chonde dulani dokotala wanu ngati muli ndi vuto la chiwindi ndi / kapena mbiri ya chiwindi.
Zotsatira:
US Food and Drug Administration. "FDA ikuvomereza mankhwala atsopano a HIV." Silver Spring, Maryland; ndondomeko yofalitsa yomwe yatulutsidwa pa November 5, 2015.
Sciences la Gileadi. "Genvoya - Mfundo zazikulu zofotokozera." Foster City, California