Vitekta (elvitegravir) - Chidziwitso cha mankhwala a HIV

Mankhwala Amateteza HIV kuti iwononge Mitundu ya Genetic

Kulemba

Vitekta (elvitegravir) ndi mankhwala opatsirana pogonana omwe amadziwika ngati integrase inhibitor omwe amagwiritsidwa ntchito pochiza HIV . Integrase inhibitors amagwira ntchito potseka kachilombo ka HIV kamene imatchedwa integrase, yomwe kachilombo ka HIV kamagwiritsira ntchito kulemba ma coding m'kati mwa DNA. Mwa kulepheretsa integrase, kachilomboka sikhoza kumaliza moyo wake ndikupanga ma viriyoni ena.

Vitekta inavomerezedwa ndi US Food and Drug Administration (FDA) mu September 2014 kuti agwiritsidwe ntchito kwa akuluakulu omwe kale anali ndi kachilombo ka HIV.

Elvitegravir ndi chigawo chokhazikika cha mlingo wa mankhwala Stribild (amene amadziwikanso kuti "Quad Pill") komanso mtundu wachiwiri wa Stribild wotchedwa Genvoya .

Kupanga Mankhwala

Vitekta ilipo papepala ziwiri:

• Pulogalamu ya 85 mg yozungulira, yofiira mafilimu, yobiriwira ndi "GSI" pambali imodzi ndi "85" pambali inayo.
• Pepala lokhala ndi mafilimu 150 mg, lopangidwa ndi filimu, lobiriwira ndi "GSI" pambali imodzi ndi "150" pambali inayo.

Mlingo

Vitekta nthawi zonse iyenera kugwiritsidwa ntchito pamodzi ndi kachilombo koyambitsa matenda a HIV protease inhibitor (PI) ndi Norvir (ritonavir) , omwe amagwiritsa ntchito mankhwala owonjezera omwe amachititsa kuti mankhwalawa akhale ochepa. Vitekta ayenera kutengedwa ndi chakudya.

Mlingo wovomerezeka ukusiyana ndi kusankha mankhwala motere:

Zotsatira Zogwirizana

Phunziro lachiwiri la anthu omwe amapita ku Vitekta, zotsatira zingapo zowononga mankhwalawa zakhala zikudziwika. Zochitika zowonjezereka kwambiri, zomwe zimawerengedwa ndi ocheperapo 2% mwa omwe akuyesa nawo ndi awa:

• Kutsekula m'mimba
• Nausea
• Mutu

Zotsatira zochepa zomwe zimafala zimaphatikizapo ululu wamimba, indigestion, kuthamanga, kutopa ndi kusanza.Zotsatira zotsatira zakhala zochepa, ndipo odwala ochepa sasiya chifukwa cha kusasalana.

Kusiyanitsa Mankhwala

Vitekta sayenera kutengedwa ndi mankhwala awa:

• Mankhwala a Hepatitis C: Invicek, Victrelis
• Mankhwala opatsirana pogwiritsa ntchito mankhwala a Rifampin: Rifater, Rifamate, Rimactane, Rifadin, Priftin (m'malo mwa Mycobutin)
• Wotchedwa St. John's Wort

Nthawi zonse muziwauza adokotala za mankhwala alionse kapena othandizira ena, omwe amawalamula kapena osapatsidwa, kuti mutengepo musanayambe mankhwala alionse ochepetsa kachilombo ka HIV.

Kugonana kwa Mankhwala Opatsirana pogonana

Kugwiritsidwa ntchito kwa Vitekta ndi mankhwala ochepetsa kachilombo ka HIV kumapangitsa kuti pakhale kutaya kwa mankhwala omwe akutsatira kapena kuwonjezeka kwa zotsatira zake:

• Sustiva (efavirenz) sayenera kuyendetsedwa ndi Vitetkta.
• Viramune (nevirapine) sayenera kuyang'aniridwa ndi Vitekta.
• Videx (didanosine) iyenera kutengedwa ora limodzi pasanafike maola awiri pambuyo pa Vitekta mlingo.

• Mtundu wotchedwa tybost (cobicistat), wothandizira kwambiri ngati Norvir, sayenera kutengedwa ndi Vitekta pamene akuyang'aniridwa ndi protease inhibitor.

Mfundo Zina

Antacids ikhoza kuteteza Vitekta kukhala yosakwanira. Ngati mukugwiritsa ntchito anti-acid antibiotic (mwachitsanzo, Rolaids, Tums, Milk of Magnesia), akuuzidwa kuti atenge maola awiri kapena amodzi a Evotaz maola awiri kapena awiri.

Akazi ayenera kulangiza dokotala wawo ngati akulandira kapena akukonzekera kumwa mankhwala oletsa kubereka. Vitekta, akagwiritsidwa ntchito ndi Norvir, ikhoza kuchepetsa kwambiri majekeseni a plasma a ethinyl estradiol / norgestimate hormonal contraceptive.

Njira zina zothandizira kubereka ndizovomerezeka. Musayambe kuchulukitsa mankhwala osokoneza bongo. Amalangizidwa kuti amayi oyamwitsa asamwetse ngati ali ndi kachilombo ka HIV pamene angatenge kachilombo kwa mwanayo.

Vitekta ili ndi lactose kotero onetsetsani kulangiza dokotala wanu ngati muli ndi lactose osagwirizana.

_Zotsatira:

_{US Food and Drug Administration (FDA). " VITEKTA - MFUNDO ZONSE ZOKUTHANDIZA." Srrring Silver, Maryland; yafika pa February 3, 2015.}

_{FDA. "FDA imavomereza mapiritsi atsopano ogwiritsira ntchito kachilombo ka HIV kwa odwala ena." Silver Spring, Maryland; ndondomeko yotulutsidwa pa August 27, 2012.}

_{Sciences la Gileadi. " Genvoya - Mfundo zazikulu zofotokozera." Foster City, California; inapezeka pa December 14, 2015.}