Mgwirizano Wowonjezereka Mankhwala Amapereka Zochepa Zochepa
Kulemba
Odefsey ndi piritsi limodzi, mankhwala osakaniza omwe amagwiritsidwa ntchito pochiza HIV, omwe ali ndi ma antiretroviral atatu osiyanasiyana:
- rilpivirine , osati nucleoside reverse transcriptase inhibitor (NNRTI)
- emtricitabine, nucleotide reverse transcriptase inhibitor (NtrTI)
- tenofovir alafenamide (TAF) , wina NtRTI
Odefsey ndichiwiri mankhwala osakaniza kuti agwiritse ntchito TAF, "njira yabwino" ya tenofovir disoproxil fumarate (TDF) yomwe imapezeka mankhwala a Truvada ndi Atripla .
Zoterezi, zikhoza kuonedwa ngati kusintha kwa Complera, kupanga mapepala amodzi omwe ali ndi rilpivirine + emtricitabine + TDF.
TAF amaonedwa kuti ndi wamkulu kuposa TDF chifukwa amatha kupereka mankhwala ogwira ntchito mosavuta ku maselo ndi pang'ono zochepa-kutanthauza kuti pali mankhwala ochepa omwe amapezeka m'magazi komanso mwayi wochepa wa mankhwala ozunguza ubongo a impso.
(Ngakhale kuti chiopsezo cha tizilombo toyambitsa matenda a TDF chimaonedwa kuti n'chochepa m'mayiko otukuka, chiwopsezochi chimaoneka kuti chimawonjezeka kwambiri m'mayiko osauka kumene kuli chiwopsezo chachikulu cha matenda osokonezeka a impso.)
Chithandizo Chachidziwitso
Odefsey inavomerezedwa ndi US Food and Drug Administration pa March 1, 2016 kuti agwiritsidwe ntchito kwa akuluakulu ndi ana opitirira zaka khumi ndi ziwiri omwe sanakhalepo ndi kachilombo ka HIV , omwe ali ndi chiwerengero cha tizilombo 100,000 / m kapena pansi, Ndilo mapaundi 77 (35kg) kapena kuposa.
Odefsey angagwiritsenso ntchito m'malo mwa mankhwala omwe alipo panopa (monga a Complera) ngati wodwalayo ali ndi chiwerengero chosatulutsa mphamvu (<50 maselo / mL) kwa miyezi isanu ndi umodzi, alibe mbiri ya kuchepa kwa mankhwala, ndipo sadziwa Kukaniza mankhwala ena alionse ku Odefsey.
Kupanga
Odefsey ndi piritsi yofiira, yofiira, yomwe imakhala ndi 25mg ya rilpivirine, 200mg ya emtricitabine ndi 25 mg ya TAF.
Ili ndi "GSI" mbali imodzi ndipo ili ndi "255" pambali inayo.
Mlingo
Phale limodzi tsiku ndi tsiku amatengedwa ndi chakudya. Odefsey sayenera kutengedwera ndi mankhwala ena opatsirana pogonana omwe amagwiritsidwa ntchito pochiza HIV.
Zotsatira Zotsatira
Zotsatira zoopsa za mankhwala zakhala zikudziwika mu mayesero a zamankhwala omwe akudwala rilpivirine ndi / kapena emtricitabine + TAF, omwe ambiri mwa iwo anali:
- Nausea
- Mutu
- Kusagona
- Kusokonezeka maganizo
Zotsatira zake zimakhala zochepa, ndipo odwala ochepa amasiya chifukwa cha kusalana.
Contraindications
Odefsey sayenera kutengedwa ndi mankhwala awa kapena mankhwala owonjezera:
- Mankhwala osokoneza bongo: Tegretol, Trilepta, phenobarbital, phenytoin
- Mankhwala oletsa chifuwa chachikulu: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Proton pump inhibitors (PPIs): Nexium, Kapidex, Dexilant, Prevacid, Losec, Prilosec, Protonix, Aciphex kapena PPI ina iliyonse
- Mankhwala a steroid: dexamethasone (ngakhale angaperekedwe pa mlingo umodzi, ngati mankhwala amasonyeza)
- Wotchedwa St. John's Wort
Nthawi zonse muziwauza adokotala za mankhwala alionse kapena othandizira ena, omwe amawalamula kapena osapatsidwa, kuti mutengepo musanayambe mankhwala alionse ochepetsa kachilombo ka HIV.
Mfundo Zina
Odefsey savomerezedwa kwa odwala omwe ali ndi vuto la impso (lomwe limatanthauzidwa kuti ali ndi chidziwitso chopangidwa ndi zomera zopitirira 30mL mphindi).
Chonde funsani dokotala wanu ngati mwakhala kapena mukuchiritsidwa ndi matenda ena a impso ndi dokotala wina.
Odefsey sakuvomerezeka kwa odwala matenda a chiwindi kapena omwe ali ndi matenda aakulu a chiwindi (hepatitis B) (HBV) chifukwa angathe kuwonjezera mavuto a chiwindi. Amalangizidwa kuti anthu omwe ali ndi HIV ayang'anire HBV asanafotokoze Odefsey. Chonde dulani dokotala wanu ngati muli ndi vuto la chiwindi ndi / kapena mbiri ya chiwindi cha chiwindi.
Chigawo cha rilpivirine cha Odefsy chikhoza kuyambitsa hypersensitivity reaction mwa ochepa odwala, kawirikawiri monga kutukumuka, kutupa maso (maso a pinki), kutupa kwa nkhope, malungo, kapena mayankho ena.
Kawirikawiri, kusintha kwa hypersensitivity kumakhala masabata 1-6 pambuyo pa kuyamba kwa mankhwala. Limbitsani dokotala mwamsanga za zizindikiro zoterezi zikuwonekera. Pa milandu yoopsa, mankhwalawa amafunika kuti asiye.
Zotsatira:
Reuters. "KUKHALA - Scientific Sciences Giliyadi Inati US FDA Amavomereza Odefsey." Zatulutsidwa pa 1 March, 2015.
Sciences la Gileadi. " Odefsey - Mfundo Zapamwamba Zopereka Mauthenga." Foster City, California; inapezeka pa March 18, 2016.