Kugwiritsa Ntchito Mankhwala, Maganizo, ndi Contraindications
Epzicom ndi mankhwala omwe amagwiritsidwa ntchito pochiza HIV, omwe ali ndi ma antiretroviral awiri, abacavir (Ziagen) plus lamivudine (Epivir). Mankhwalawa amadziwika kuti nucleoside reverse transcriptase inhibitors (NRTIs) ndipo amagwira ntchito poletsa ma enzyme kuti athetse chiwerengero cha tizilombo toyambitsa matenda m'thupi.
Pochita zimenezi, kachilombo ka HIV silingathe kufalikira ndikufalikira ku maselo ena.
Epzicom inavomerezedwa kuti igwiritsidwe ntchito kwa akuluakulu ndi US Food and Drug Administration (FDA) pa August 2, 2004. Kunja kwa US, mankhwalawa amagulitsidwa pansi pa dzina la malonda Kivexa .
Kupanga Mankhwala
Epzicom ilipo mu mawonekedwe apiritsi ndi 600mg ya abacavir ndi 300mg ya lamivudine. Mapiritsi ophimbidwa ndi mafilimu ali ozungulira, olanje, ndipo ali ndi "GS FC2" mbali imodzi.
Mlingo
Phale limodzi tsiku ndi tsiku limatengedwa pamlomo kapena popanda chakudya. Epzicom sichitengedwera payekha ndipo iyenera kugwiritsidwa ntchito pogwiritsa ntchito mankhwala limodzi ndi mankhwala ena opatsirana pogonana.
Zotsatira Zogwirizana
Zotsatira zambiri zomwe zimagwirizanitsidwa ndi ntchito ya Epzicom (yomwe imachitika mpaka 9%) imaphatikizapo:
- Mankhwala osokoneza bongo ( onani m'munsimu )
- Kusagona
- Kusokonezeka maganizo
- Mutu / migraine
- Chizungulire
- Nausea
- Kutsekula m'mimba
- Rash
- Fever
- Kupweteka m'mimba
Zizindikiro zambiri zimakhala zochepa ngakhale kuti anthu omwe ali ndi zizindikiro za mankhwala osokoneza bongo ayenera kufunafuna chithandizo chamankhwala mwamsanga.
Warning Hypersensitivity Warning
Nthaŵi zina mankhwala osokoneza bongo amagwiritsidwa ntchito kwa odwala omwe ali ndi mankhwala ozunguza bongo ndi abacavir ndipo angathe kupha ngati sakusamalidwa. Amadziwika ndi zigawo zisanu zotsatirazi:
- Fever
- Rash
- Matenda a m'mimba (kunyowa, kutsekula m'mimba, kusanza, kupweteka m'mimba)
- Kutopa, malaise, kutopa, kupweteka pamtima / mgwirizano
- Zizindikiro za kupuma (kuthamanga kwadzidzidzi, kupuma pang'ono, kupweteka)
Zizindikiro za hypersensitivity zimawoneka mkati mwa masabata asanu ndi limodzi oyambirira a kutsekula, ngakhale kuti zitha kuoneka pa nthawi iliyonse ya mankhwala osokoneza bongo. Komabe, nthawi zambiri, zizindikiro zambiri za hypersensitivity zimachitika masiku khumi oyambirira kapena apo.
Ngati munthu akuganiza kuti hypersensitivity, Epzicom ayenera kuimitsidwa mwamsanga . Odwala ayenera kupita nthawi yomweyo kukaonana ndi dokotala wawo / kapena kupita kuchipatala chapafupi kapena zipinda zam'tsogolo mwamsanga.
Asanayambe kulandira mankhwala kwa abacavir, madokotala akulangizidwa kuti awonetsere kuti HLA-B * 5701 alipo ngati odwala omwe ali ndi chibadwachi amadziwika kuti ali pangozi yaikulu ya abacavir hypersensitivity.
Kafukufuku wamakono awonetsetsa kuti pafupifupi 8% mwa odwala pa abacavir adzalandira chithandizo chamagetsi, nthawi zina zovuta.
Contraindications
- Poyamba ma hypersensitivity a abacavir: Odwala omwe ali ndi ma hypersensitivity aperekedwa kwa (Ziagen) abacavir sayenera kuuzidwa Epzicom.
- Kuwonongeka kwa chiwindi: Odwala omwe ali ndi vuto la chiwindi (hepatic (infirmity) ayenera kupewa Epzicom. Chonde dalitsani dokotala ngati muli ndi vuto la chiwindi, kapena ngati mwadwala (kapena mukuganiza kuti mwakhala ndi kachilomboka) ndi matenda a hepatitis A, hepatitis B, kapena hepatitis C. Kuwonjezeka kwakukulu kwa matenda a hepatitis B kwakhala odwala omwe ali ndi kachilombo ka HIV, pamene odwala ena omwe ali ndi matenda a hepatitis C omwe ali ndi interferon ndi / kapena ribavirin akhoza kukhala ndi zizindikiro zowonjezereka.
Kuyanjana kwa Mankhwala
- Ethanol (kumwa mowa): amachepetsa kuthetsa abacavir ku dongosolo
- Methadone (yogwiritsira ntchito mankhwala osokoneza bongo): amachepetsa mphamvu ya methadone pang'onopang'ono wodwala
Amalangizidwa kuti odwala amwe mowa pa Epzicom, pamene odwala pa methadone ayenera kulangiza dokotala ngati Epzicom atchulidwa.
Zotsatira za Chithandizo
Odwala omwe ali ndi vuto laimpso (impso) sayenera kuuzidwa Epzicom ngati chilolezo cha creatinine chiri pansi pa 50mL / mphindi. Odwala omwe ali ndi chiopsezo chotaya matendawa, awonetseni kuti chilengedwe chimakhala bwino, serum phosphorous, mkodzo wa m'madzi komanso mapuloteni a mkodzo pamene mukuyesa kufufuza nthawi zonse .
Ngakhale maphunziro ena a zinyama asonyeza kuti chiopsezo chowonjezereka cha abambo omwe ali ndi makoswe ndi akalulu omwe amadziwika ndi abacavir kapena lamivudine, palibe kusiyana kotereku komwe kwadziwika kuti ali ndi amayi omwe ali ndi pakati omwe akupezeka ndi mankhwalawa.
M'mayiko otukuka, ndibwino kuti amayi omwe ali ndi kachilombo ka HIV asapewe kuyamwa chifukwa cha kuopsa kofalitsa HIV kwa ana awo.
Zotsatira:
US Food and Drug Administration (FDA). "FDA imavomereza Mgwirizano Wosakaniza Madzi Awiri Mankhwala Ogwiritsa Ntchito Mankhwala Omwe Amachiza Chitetezo cha HIV-1." Silver Spring, Maryland; adatulutsidwa pa August 2, 2004.