Ochita Kafukufuku Akufuna "Kupha" HIV Popanda Malo Ake
Mavitamini apamtundu ndi maselo a thupi limene kachilombo ka HIV kamabisala (kapena "kupitiriza") ngakhale pakuyang'aniridwa ndi mankhwala opatsirana pogonana . Zipinda zamakonozi zimapezeka m'magulu ambirimbiri a ziwalo, kuphatikizapo ubongo, minofu ya lymphoid, fupa la fupa komanso chiwalo chogonana.
M'dziko lawo lachilendo (kapena "proviral" ), kachilombo ka HIV kangaphatikizepo ma genealo ake mu DNA ya selo yambiri, koma m'malo mopha, imangowonjezera pamodzi ndi wolandira.
Mosiyana ndi kachilombo koyambitsa, maselo obisikawa sangazindikire ndi chitetezo cha thupi. M'malomwake, majeremusi amtunduwu amachokera ku mibadwomibadwo, yokhoza kubwezeretsanso chifukwa cha kugwa kwa chitetezo cha mthupi.
Ndipotu, chitetezo cha m'thupi chimapereka kachilombo ka HIV. Pamene chitetezo cha mthupi chitayikidwa pamaso pa kachirombo ka HIV, thupi lidzapanga CD4 T-maselo omwe, mochititsa chidwi, ndiwo omwe akuwunikira kwambiri. Maselo omwe ali ndi kachilombo ka HIV adzakula, kupanga maselo ambiri omwe ali ndi kachilombo ka HIV ndikulitsa chitsime cha tizilombo.
Ndiko kulimbikira kwa mavairasi obisika omwe akupitirizabe kulephera kuyesetsa kuchiza matendawa.
Ndondomeko Zowonongeka Zakumapeto Zosachedwa
Chovuta chachikulu chomwe ochita kafukufuku akukumana nacho lero ndicho kupeza njira zomwe angayambitsire ndi kuteteza kachilombo ka HIV m'mabwalo ake, ndikusiya njira zowonongeka .
Ngakhale kuti ART imatha kuthetsa mabotolowa pakapita nthawi, imachita pang'onopang'ono. Masamu a masamu asonyeza kuti zingatenge zaka pakati pa 60 ndi 80 kuti zithetsedwe.
Owonjezereka akuyang'ana kugwiritsa ntchito mankhwala ena omwe amawoneka kuti amachititsa kuti HIV isayambe.
Ena mwa iwo ndi oimira otchedwa HDAC inhibitors, omwe akhala akugwiritsidwa ntchito mobwerezabwereza monga zowonongeka komanso anti-epileptics.
Ndipo ngakhale pakhala pali kupambana pa kukhazikitsa kachilombo koyambitsa matenda a HIV, asayansi sadziwa ngakhale kuti zidazi ndi zazikulu kapena maselo ena angapatse HIV malo obisika. Choncho, n'kosatheka kudziwa ngati mabungwe amenewa athandizidwadi ndi mankhwalawa.
Kafukufuku waposachedwapa, wasonyeza kuti ngakhale kuti mankhwala ena a HDAC oletsa tizilombo toyambitsa matenda ali ndi mphamvu zotsegula kachilombo koyambitsa matendawa, palibe umboni weniweni wakuti kutsegulira koteroko kwachepetsa kukula kwa magome.
Asayansi ena, panthawiyi, amafunsa ngati "kukankha" kachilombo ka HIV m'madzi ake kudzakhala kokwanira kuthetsa. Zotsatira zake, magulu angapo ofufuzira amafufuza omwe amawoneka kuti angathe kupha kachilombo kamene kamasulidwa kumene ali ndi poizoni ochepa. Pakati pa anthu otchuka kwambiri ndi acitretin, mawonekedwe a vitamini A panopa amagwiritsidwa ntchito pochiza psoriasis yoopsa mwa akuluakulu.
Zotsatira za Kukhazikika Kwambiri
Chinthu chimodzi chokhumudwitsa kwambiri cha tizilombo toyambitsa matenda ndi chakuti, ngakhale panthawi yake, kukhalapo kwa HIV m'kati mwa maselo kumayambitsa yankho lopweteka lopitirira. Ngakhalenso ngati munthu ali ndi kachilombo koyambitsa matenda a HIV ndipo amatha kukhalabe ndi chiwerengero cha mavairasi osadziwika , kutukuka kwapansiku kumapangitsa kuti maselo ndi matenda asinthe, mofulumizitsa ukalamba.
Njirayi, yotchedwa senescence , isanafike nthawi yomwe anthu omwe ali ndi kachilombo ka HIV nthawi yayitali ali ndi chiwopsezo cha khansa, matenda a mtima, kufooka kwa mafupa, ndi matenda osokoneza bongo-ndipo nthawi zambiri zaka 10 mpaka 15 zisanachitike kuposa zomwe zingatheke anthu.
Zotsatira:
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Søgaard, O .; Graverson, M .; Leth, S .; et al. " HDAC inhibitor romidepsin imasintha kachilombo ka HIV-1 mu vivo monga momwe imawerengedwera ndi mayendedwe owonetsera." Msonkhano wa 20 wa AIDS; July 22, 2014; Melbourne, Australia; chosamveka TUAA0106LB.
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Peilin, L .; Kaiser, P .; Lampris, H .; et al. "Kupititsa patsogolo njira ya RIG-1 kuti iphe maselo m'mabotolo omwe akutsata pambuyo poyambitsa mavairasi." Nature Medicine. June 13, 2016; 22: 807-8-11.