Matenda ambiri okalamba anawona zaka 10 mpaka 15 zisanachitike
Kutenga kachilombo ka HIV kumakhala ndi mphamvu yowonongeka kwa nthawi yaitali, yomwe thupi limayankha kupezeka kwa kachilomboka popanga mapuloteni oteteza thupi komanso mapuloteni oteteza thupi. Kuwonjezeka kwa chitetezo cha mthupi ndi kupitiriza, kutentha kwakukulu komwe kumayambitsidwa ndi kachirombo ka HIV kumatengedwa kuti ndi ovuta kwambiri pa ukalamba, zomwe zimayambitsa matenda oyamba msinkhu komanso matenda okalamba.
Njira yofulumira imeneyi imatchulidwa kuti senescence msanga .
Kufotokozera Kulamba ndi Kusakalamba Kwakale
Kusintha kwa chiberekero kumatanthauzidwa ngati kukalamba kwa munthu kapena thupi panthawi yochepa kwambiri kuposa momwe ankayembekezera kapena anthu ambiri.
Kuyankhula moyenera, ukalamba umakhala wochepa chifukwa thupi limachepa kuthana ndi zovuta, zomwe zimapangitsa kuti zikhale zovuta kusunga stasis (equilibrium), poonjezera chiopsezo cha matenda okalamba monga matenda a Alzheimer's or bones. Kutentha kwa msinkhu kumatanthawuza kuti thupi likukalamba bwino nthawi yake isanakwane ndipo kawirikawiri limagwirizanitsidwa ndi amodzi kapena angapo ang'onoting'ono kapena zochitika.
Kukalamba kawirikawiri kumagwirizanitsa ndi kutupa kosatha, komwe kumatchedwa inflammaging -yomwe imathandiza kuchepetsa kukula kwa maselo, komanso kuwonongeka kwa minofu. Mankhwala a ukalamba amalingaliridwa, ambiri, osapeĊµeka, ngakhale kuti majini, chilengedwe ndi zokhudzana ndi zaka zingathe kudziwa kuti munthu akhoza kuvutika ndi ukalamba ndi imfa.
Mosiyana ndi zimenezi, kutentha kwa msanga kumayambitsidwa ndi kutupa kwakukulu komwe kuli kwakukulu kuposa munthu wathanzi, wathanzi. Kuchuluka kwa kutukuka kosalekeza kumeneku kungayambitse kuwonongeka kwa maselo ndi maselo, poika maselo pansi pa kupsinjika kwa okosijeni komwe sangathe kuwononga thupi kapena kuwonongeka kwa thupi.
Kutupa kungayambitse mwachindunji ma jini kumene maselo a maselo amtundu wa maselo amatha kusintha-zomwe zimachitika nthawi zambiri mu selo imfa kapena chitukuko cha kusintha kwa khansa. M'kupita kwanthawi, maselo okhudzidwa amasiya kugawikana, ndipo thupi lonse lathunthu.
Chiwerewere chisanafike chikhoza kuyambitsa matenda ena, komanso makhalidwe monga kusuta ndi kunenepa kwambiri, kapena zinthu zachilengedwe monga zowononga kapena zowonongeka.
Senescence Premature ndi HIV Infection
Pamene anthu omwe ali ndi HIV angathe kuyembekezera kuti azikhala ndi moyo wapafupi, atapatsidwa nthawi yeniyeni ya ART, makamaka pakuika matenda ambiri omwe alibe kachilombo ka HIV omwe angathe kubwezera zambiri. Ndipotu, m'mayiko ambiri otukuka, matenda opangidwa ndi chitetezo cha mthupi-chotchedwa matenda opatsirana-salinso opha anthu omwe ali ndi HIV.
M'malo mwake, khansa zosagwirizana ndi Edzi masiku ano ndizo zimayambitsa imfa ya anthu omwe ali ndi kachilombo ka HIV ku North America ndi Europe, omwe amapezeka zaka khumi ndi ziwiri zoposa khumi ndi chimodzi kusiyana ndi anzawo omwe alibe kachilomboka. Mofananamo, kuwonongeka kwa matenda okhudzana ndi ukalamba kumawonetsedwa kwa anthu omwe ali ndi kachilombo ka HIV pa zaka makumi asanu ndi zisanu ndi zisanu ndi zinayi (46), pomwe zaka zapakati zapakati zapakati pa mtima zimakhala zaka 49 mpaka zaka zisanu ndi ziwiri zisanachitike kuposa amuna ndi akazi omwe sagwiriridwa.
Ngakhale pamene kachilombo ka HIV kakuyendetsedwa bwino ndi njira yothetsera ma ARV (antiretroviral therapy) , anthu omwe ali ndi kachilombo ka HIV amayamba kudwala matenda okalamba, ngakhale kuti ndi ochepa kwambiri.
Odwala omwe ali ndi matenda a ART oyambirira komanso CD4 nadir ambiri amaoneka kuti ali ndi vuto lochepa la kutupa kwachilendo kusiyana ndi omwe amayamba mankhwala mochedwa, pamene odwala omwe ali ndi ma ARV amalembedwa ngati osatetezedwa ndi zovuta zokhudzana ndi msinkhu kuposa anthu omwe sagwidwa kapena osagwira ntchito kuti akwaniritse matendawa.
Choncho, matenda opatsirana msanga ndi chithandizo chachikulu ndizofunika kuchepetsa ukalamba msanga womwe umatchulidwa mwa anthu omwe ali ndi HIV nthawi yaitali.
Zotsatira:
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