Kufunika Kwambiri Kugwiritsa Ntchito Mankhwala
Stribild (yomwe imadziwikanso kuti ndi quad piritsi) ndi piritsi imodzi, mankhwala osakaniza mankhwala omwe ali ndi mankhwala omwe ali ndi ma antiretroviral anayi omwe amagwiritsidwa ntchito pochiza HIV:
- tenofovir , nucleotide reverse transcriptase inhibitor
- emtricitabine, kachiwiri kachilombo ka nucleotide reverse transcriptase inhibitor
- elvitegravir , integrase inhibitor
- chowombera , kachilombo ka HIV
Stribild inavomerezedwa ndi US Food and Drug Administration (FDA) mu August 2012 kuti agwiritsidwe ntchito kwa akulu akulu 18 kapena kuposa omwe akuyambitsa ma ARV nthawi yoyamba, kapena awo omwe ali ndi kachilombo ka HIV omwe ataya zowonongeka (zosadziwika).
Kuwongolera ndi kuchitapo kanthu kwa Stribild kunayesedwa pa odwala akuluakulu omwe kale anali osapitizidwa kale m'zipatala ziwiri zam'chipatala, zomwe zinatsimikizira kuti Stribild inali yothandiza komanso yolekerera monga Atripla , mankhwala ena omwe anali ndi tenofovir, emtricitabine, ndi efavirenz .
Mu 2016, machitidwe atsopano a mankhwala omwe amatchedwa Genvoya adapatsidwa chilolezo ndi FDA, m'malo mwa tenofovir ndi mankhwala atsopano omwe amatchedwa tenofovir alafenamide (TAF), omwe amadziwika kuti ali ndi zotsatira zochepa ndi mankhwala ochepetsa mankhwala.
Kupanga
Chithunzi chojambulidwa ndi piritsi yobiriwira, yofiira, yomwe imakhala ndi 150mg ya elvitegravir, 150mg ya cobicistat, 200mg ya emtricitabine ndi 300mg ya tenofovir. Ili ndi "GSI" kumbali imodzi ndipo ili ndi "1" yomwe ili pamtunda pa ina.
Mlingo
Phale limodzi tsiku ndi tsiku amatengedwa ndi chakudya. Seweroli sayenera kutengedwa ndi mankhwala ena opatsirana pogonana omwe amagwiritsidwa ntchito pochiza HIV.
Zotsatira Zotsatira
Zotsatira zochepa za mankhwala zakhala zikudziwika kwa odwala omwe akugwiritsa ntchito Stribild. Zovuta zowonongeka kwambiri, zomwe zinalembedwa mwa odwala 7% kapena kuposa, zinali:
- Nausea
- Kutsekula m'mimba
- Mutu
- Maloto osadziwika
Kuyanjana kwa Mankhwala kapena Kusagwirizana
Seweroli sayenera kutengedwa ndi mankhwala awa kapena mankhwala owonjezera:
- Mankhwala oletsa anti-migraine: Cafergot, Migergot, Ergostat, Ergotamine ya Medihaler, Wigraine, Wigrettes, Ergotrate, Methergine, DHE 45
- Mankhwala otsutsa-psychotic: Orap
- Cholesterol-kuchepetsa mankhwala a statin: Zocor, Simcor, Vytorin, Mevacor, Advicor, Altoprev, Mevacor
- Mankhwala a Hepatitis B: Hepsera, Preveon
- Prokinetic agents: Propulsid, Propulsid Quicksolv
- Mankhwala a prostatu: Uroxatral
- Mankhwala osokoneza bongo: Revatio
- Mankhwala opatsirana pogwiritsa ntchito mankhwala a Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Zochitika: Kunena, Halcion
- Wotchedwa St. John's Wort
Mfundo
Stribild ingakhale yovuta kwa anthu omwe ali ndi mbiri ya mavuto a impso. Chonde dalitsani dokotala kuti muli ndi nkhani zotere musanatenge Stribild. Ntchito ya impso iyenera kuyesedwa kawirikawiri kwa odwala pa Stribild. Pewani kuchipatala kwa odwala omwe ali ndi chilolezo cha creatinine pansi pa 50mL / mphindi. Mankhwala a Nephrotoxic sayenera kulamulidwa ndi Stribild.
Zida ziwiri zomwe zimagwira ntchito ku Stribild (tenofovir, emtricitabine) zimathandizanso kudwala matenda a hepatitis B (HBV) . Ngati muli ndi HBV ndikusiya kutenga Stribild, muyenera kufufuza mavitamini a chiwindi kwa miyezi ingapo pamene kuima kungachititse kuti HBV ifike.
Monga momwe ziliri ndi mzere woyamba wothandizira ma antiretroviral, ma NRTI mu Stribild akugwirizanitsidwa ndi chiopsezo chochepa cha lactic acidosis, komanso mavuto a chiwindi.
Ngati muli ndi mpweya wochepa; kunyoza ndi kusanza; kumva ululu kapena zosayembekezereka m'mimba; chilema ndi kutopa; kufooka m'manja ndi miyendo; kapena chikasu cha khungu ndi / kapena maso, itanani dokotala mwamsanga. Lactic acidosis, makamaka, ikhoza kupha ngati sichikutsatiridwa.
Zotsatira:
US Food and Drug Administration. "FDA imavomereza mapiritsi atsopano ogwiritsira ntchito kachilombo ka HIV kwa odwala ena." Silver Spring, Maryland; ndondomeko yotulutsidwa pa August 27, 2012.
Wohl, D .; Cohen, C ;; Gallant, J .; et al. "Elvitegravir / cobicistat / emtricitabine / tenofovir DF (STB) imakhala yothandiza kwambiri ndipo imasiyanitsa chitetezo cha nthawi yaitali ndi kulekerera ndi efavirenz / emtricitabine / tenofovir DF (ATR) pamasabata 144 omwe akudwala omwe alibe HIV." Msonkhano wa 53 wa Interscience on Antitimicrobial Agents ndi Chemotherapy (ICAAC). Denver, Colorado, September 11, 1013; zowonongeka H-672a.
Shalit, P .; Gallant, J .; Mitsulo, A .; et al. "Kuleza mtima kwa nthawi yaitali kwa elvitegravir / cobicistat / emtricitabine / tenofovir DF poyerekeza ndi efavirenz / emtricitabine / tenofovir DF kapena ritonavir-adathandizidwa atazanavir plus emtricitabine / tenofovir DF m'magawo omwe alibe HIV. Msonkhano wa 53 wa Interscience on Antitimicrobial Agents ndi Chemotherapy (ICAAC). Denver, Colorado; September 11, 2013; zowonongeka H-671.