Technivie (ombitasvir + paritaprevir + ritonavir) ndi mankhwala osakaniza omwe amagwiritsidwa ntchito pochiza matenda opatsirana a hepatitis C (HCV) . Atumiki atatu omwe amaphatikizapo Technivie amathandizidwanso mu mankhwala awiri a HCV, Viekira Pak .
Technivie inavomerezedwa pa July 24, 2015 ndi US Food and Drug Administration (FDA) kuti agwiritsidwe ntchito kwa anthu akuluakulu zaka 18 kapena kupitilira ndi matenda a HCV genotype 4 (GT4) popanda chiwindi .
Technivie ndi mankhwala oyamba omwe amachititsa odwala GT4 matenda aakulu a HCV, omwe ambiri amawaona kuti ndi ovuta kuchiza.
Technivie adanenedwa kuti anali ndi mankhwala ochiritsidwa a 100% omwe sanatengedwe (odwala mankhwala ndiive) m'ndende ya Phase IIb yomwe inachitikira kuyambira pa August 12, 2012 mpaka November 19, 2013.
Mlingo
Mapiritsi awiri (12.5mg ombitasvir, 75mg paritaprevir, 50mg ritonavir) amatengedwa tsiku lililonse ndi chakudya popanda kusowa kwa mafuta olemera kapena caloric. Mapiritsi a Technivie ndi ofiira, oblong ndi mafilimu ophimbidwa, ndi "AV1" omwe ali pambali imodzi.
Kulemba Malangizo
Technivie imayikidwa pa maphunziro a masabata 12 pamodzi ndi ribavirin (mankhwala omwe amachititsa kuti tizilombo toyambitsa matenda a RNA asakanike). Mlingo woyenera wa ribavirin umakhala wolemera, motere:
- Pansi pa 165 lbs (75kg): 1000mg tsiku ndi tsiku, ogawanika ndi kuperekedwa kawiri tsiku ndi tsiku ndi chakudya
- 165 lbs (75kg) ndi kupitirira: 1250mg tsiku ndi tsiku, ogawanika ndi kuperekedwa kawiri tsiku ndi tsiku ndi chakudya
Njira ya Technivie ya masabata 12 ingaganizidwe kuti ndi odwala omwe amalephera kupirira ribavirin.
Zotsatira Zogwirizana
Zotsatira zambiri zomwe zimakhudzana ndi kugwiritsidwa ntchito kwa Technivie (zomwe zimachitikira odwala oposa 7%) ndi:
- Kufooka kwa thupi
- Kutopa
- Nausea
- Kusagona
- Rash
Mankhwala a Contraindicated
Mankhwala otsatirawa sayenera kuthandizidwa pogwiritsa ntchito Technivie:
- Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- Antipsychotics: Orap
- Mankhwala opatsirana pogonana: Sustiva
- Cholesterol-kuchepetsa mankhwala a statin: Altoprev, Mevacor, Zocor
- Mankhwala osokonezeka a Erectile: Revatio
- Zotsatira za Ergot (zomwe zimagwiritsidwa ntchito pochizira mutu): DHE 45, Ergomar, Ergotrate, Hydergine, Migranal
- Mimba ya Estinyl isradiol: Estinyl, Apri, Reclipsen, Azurette, Kariva, Yaz, Yasmin, Ocella, Vestura, Beyaz, Safyral, Zovia, Demulen, Demulen 1/35, Kelnor 1/35, Ninda Ring, FaLessa, Luther , Seasonique, Aviane, Ortho Evra, Xulane, Lo Loestrin Fe, Necon 1/35, Minastrin 24 Fe, Loestrin 24 Fe, Ortho Tri-Cyclen, Sprintec, Ortho Tri-Cyclen Lo, Tri-Sprintec, Cryselle, Lo / Ovral, Ovral, Elinest
- Mankhwala opatsirana pogwiritsa ntchito mankhwala a Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Zochitika: Kunena, Halcion
- Wotchedwa St. John's Wort
Kusamvana ndi kulingalira
Technivie siyikulimbikitsidwa kwa odwala omwe ali ndi vuto lopweteka kwambiri (chiwerengero cha Child-Pugh B) ndipo amatsutsana ndi odwala omwe ali ndi vuto loipa kwambiri (chiwerengero cha Child-Pugh C).
Technivie ikutsutsana ndi ntchito kwa odwala omwe amadziwika kuti hypitensitivity kwa ritonavir (mwachitsanzo, omwe awona Stevens-Johnson Syndrome kapena poizoni epidermal necrolysis).
Ngakhale kuti Technivie yokha sichitsutsana ndi zomwe zimagwiritsidwa ntchito panthawi yoyembekezera, kuphatikizapo Technivie ndi ribavirin sikuyenera kugwiritsidwa ntchito ngakhale kwa amayi omwe ali ndi pakati kapena abambo omwe ali ndi pakati. Ponena za kuyamwitsa, panalibe zochitika za chidziwitso chodziwika bwino cha fetus mu maphunziro a nyama; Kufunsidwa kwa akatswiri kumalimbikitsidwa kuti tikambirane zomwe zingathandize komanso zotsatira zovuta za kuyamwitsa pamene tikugwiritsa ntchito Technivie.
Chitsime:
US Food and Drug Administration (FDA). "FDA imavomereza Technivie kuchiza matenda aakulu a chiwindi cha hepatitis C 4." Silver Spring, Maryland; ndondomeko yofalitsa yomwe inatulutsidwa pa July 24, 2015.
Hézode, C .; Asselah, T .; Reddy, R .; et al. "Ombitasvir plus paritaprevir plus ritonavir ndi kapena opanda ribavirin odwala omwe ali ndi matenda odwala matenda a hepatitis C (PEARL-I). Lancet. June 20, 2015; 384 (9986): 2502-2509.