Kulemba
Viekira Pak ndi mankhwala ogwiritsira ntchito mankhwala omwe amagwiritsidwa ntchito pochiza matenda aakulu a chiwindi (hepatitis C (HCV) . Phukusili mumakhala mankhwala amodzi omwe amagwiritsidwa ntchito pogwiritsa ntchito mankhwala a Technivie (ombitasvir + paritaprevir + ritonavir) pamodzi ndi mankhwala a dasabuvir.
Mankhwala osokoneza bongo ombitasvir, paritaprevir ndi dasabuvir amachititsa kuti mankhwalawa asatetezedwe (DAAs) omwe amalepheretsa kubwezeretsa kachilomboka.
Mankhwala amtundu wa ritonavir , omwe amagwiritsidwa ntchito mobwerezabwereza mu HIV , amaphatikizidwa kuti apititse patsogolo mankhwalawa a paritaprevir.
Viekira Pak nthawi zambiri, koma nthawi zonse, amathandizidwa ndi ribavirin ndipo safunikira kutengedwa ndi pegylated interferon (peg-interferon).
Viekira Pak inavomerezedwa mu December 19, 2014 ndi US Food and Drug Administration (FDA) kuti agwiritsidwe ntchito kwa anthu akuluakulu zaka 18 kapena kupitilira ndi matenda a HCV 1, kuphatikizapo omwe ali ndi matenda a chiwindi (omwe chiwindi chimagwirabe ntchito) komanso zizindikiro za chiwindi. Kwa odwala omwe ali ndi chifuwa chachikulu, Viekira Pak sali woyenera.
Viekira Pak imakhala ndi mankhwala ochulukirapo oposa 95% kapena kuposa, ndi 2% odwala okha omwe amasiya mankhwala chifukwa chosasalana. Ndibwino kugwiritsa ntchito odwala omwe ali ndi kachirombo ka HIV / HCV .
Mlingo
Mapiritsi awiri a mapiritsi opangidwa ndi ombitasvir + paritaprevir + ritonavir (25mg / 150mg / 100mg) amatenga tsiku limodzi m'mawa ndi chakudya, kuphatikizapo tebulo limodzi la dasabuvir loperekedwa kawiri tsiku lililonse m'mawa ndi madzulo ndi chakudya.
Ma mapiritsi amabwera mowonjezereka m'mayeso a tsiku ndi tsiku, ali ndi malangizo omwe akuphatikizidwa pabokosi lililonse. Pulogalamuyi imakhala yofiira, yophimbidwa ndi mafilimu komanso yodetsedwa ndi "AV1", pomwe piritsi ya dasabuvir ili ndi beige, yokutidwa ndi filimu ndipo imakhala ndi "AV2".
Kulemba Malangizo
Viekira Pak imapatsidwa maphunziro apakati pa masabata 12 mpaka 24, malinga ndi zotsatirazi:
- Genotype 1a popanda cirrhosis: Viekira Pak ndi ribavirin kwa masabata 12
- Genotype 1a ndi chiwindi: Viekira Pak ndi ribavirin kwa masabata 24
- Genotype 1b popanda cirrhosis: Viekira Pak yekha kwa milungu 12
- Genotype 1b popanda cirrhosis: Viekira Pak ndi ribavirin kwa masabata 24
Kwa odwala matenda a chiwindi, Viekira Pak akhoza kutengedwa ndi ribavirin kwa masabata 24 okha ngati ntchito ya hepatic (chiwindi) ndi yachibadwa komanso fibrosis (scarring) ndi yaing'ono.
Zotsatira Zogwirizana
Zotsatira zambiri zomwe zimakhudzana ndi kugwiritsidwa ntchito kwa Viekira Pak (zomwe zimachitikira odwala 10%) ndi:
- Kutopa
- Nausea
- Khungu lachitsulo
- Zochita za khungu
- Kusagona
- Kufooka ndi kutopa
Kuyanjana kwa Mankhwala
Zotsatirazi ziyeneranso kupeĊµa pamene mukugwiritsa ntchito Viekira Pak:
- Anticonvulsants: carbamazepine, phenytoin, phenobarbital
- Antihyperlipidemics (yogwiritsira ntchito kuchepetsa m'magazi m'magazi): gemfibrozil
- Mankhwala otsutsana ndi arrhythmia: pimozide
- Mankhwala othandiza kuchepetsa mafuta m'thupi: lovastatin, simvastatin
- Mankhwala osokonezeka a Erectile: Viagra (sildenafil)
- Mankhwala opangira Ergot (omwe amagwiritsidwa ntchito pochizira mutu ndi migraines): ergotamine, dihydroergotamine, ergonovine, methylergonovine
- Ethinyl estradiol (mawonekedwe opangidwa ndi anthu a estrogen)
- Mankhwala a HIV : Sustiva (efavirenz) , Atripla (efavirenz + tenofovir + emtricitabine)
- Mankhwala osakaniza: alfuzosin
- Mankhwala opatsirana pogwiritsa ntchito mankhwala a Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Zotsatira: triazolam, midazolam yomlomo
Kusamvana ndi kulingalira
Kwa odwala omwe ali ndi vuto lopweteka kwambiri, Viekira Pak sali woyenera. Viekira Pak imavomerezedwa kuti igwiritsidwe ntchito kwa odwala omwe ali ndi vuto lalikulu.
Viekira Pak imagwirizananso ndi ntchito yogwiritsira ntchito odwala ndi kudzidzidzidzidwa kwa ritonavir (kuphatikizapo Stevens-Johnson Syndrome, omwe angawopsyeze moyo wawo wonse).
Viekira Pak imavomerezedwa kuti igwiritsidwe ntchito kwa amayi apakati pamene agwiritsidwa ntchito ndi ribavirin.
Ndikoyenera kuti amayi onse omwe ali ndi zaka zakubadwa ayenera kuyang'aniridwa mwezi uliwonse kuti akhale ndi pakati pa nthawi ya mankhwala. Tiyeneranso kuti wodwalayo ndi mwamuna wake apatsedwe njira zosachepera ziwiri zosamalidwa, komanso kuti azigwiritsidwa ntchito pakapita nthawi ndi miyezi isanu ndi umodzi.
Chitsime:
US Food and Drug Administration (FDA). "FDA imavomereza Viekira Pak kuti ikhale ndi matenda a hepatitis C." Silver Spring, Maryland; ndondomeko yomasulira yomwe inatulutsidwa pa December 19, 2014.